FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 335:483-489 August 15, 1996 Number 7 Next

Abstract PDF Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article PubMed Citation

ABSTRACT

Background Laparoscopically assisted vaginal hysterectomy has been promoted as a substitute for both abdominal and vaginal hysterectomy, with claimed benefits of lower costs, shorter hospital stays, and quicker postoperative recovery.

Methods Using computerized hospital-discharge data for 1988–1994 from 180 hospitals in Ohio, we analyzed rates of abdominal, vaginal, and laparoscopically assisted vaginal hysterectomy and their association with characteristics of patients, complications, in-hospital mortality, and hospital charges.

Results The annual age-adjusted rate of hysterectomy fell 10 percent, from 4.53 per 1000 female state residents in 1988 to 4.07 per 1000 in 1994 (P<0.001). In 1988, 1.1 percent of all hysterectomies were performed by the laparoscopically assisted vaginal technique; this proportion increased to 9.2 percent in 1993 and declined to 7.5 percent in 1994. For gynecologic conditions other than cancer or pregnancy, women undergoing laparoscopically assisted vaginal hysterectomy as compared with one of the other techniques were more likely to have commercial insurance and to have their surgery at an urban hospital for diagnoses related to pain, endometriosis, or pelvic inflammatory disease. With abdominal and laparoscopically assisted vaginal hysterectomy, the complication rates were similar and were higher than those with vaginal hysterectomy. In-hospital mortality was similar for vaginal and laparoscopically assisted vaginal hysterectomy and was lower than for abdominal hysterectomy. Median hospital charges were $8,108 for laparoscopically assisted vaginal hysterectomy, $5,723 for abdominal hysterectomy, and $5,049 for vaginal hysterectomy.

Conclusions The rate of hysterectomy in Ohio decreased from 1988 to 1994, as laparoscopically assisted vaginal hysterectomy became more common. Laparoscopically assisted vaginal hysterectomy was associated with higher hospital charges than the other techniques.

We studied the use of abdominal, vaginal, and laparoscopically assisted vaginal hysterectomy in Ohio from 1988 to 1994. We sought to determine whether the introduction of the laparoscopically assisted vaginal technique was associated with changes in the rate of hysterectomy and whether differences in the characteristics of patients, complications, in-hospital mortality, and hospital charges were associated with the various procedures.

Methods

Sources of Data

The study data were obtained from a computerized data base on inpatients maintained by the Ohio Hospital Association that contains information on 96 percent of hospital discharges in the state. Psychiatric and specialty hospitals are excluded from the data base, and 16 hospitals do not participate, leaving 180 nonfederal, short-stay hospitals.

The hospital-discharge data from January 1, 1988, through December 31, 1994, include information on the age, race, and county and state of residence of the patients; health-insurance status; length of hospital stay; vital status at discharge; diagnosis-related group, with information on complications; and hospital charges (not including physicians' fees). For more than 99 percent of patients, the data were complete for all variables except race; data on race were missing for 27 percent. The association estimates that the error rate in the coding is 1 percent. Codes from the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) were obtained for up to five procedures and five diagnoses per discharge. Hospitals were grouped according to the number of discharges per year and were classified as small (with fewer than 9000 discharges; 124 hospitals), medium-sized (9000 to 14,999 discharges; 29 hospitals), or large (15,000 or more discharges; 27 hospitals). They were also grouped according to location, as either urban (located in one of six metropolitan counties; 69 hospitals) or rural (located in any other county; 111 hospitals). Health insurance was classified as commercial (including Blue Cross–Blue Shield and other private insurers), provided by the government (including Medicare, Medicaid, and workers' compensation), or other (including health maintenance organizations and self-pay plans). Hospital-specific data were not available.

Identification of Cases

ICD-9-CM procedure codes were used to identify hospitalizations during which hysterectomy was performed. Abdominal hysterectomy was identified by codes 68.4 (total hysterectomy, 132,761 cases), 68.3 (subtotal hysterectomy, 283 cases), 68.6 (radical abdominal hysterectomy, 269 cases), 68.8 (pelvic evisceration, 60 cases) and 68.9 (unspecified hysterectomy, 128 cases). Vaginal hysterectomy was identified by codes 68.5 (37,821 cases) and 68.7 (radical hysterectomy, 6 cases). Since there was no unique code for laparoscopically assisted vaginal hysterectomy, that procedure was identified by the appearance of any hysterectomy code together with code 54.21, for laparoscopy (7979 cases).

