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Previous Volume 338:962-968 April 2, 1998 Number 14 Next

Abstract PDF Editorial by Hehlmann, R. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Chronic myeloid leukemia can be cured by marrow transplantation from an HLA-identical sibling donor. The use of transplants from unrelated donors is an option for the 70 percent of patients without an HLA-identical sibling, but the morbidity and mortality associated with such transplants have been cause for concern. We analyzed the safety and efficacy of transplants from unrelated donors for the treatment of chronic myeloid leukemia and identified variables that predict a favorable outcome.

Methods Between May 1985 and December 1994, 196 patients with Philadelphia chromosome–positive chronic myeloid leukemia in chronic phase received marrow transplants from unrelated donors.

Results The median follow-up was 5 years (range, 1.2 to 10.1). Graft failure occurred in 5 percent of patients who could be evaluated. Acute graft-versus-host disease of grade III or IV severity was observed in 35 percent of patients who received HLA-matched transplants, and the estimated cumulative incidence of relapse at five years was 10 percent. The Kaplan–Meier estimate of survival at five years was 57 percent. Survival was adversely affected by an interval from diagnosis to transplantation of one year or more, an HLA-DRB1 mismatch, a high body-weight index, and an age of more than 50 years. Survival was improved by the prophylactic use of fluconazole and ganciclovir. The Kaplan–Meier estimate of survival at five years was 74 percent (95 percent confidence interval, 62 to 86 percent) for patients who were 50 years of age or younger who received a transplant from an HLA-matched donor within one year after diagnosis.

Conclusions Transplantation of marrow from an HLA-matched, unrelated donor is safe and effective therapy for selected patients with chronic myeloid leukemia.

Methods

Study Patients and Donors

From May 1985 through December 1994, 196 patients with Philadelphia chromosome–positive chronic myeloid leukemia in chronic phase received a first transplant from an unrelated donor. The diagnosis was confirmed by clinical examination and morphologic and cytogenetic analysis of bone marrow immediately before transplantation.¹ All patients who underwent transplantation according to the protocol described below were included in the analysis. The characteristics of the patients, donors, and grafts are summarized in Table 1. The protocols and consent forms used for these studies were approved by our institutional review board. All patients provided written informed consent. All evaluations were based on data available on December 1, 1997.

View this table: [in this window] [in a new window]   Table 1. Characteristics of 196 Patients with Chronic Myeloid Leukemia in Chronic Phase Who Were Receiving a First Marrow Transplant from an Unrelated Donor and Their Donors.

 
HLA Typing and Donor Matching

The analysis of HLA matching was based on typing for HLA-A and B antigens by serologic methods and retrospective typing for HLA-DRB1 alleles by DNA hybridization with sequence-specific oligonucleotide probes.¹¹ Donors were required to match the recipient for the serologically defined HLA-A, B, and DR antigens and demonstrate compatibility for HLA-Dw on the basis of the mixed-lymphocyte-culture assay.¹² In 1992, matching with the mixed-lymphocyte-culture assay was replaced by typing with sequence-specific oligonucleotide probes for HLA-DRB1 alleles.^13,14 Patients who were 36 to 55 years of age were eligible for transplantation only if a donor matched for HLA-A, B, and Dw or DRB1 was available. A single minor mismatch of HLA-A, B, or DRB1 was allowed for patients under 36 years of age who lacked an HLA-matched donor.^15,16 A pretransplantation lymphocyte cross-matching test with patient serum and donor cells was negative in all cases.

Transplantation Procedures and Supportive Care

Before transplantation all patients followed a regimen that included 60 mg of cyclophosphamide per kilogram of body weight per day for two days and 1200 or >1320 cGy of total-body irradiation, according to the HLA-matching status (Table 1). Donor marrow was not depleted of T cells. Cyclosporine and methotrexate were given for GVHD prophylaxis.¹⁷ Trimethoprim and sulfamethoxazole were given in standard doses for prophylaxis against Pneumocystis carinii pneumonia. From December 1990 through August 1994, all patients were placed in isolation in rooms with laminar air flow and received oral nonabsorbable antibiotics for the prevention of bacterial and fungal infection. After August 1994, patients were nursed in conventional private rooms supplied with positive-pressure filtered air. Systemic antibiotics were administered for the prevention of bacterial infection once the absolute neutrophil count fell below 500 per cubic millimeter.

