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Previous Volume 336:1335 May 1, 1997 Number 18 Next

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Allopurinol-Induced Orotidinuria — A Test for Mutations at the Ornithine Carbamoyltransferase Locus in Women . Because of an analytic error, the data in Table 1 and Table 2 and Figure 1 and in parts of the Abstract and text were incorrect, as were the calculated specificities and sensitivities. The study was repeated in 21 normal women and 25 obligate heterozygotes. (Each group contained some of the participants in the original study, but no probable heterozygotes were tested.) The new upper limits of urinary orotidine excretion (mean values +3 SD) in normal women are 6.4, 4.8, and 4.7 µmol per millimole of creatinine for the second, third, and fourth periods, respectively. Any value that was higher in one or more of these three periods after administration of allopurinol was considered to be a positive test. Thus, none of the 21 normal women and 22 of the 25 obligate heterozygotes were positive, resulting in a specificity and sensitivity of 100 percent and 88 percent, respectively. The new upper limits of urinary orotic acid excretion (mean values +3 SD) in normal women are 8.0, 4.4, and 3.0 µmol per millimole of creatinine for the second, third, and fourth periods, respectively. None of the 21 normal women and 20 of the 25 obligate heterozygotes were positive, resulting in a specificity and sensitivity of 100 percent and 80 percent, respectively.

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