Statistical Analysis

All cases with a diagnostic code for hysterectomy were analyzed initially, and then, to limit the analysis to benign gynecologic conditions, the data were reanalyzed after the exclusion of cases with codes related to genitourinary cancer (codes 179 through 189) or pregnancy (codes 630 through 676).

Crude and age-adjusted rates of hysterectomy were determined for each calendar year. The denominators for the rates were derived from the census figures for Ohio; the size of the population in 1988, 1989, 1991, 1992, and 1993 was estimated⁷; the data for 1990 were taken from the census⁸; and the 1994 data were projections.⁹ Age-adjusted rates were calculated by direct adjustment for age, with the 1990 census population selected as the standard population.¹⁰ Without accurate information about the percentage of women of each age in each year who had already undergone hysterectomy, it was not possible to calculate rates specifically applicable to women at risk for the operation. If women who have already undergone hysterectomy are not excluded from the denominator of women at risk for the procedure, the use of the uncorrected rates may underestimate the true rates of hysterectomy by up to 25 percent.^11,12

The diagnostic codes were used to determine what complications had occurred, and the complications were grouped according to organ system. In-hospital mortality was defined as death during the hospitalization in which hysterectomy was performed. Data on the length of hospital stays and on charges were aggregated and expressed as medians with interquartile ranges (from the 25th percentile to the 75th percentile), since these are less sensitive to the effect of extreme values than means and standard deviations. Values were compared by nonparametric Kruskal–Wallis tests.¹³ Hospital charges for the years 1988 through 1993 were adjusted for inflation to the equivalent of 1994 dollars; adjusted charges for each year were then aggregated to calculate medians and ranges. The univariate association of each factor with surgical technique (in pairwise comparisons) and with in-hospital mortality was evaluated by the chi-square test or Fisher's exact test for categorical variables and by Student's t-test for continuous variables. Changes over time were tested by the Armitage test for linear trend.¹⁴ All tests were two-sided; P values of 0.05 or less were considered to indicate statistical significance.

The logistic-regression analyses used a forward stepwise procedure, with a P value of 0.15 required for a variable to be included in the model and a P value of 0.05 for it to remain. Adjusted odds ratios are shown for all characteristics in the model that were statistically significant.¹⁵ As stated above, all the data were analyzed initially, and the analysis was then repeated after the exclusion of cases related to cancer or pregnancy. Because data on race were missing in 27 percent of cases, the analysis was performed with and without that variable; the odds ratios did not differ significantly with either method. Hosmer–Lemeshow goodness-of-fit tests were used with each logistic-regression model to test how the model fit the data.¹⁶ Discrepancies between the observed and the expected data were summarized by Pearson chi-square statistics. A nonsignificant result on the Hosmer–Lemeshow goodness-of-fit test indicates a good fit of the model. In addition, we used the C-statistic, which measures the predictive power of the model; the higher the value of the statistic (range, 0 to 1), the greater the predictive value.

Results

The data base included 179,307 hysterectomies, of which 133,501 were abdominal (74.5 percent), 37,827 were vaginal (21.1 percent), and 7979 were vaginal with laparoscopic assistance (4.4 percent). Table 1 shows the age-adjusted rates at which the three techniques of hysterectomy were used in each calendar year. Overall, the rate of hysterectomy decreased 10 percent between 1988 and 1994 (P<0.001). In 1988, 1.1 percent of all hysterectomies were performed by the laparoscopically assisted vaginal technique; this proportion increased to 9.2 percent in 1993, then dropped to 7.5 percent in 1994. Vaginal hysterectomy was performed at a similar rate throughout the study period, but the proportion of such hysterectomies increased from 20.3 to 24.3 percent (P<0.001). The proportion of abdominal hysterectomies decreased from 78.6 percent in 1988 to 68.0 percent in 1994 (P<0.001).

View this table: [in this window] [in a new window]   Table 1. Age-Adjusted Rates of Hysterectomy in Ohio, 1988 through 1994, According to the Surgical Technique Used.

 
The characteristics of the patients are shown in Table 2. From 1988 to 1994, the median hospital stay decreased from 5.0 days to 2.0 days with laparoscopically assisted vaginal hysterectomy, from 5.0 to 3.0 days with abdominal hysterectomy, and from 4.0 to 2.0 days with vaginal hysterectomy.