Patients who were seronegative for cytomegalovirus received blood products from donors who were seronegative for cytomegalovirus or leukocyte-depleted blood products from seropositive donors. From November 16, 1990, through August 8, 1991, patients who were seropositive for cytomegalovirus were randomly assigned to receive ganciclovir or placebo at the time of engraftment for the prevention of cytomegalovirus disease.¹⁸ After August 8, 1991, such patients received ganciclovir as soon as the absolute neutrophil count exceeded 750 per cubic millimeter for two days or as soon as cytomegalovirus antigenemia was detected.¹⁹ From July 1, 1990, through March 1, 1992, all patients were randomly assigned to receive fluconazole or placebo beginning before transplantation and continuing until day 75 after transplantation for the prevention of fungal infection.²⁰ After March 1, 1992, all patients received fluconazole prophylaxis.

Engraftment

Neutrophil engraftment was considered to have occurred on the first of three consecutive days in which the absolute neutrophil count exceeded 500 per cubic millimeter. Platelet engraftment was considered to have occurred on the first of seven consecutive days in which the platelet count exceeded 20,000 per cubic millimeter without platelet transfusions. The presence of donor cells was demonstrated by the detection of informative variable-number tandem-repeat polymorphisms²¹ or by fluorescent in situ hybridization with a Y-chromosome–specific probe in cases of sex-mismatched transplants.²² The analysis of graft failure was limited to patients who survived at least 28 days without relapse of leukemia. Graft failure was defined as the failure to achieve an absolute neutrophil count of more than 500 per cubic millimeter for at least three consecutive days, a decrease in the absolute neutrophil count to below 200 per cubic millimeter for at least three consecutive days after initial engraftment, or documentation of the loss of donor cells by testing with use of informative markers.

Graft-Versus-Host Disease

Acute and chronic GVHD were diagnosed and graded according to standard criteria.^23,24 The probability of clinically extensive chronic GVHD was evaluated in patients who survived for at least 80 days in clinical remission with sustained engraftment.

Relapse

Relapse was defined as clinical evidence of recurrent chronic myeloid leukemia or the detection of a Philadelphia chromosome on at least two occasions after day 50 in a patient with a normal blood-cell differential count and bone marrow morphology. Marrow cytogenetic studies were scheduled on days 28, 56, and 84 and then 6, 12, 18, and 24 months after transplantation.

Karnofsky Performance Scores

The Karnofsky Performance Scale was used to assess the functional capacity of surviving patients at one-year intervals. Scores were analyzed for all assessments made within three months before or after each yearly anniversary.

Statistical Analysis

Cox regression analysis was used to determine the effect of various variables on the end points granulocyte and platelet recovery, acute GVHD of grade III or IV, clinically extensive chronic GVHD, and survival. The variables examined for association with these end points are shown in Table 1. For the purposes of analysis, the patient's age and the interval from diagnosis to transplantation were treated as categorical variables. Categories for relevant variables were assigned before the data were analyzed but were broadened if the data suggested that the results were similar within subcategories. Values for the number of marrow cells transplanted were log-transformed to accommodate extreme upper outliers and then analyzed as a continuous variable. Fluconazole use, ganciclovir use, and cytomegalovirus status were highly correlated and were therefore combined to create a variable with four categories. Because there were relatively few patients with mismatches at the HLA-A or B locus, HLA-matching status was categorized as being identical for HLA-A, B, and DRB1, involving a minor mismatch of HLA-A or B, or involving a minor mismatch of HLA-DRB1.

Cumulative-incidence estimates²⁵ were used for GVHD and relapse, and survival was estimated according to the method of Kaplan and Meier.²⁶ Death without GVHD and relapse, respectively, was considered a competing risk factor for GVHD and relapse, as was relapse for the end points related to GVHD. Multivariable regression models included only variables for which the association with the clinical outcome was significant at the 0.05 level, and data on patients who did not reach an end point were censored at the time of either last contact or failure due to a competing risk factor. Two-sided P values from regression models were derived from the Wald test without adjustment for multiple comparisons. A P value <0.05 and >0.01 was therefore considered suggestive rather than conclusive evidence of an association.