View this table: [in this window] [in a new window]   Table 2. Characteristics of 179,307 Patients Who Underwent Hysterectomy from 1988 through 1994, According to the Surgical Technique Used.

 
The characteristics of the patients with benign gynecologic conditions who underwent abdominal and laparoscopically assisted vaginal hysterectomy are compared by multiple logistic-regression analysis in Table 3, and the characteristics of those who underwent vaginal and laparoscopically assisted vaginal hysterectomy are compared in Table 4. In both analyses, the women who underwent laparoscopically assisted vaginal hysterectomy were more likely to have commercial health insurance and to have their surgery at an urban hospital for a diagnosis related to pain (dysmenorrhea, pelvic pain, or unspecified abdominal pain), endometriosis, or pelvic inflammatory disease. Women who underwent laparoscopically assisted vaginal hysterectomy or vaginal hysterectomy were more likely than those undergoing abdominal hysterectomy to be white (85.6 percent, 84.9 percent, and 77.5 percent, respectively). Unilateral or bilateral oophorectomy or salpingo-oophorectomy was performed in 66.7 percent, 18.4 percent, and 75.3 percent of laparoscopically assisted vaginal, vaginal, and abdominal hysterectomies, respectively. There was a strong interaction between the year of the study and the type of insurance. A higher proportion of women with commercial insurance as compared with government or another type of insurance underwent laparoscopically assisted vaginal hysterectomy in 1994 (9.4 percent vs. 5.5 percent) than did so in 1988, when the proportions were more similar (1.2 percent vs. 1.3 percent).

View this table: [in this window] [in a new window]   Table 3. Characteristics of the Subgroup of 90,880 Patients Who Underwent Abdominal Hysterectomy or Laparoscopically Assisted Vaginal Hysterectomy for Benign Gynecologic Conditions, 1988 through 1994, and Odds Ratios for Laparoscopically Assisted Surgery.

 

View this table: [in this window] [in a new window]   Table 4. Characteristics of the Subgroup of 33,653 Patients Who Underwent Vaginal Hysterectomy or Laparoscopically Assisted Vaginal Hysterectomy for Benign Gynecologic Conditions, 1988 through 1994, and Odds Ratios for Laparoscopically Assisted Surgery.

 
The percentage of procedures to treat benign gynecologic conditions during which there were complications was similar for abdominal hysterectomy and laparoscopically assisted vaginal hysterectomy (9.1 percent and 8.8 percent) and lower for vaginal hysterectomy (7.8 percent) (Table 5). Complications related to hemorrhage (intraoperative and postoperative) or the accidental laceration of blood vessels, nerves, or organs were most common with laparoscopically assisted vaginal hysterectomy. There were no clear trends over the study period in the rate of complications with laparoscopically assisted vaginal hysterectomy. Urinary complications, such as oliguria, anuria, and acute renal failure, were more common with vaginal hysterectomy. Abdominal hysterectomy was associated with a higher rate of gastrointestinal complications, such as intestinal obstruction.

View this table: [in this window] [in a new window]   Table 5. Complications Associated with Hysterectomies for Gynecologic Conditions Other Than Pregnancy or Cancer, According to the Surgical Technique Used.

 
Of the 179,307 patients, 274 died, for an overall in-hospital mortality rate of 15.3 per 10,000 procedures. Multiple logistic-regression analysis showed that age, insurance, and technique of hysterectomy were significant factors (P = 0.07 by the Hosmer–Lemeshow goodness-of-fit test; C-statistic = 0.85). For all patients, the adjusted odds ratio for death after vaginal or laparoscopically assisted vaginal hysterectomy as compared with abdominal hysterectomy was 0.23 (95 percent confidence interval, 0.15 to 0.36). Of the 17,038 patients with cancer or pregnancy, 152 died (55 percent of all deaths), for an in-hospital mortality rate of 89.2 per 10,000 procedures. The in-hospital mortality rate for women with benign gynecologic conditions was 7.5 per 10,000 procedures (8.8, 4.3, and 3.8 per 10,000 procedures for abdominal, vaginal, and laparoscopically assisted vaginal hysterectomies, respectively). Among these women, multiple logistic-regression analysis revealed that after adjustment for age and insurance status, the odds ratio for death after vaginal or laparoscopically assisted vaginal hysterectomy as compared with abdominal hysterectomy was 0.19 (95 percent confidence interval, 0.12 to 0.32; P=0.67 by the Hosmer–Lemeshow goodness-of-fit test; C-statistic = 0.83). Women with Medicare or Medicaid insurance were more likely to die than women with private or other insurance (odds ratio after adjustment for age and technique of hysterectomy, 2.9; 95 percent confidence interval, 1.6 to 5.4).

The median hospital charges for the three procedures differed significantly when all the cases were included in the analysis. The median charge for laparoscopically assisted vaginal hysterectomy was $8,108 (interquartile range, $6,074 to $10,404), as compared with $5,723 for abdominal hysterectomy (interquartile range, $4,245 to $7,797) and $5,049 for vaginal hysterectomy (interquartile range, $3,675 to $6,798).

Discussion

In contrast to the increased rate of cholecystectomy associated with the introduction of laparoscopic cholecystectomy,^5,6 the rate of hysterectomy in Ohio decreased between 1988 and 1994 as laparoscopically assisted vaginal hysterectomy became more common. Our findings are consistent with other reports of a nationwide decrease in the rate of hysterectomy since 1975.^17,18 Although the rate of vaginal hysterectomy remained virtually unchanged, the rate of abdominal hysterectomy decreased more than the rate of laparoscopically assisted vaginal hysterectomy increased. Despite initial claims of a savings in cost with laparoscopically assisted vaginal hysterectomy,² we found, as have others,^3,4,19,20,21 that this technique was associated with higher charges than the other two techniques.

Although factors such as the type of health insurance, the location of the hospital, and the presence of a diagnosis related to pain, endometriosis, or pelvic inflammatory disease were significantly associated with the technique of hysterectomy chosen, other considerations that we could not study are also important. For example, the practice style and surgical experience of the physician have been identified as important variables influencing the decision to perform hysterectomy by a specific technique.^22,23

Several limitations of our study should be acknowledged. The validity of the data base depends on complete and accurate reporting by the participating hospitals. It was impossible to verify the accuracy of the data independently. There was no unique ICD-9-CM code for laparoscopically assisted vaginal hysterectomy, and there may have been misclassification for that reason. The combination of the procedure codes for laparoscopy and hysterectomy was used as a proxy for laparoscopically assisted vaginal hysterectomy, but we had no way of determining what portion of the procedure was accomplished laparoscopically.

The data base includes only procedures performed on an inpatient basis. There is no centralized mechanism for reporting outpatient hysterectomy in Ohio, although the feasibility of performing vaginal hysterectomy for selected patients as outpatients under tightly controlled conditions has been reported.^4,24 Some such outpatients may have required admission to the hospital because of complications. These complications and the associated charges would tend to be overestimated by the lack of access to data on uncomplicated outpatient hysterectomies (which, presumably, would have been vaginal or laparoscopically assisted vaginal procedures, rather than abdominal ones). Given the small proportion of hysterectomies performed on an outpatient basis, however, their effect, if any, was probably small.

Our analysis probably underestimates the complications and mortality associated with hysterectomy. Data were not available on hospital readmissions, delayed postoperative complications, and deaths, except for deaths that occurred during the hospitalization for hysterectomy. The mortality rate of patients undergoing hysterectomy has been reported as 10.8 to 12 per 10,000 procedures, and the rate of rehospitalization after hysterectomy for benign gynecologic conditions as 2.3 percent.^25,26 Although we found that the mortality rates associated with vaginal and laparoscopically assisted vaginal hysterectomy were similar and that the rate associated with abdominal hysterectomy was lower, the rate of complications associated with laparoscopically assisted vaginal hysterectomy was similar to that associated with abdominal hysterectomy and higher than that associated with vaginal hysterectomy. Patients are selected for these procedures in relation to the risk of complications; abdominal hysterectomy, for example, is traditionally performed when surgery is likely to be difficult. The relative risk of complications associated with the various techniques requires further study.

The charges we studied represent overall hospital charges per admission. It was impossible to determine what specific elements accounted for the higher charges associated with laparoscopically assisted vaginal hysterectomy. Other studies have shown that although hospital stays are shorter, these higher charges are due to longer operating times and to the use of expensive disposable instruments.^3,4,19,20,21 Hospital stays have decreased dramatically for all types of admissions. However, in the case of surgical admissions, shorter stays have less effect on the total cost, since the costs for the first day (the day of surgery) are high in relation to the overall costs. Savings from shorter stays may be offset by increased intraoperative charges. Therefore, reducing intraoperative costs is particularly important for decreasing overall costs.