Results

Engraftment

Four patients died before day 28 after transplantation, leaving 192 patients who could be evaluated. Graft failure occurred in 10 patients (5 percent) (Table 2) and included 6 cases of primary graft failure. Three of the 10 patients with graft failure died: 2 on days 40 and 51 from complications of pancytopenia, and 1 on day 1736 with recurrent leukemia. Of the seven patients who survived despite failure of engraftment, two had recovery of autologous hematopoiesis, with recurrent chronic myeloid leukemia, and five underwent a second transplantation. In four of these five patients the second transplant engrafted, and at the most recent follow-up visit, they remained in remission 971, 1196, 1230, and 2168 days after the first transplantation. A logistic-regression analysis suggested that patients who received fewer marrow cells were more likely to have graft failure than those who received a large number of marrow cells (modeled as a continuous variable and adjusted for the recipient's body weight) (P = 0.03; relative risk, 4.9 for each decrement of log₁₀ [1.0x10⁸ cells per kilogram]).

View this table: [in this window] [in a new window]   Table 2. Rates of Survival, Graft Failure, Relapse, and Death without Relapse in Patients Who Underwent Transplantation for Chronic Myeloid Leukemia in Chronic Phase.

 
The median time to neutrophil recovery was 22 days (range, 14 to 51). Neutrophil recovery occurred earlier in patients who received a larger number of marrow cells (P = 0.05; relative risk, 1.5 for each increment of log₁₀ [1.0x10⁸ cells per kilogram]). The median time to platelet recovery was 22 days (range, 5 to 170). The time to platelet recovery was longer in patients who received HLA-DRB1–mismatched transplants than in those who received fully matched transplants (relative risk, 0.5; 95 percent confidence interval, 0.3 to 0.8; P = 0.007), and patients who received a larger number of marrow cells were more likely to have platelet recovery (P = 0.002; relative risk, 1.9 for each increment of log₁₀ [1.0x10⁸ cells per kilogram]).

Graft-Versus-Host Disease

The incidence of acute GVHD of grade II to IV was 77 percent among patients who received transplants matched for HLA-A, B, and DRB1; 89 percent among those with a minor mismatch of HLA-A or B; and 95 percent among those with a minor mismatch of HLA-DRB1. The respective incidence of severe acute GVHD of grade III or IV was 35, 37, and 50 percent in these groups. The cause-specific risk of acute GVHD was not significantly associated with the patient's age, the donor's age, the time from diagnosis to transplantation, or the number of marrow cells transplanted. The association of the sex of patient–donor pairs with the risk of acute GVHD differed according to the extent of the HLA matching (P = 0.003). Among fully matched pairs, male patients who received a marrow graft from a female donor had a higher risk than all other patient–donor pairs (relative risk, 2.5; 95 percent confidence interval, 1.4 to 4.5; P = 0.003). Among pairs with HLA mismatches, GVHD was less likely to develop among male patients than among female patients regardless of the sex of the donor (relative risk, 0.3; 95 percent confidence interval, 0.1 to 0.7; P = 0.01).

The cumulative-incidence estimate of clinically extensive chronic GVHD was 67 percent among the 161 patients who survived without relapse for at least 80 days. The extent of the HLA matching had no detectable association with the cause-specific risk of clinically extensive chronic GVHD. Grafts from women with a history of pregnancy were associated with an increased risk of chronic GVHD as compared with grafts from men (relative risk, 2.0; 95 percent confidence interval, 1.3 to 3.0; P = 0.002). Among 54 patients with clinically extensive chronic GVHD who were still alive with complete follow-up at three years, 19 (35 percent) had discontinued immunosuppressive therapy, and among 25 patients who were still alive at five years, 14 (56 percent) had discontinued immunosuppressive therapy.