The distinction between costs and charges is crucial. Costs denote the cost to the provider of producing the care. There is considerable merit in reporting the actual costs of providing care rather than the charges for the care, but data on cost were not available to us. Hospital charges reflect the amounts billed and do not closely correlate with costs; charges do not include physicians' fees and are not necessarily the amounts reimbursed by third-party payers. To the hospital, charges are less important than costs, but charges are important to the insurer, since they are the amounts billed, and to the patient, who may be responsible for copayments based on those amounts. In addition, data on charges are useful in a relative sense rather than an absolute one.

We also could not assess the indirect costs of hysterectomy, such as the time needed to recover and the patient's time away from work. The return to full activity depends on many factors other than the procedure itself, factors that include personal motivation and the amount of time a patient is permitted by her insurance to remain on disability. The higher hospital charges associated with laparoscopically assisted vaginal hysterectomy may be offset if recovery is faster. It is not known whether this is so.

Supported by a grant from Ethicon Endosurgery, Cincinnati.

Source Information

From the Departments of Gynecology and Obstetrics (A.M.W.) and Biostatistics and Epidemiology (J.-C.L.), Cleveland Clinic Foundation, Cleveland.

Address reprint requests to Dr. Weber at the Cleveland Clinic Foundation, 9500 Euclid Ave. A81, Cleveland, OH 44195.

References

1. Padial JG, Sotolongo J, Casey MJ, Johnson C, Osborne NG. Laparoscopy-assisted vaginal hysterectomy: report of seventy-five consecutive cases. J Gynecol Surg 1992;8:81-85. [CrossRef][Medline]
2. Liu CY. Laparoscopic hysterectomy: a review of 72 cases. J Reprod Med 1992;37:351-354. [Medline]
3. Nezhat C, Bess O, Admon D, Nezhat CH, Nezhat F. Hospital cost comparison between abdominal, vaginal, and laparoscopy-assisted vaginal hysterectomies. Obstet Gynecol 1994;83:713-716. [Medline]
4. Summit RL Jr, Stovall TG, Lipscomb GH, Ling FW. Randomized comparison of laparoscopy-assisted vaginal hysterectomy with standard vaginal hysterectomy in an outpatient setting. Obstet Gynecol 1992;80:895-901. [Medline]
5. Steiner CA, Bass EB, Talamini MA, Pitt HA, Steinberg EP. Surgical rates and operative mortality for open and laparoscopic cholecystectomy in Maryland. N Engl J Med 1994;330:403-408. [Free Full Text]
6. Escarce JJ, Chen W, Schwartz JS. Falling cholecystectomy thresholds since the introduction of laparoscopic cholecystectomy. JAMA 1995;273:1581-1585. [Free Full Text]
7. Bureau of the Census, Byerly ER. State population estimates by age and sex: 1980 to 1992. Current population reports: population estimates and projections. Series P-25. No. 1106. Washington, D.C.: Government Printing Office, 1990.
8. Bureau of the Census. 1990 Census of population: general population characteristics: Ohio. Washington, D.C.: Government Printing Office, 1990.
9. Bureau of the Census, Campbell PR. Population projections for states, by age, sex, race, and Hispanic origin: 1993 to 2020. Current population reports. Series P-25. No. 1111. Washington, D.C.: Government Printing Office, 1994.
10. Lilienfeld AM, Lilienfeld DE, eds. Foundations of epidemiology. 2nd ed. New York: Oxford University Press, 1980.
11. Pokras R, Hufnagel VG. Hysterectomy in the United States, 1965-84. Am J Public Health 1988;78:852-853. [Free Full Text]
12. Luoto R, Kaprio J, Keskimaki I, Pohjanlahti J-P, Rutanen E-M. Incidence, causes and surgical methods for hysterectomy in Finland, 1987-1989. Int J Epidemiol 1994;23:348-358. [Free Full Text]
13. Conover WJ. Practical nonparametric statistics. 2nd ed. New York: John Wiley, 1980.
14. Armitage P. Tests for linear trends in proportions and frequencies. Biometrics 1955;11:375-386. [CrossRef]
15. Agresti A. Analysis of ordinal categorical data. New York: John Wiley, 1984.
16. Hosmer DW, Lemeshow S. Goodness of fit tests for the multiple logistic regression model. Commun Stat Theory Methods 1980;A9:1043-69.
17. Dicker RC, Scally MJ, Greenspan JR, et al. Hysterectomy among women of reproductive age: trends in the United States, 1970-1978. JAMA 1982;248:323-327. [Free Full Text]
18. Wilcox LS, Koonin LM, Pokras R, Strauss LT, Xia Z, Peterson HB. Hysterectomy in the United States, 1988-1990. Obstet Gynecol 1994;83:549-555. [Medline]
19. Boike GM, Elfstrand EP, DelPriore G, Schumock D, Holley HS, Lurain JR. Laparoscopically assisted vaginal hysterectomy in a university hospital: report of 82 cases and comparison with abdominal and vaginal hysterectomy. Am J Obstet Gynecol 1993;168:1690-1701. [Medline]
20. Phipps JH, John M, Nayak S. Comparison of laparoscopically assisted vaginal hysterectomy and bilateral salpingo-oophorectomy with conventional abdominal hysterectomy and bilateral salpingo-oophorectomy. Br J Obstet Gynaecol 1993;100:698-700. [Medline]
21. Harris MB, Olive DL. Changing hysterectomy patterns after introduction of laparoscopically assisted vaginal hysterectomy. Am J Obstet Gynecol 1994;171:340-344. [Medline]
22. Kovac SR, Christie SJ, Bindbeutel GA. Abdominal versus vaginal hysterectomy: a statistical model for determining physician decision making and patient outcome. Med Decis Making 1991;11:19-28.
23. Dorsey JH, Steinberg EP, Holtz PM. Clinical indications for hysterectomy route: patient characteristics or physician preference? Am J Obstet Gynecol 1995;173:1452-1460. [CrossRef][Medline]
24. Stovall TG, Summit RL Jr, Bran DF, Ling FW. Outpatient vaginal hysterectomy: a pilot study. Obstet Gynecol 1992;80:145-149. [Medline]
25. Dicker RC, Greenspan JR, Strauss LT, et al. Complications of abdominal and vaginal hysterectomy among women of reproductive age in the United States: the Collaborative Review of Sterilization. Am J Obstet Gynecol 1982;144:841-848. [Medline]
26. Wingo PA, Huezo CM, Rubin GL, Ory HW, Peterson HB. The mortality risk associated with hysterectomy. Am J Obstet Gynecol 1985;152:803-808. [Medline]

Abstract PDF Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article PubMed Citation

This article has been cited by other articles:

• Schmeler, K. M., Lynch, H. T., Chen, L.-m., Munsell, M. F., Soliman, P. T., Clark, M. B., Daniels, M. S., White, K. G., Boyd-Rogers, S. G., Conrad, P. G., Yang, K. Y., Rubin, M. M., Sun, C. C., Slomovitz, B. M., Gershenson, D. M., Lu, K. H. (2006). Prophylactic Surgery to Reduce the Risk of Gynecologic Cancers in the Lynch Syndrome. NEJM 354: 261-269 [Abstract] [Full Text]  
• Roumm, A. R., Pizzi, L., Goldfarb, N. I., Cohn, H. (2005). Minimally Invasive: Minimally Reimbursed? An Examination of Six Laparoscopic Surgical Procedures. SURG INNOV 12: 261-287 [Abstract]  
• Pichert, G., Bolliger, B., Buser, K., Pagani, O. (2003). Evidence-based management options for women at increased breast/ovarian cancer risk. Ann Oncol 14: 9-19 [Abstract] [Full Text]  
• Schaffer, J. I., Word, A. (2002). Hysterectomy -- Still a Useful Operation. NEJM 347: 1360-1362 [Full Text]  
• Eisen, A., Rebbeck, T. R., Wood, W. C., Weber, B. L. (2000). Prophylactic Surgery in Women With a Hereditary Predisposition to Breast and Ovarian Cancer. JCO 18: 1980-1995 [Abstract] [Full Text]  
• Porges, R. F., Robinson, J. W., Nisolle, M., Donnez, J., Osborne, N. G., Kadar, N., Reich, H., Liu, C.Y., Garry, R., Dorsey, J. H., Holtz, P. M., Steinberg, E. P., Weber, A. M., Lee, J.-c. (1997). Alternative Techniques of Hysterectomy. NEJM 336: 290-293 [Full Text]  
• Stovall, T. G., Summitt, R. L. (1996). Laparoscopic Hysterectomy -- Is There a Benefit?. NEJM 335: 512-513 [Full Text]