Relapse

Clinical or cytogenetic relapse was detected between 39 and 1090 days (median, 253) after transplantation in 15 patients, yielding a cumulative-incidence estimate of 10 percent at 5 years (Table 2). At the most recent follow-up visit, 8 of the 15 patients (53 percent) were alive 315 to 1558 days after transplantation, and 4 were in cytogenetic remission after discontinuing immunosuppressive therapy (1 patient), receiving treatment with interferon (2), or undergoing a second transplantation (1).

Cause of Death

Three patients (2 percent) died from complications of graft failure, and seven patients (4 percent) died from complications of recurrent chronic myeloid leukemia between 53 and 1736 days after transplantation (median, 244). Seventy-six patients (39 percent) died without recurrent chronic myeloid leukemia between 13 and 2590 days after transplantation (median, 142). Death was associated most frequently with treatment-resistant GVHD. Bacterial infection contributed to 19 deaths, and fungal infection (especially aspergillus) to 13. Cytomegalovirus disease contributed to 10 deaths, but only 1 of these occurred after 1992. Death was associated with a lymphoproliferative syndrome in one patient.

Survival

The Kaplan–Meier estimate of survival at five years was 57 percent (95 percent confidence interval, 49 to 64 percent) (Table 2). The median duration of follow-up was 5 years (range, 1.2 to 10.1). A multivariable analysis identified six factors associated with a risk of death: extent of HLA matching, time from diagnosis to transplantation, body-weight index, use of prophylaxis against cytomegalovirus, use of prophylaxis against fungal infections, and age (Table 3). Patients who were over 50 years of age had a significantly higher risk of death than patients who were 21 to 50 years of age (relative risk, 3.4; 95 percent confidence interval, 1.6 to 7.4) (Figure 1 and Table 3).

View this table: [in this window] [in a new window]   Table 3. Multivariable Analysis of Mortality among Patients Who Received a Transplant from an Unrelated Donor for Chronic Myeloid Leukemia in Chronic Phase.

 

View larger version (4K): [in this window] [in a new window]   Figure 1. Probability of Survival in 152 Patients with Chronic Myeloid Leukemia in Chronic Phase Who Received a Transplant Matched for HLA-A, B, and DRB1 from an Unrelated Donor, According to Age. Tick marks represent patients alive at the last follow-up.

 
Patients who were 50 years of age or younger who received transplants matched for HLA-A, B, and DRB1 within one year after diagnosis had a particularly good prognosis. In this subgroup of 51 patients, the probability of surviving five years was 74 percent (95 percent confidence interval, 62 to 86 percent) (Figure 2). The administration of fluconazole for fungal prophylaxis and the administration of ganciclovir to cytomegalovirus-seropositive patients at the time of engraftment or antigenemia increased the probability of survival. After the institution of routine prophylaxis with fluconazole and ganciclovir, estimated survival in this group was 87 percent at three years (30 patients; 95 percent confidence interval, 74 to 99 percent).

View larger version (4K): [in this window] [in a new window]   Figure 2. Probability of Survival in 140 Patients with Chronic Myeloid Leukemia in Chronic Phase Who Were 50 Years Old and Received a Transplant Matched for HLA-A, B, and DRB1 from an Unrelated Donor, According to the Time from Diagnosis to Transplantation. Tick marks represent patients alive at the last follow-up.

 
Karnofsky Performance Scores

One year after transplantation, 36 percent of 119 patients who could be evaluated had a Karnofsky performance score of 100, 70 percent had a score of 90 or more, and 86 percent a score of 80 or more. At three years, 50 percent of 46 patients who could be evaluated had a Karnofsky performance score of 100, 76 percent a score of 90 or more, and 98 percent a score of 80 or more.

Discussion

This study, like others before it, demonstrates that marrow transplantation from an HLA-matched unrelated donor can cure patients with chronic myeloid leukemia in chronic phase. Previous studies, however, have reported that this approach has less favorable results than transplantation from an HLA-identical sibling, most likely because of the higher incidence of severe GVHD among recipients of marrow from unrelated donors.^4,5,6,7,8,9 Nevertheless, we identified a group of patients whose survival compares well with the results in patients who received a transplant from an HLA-identical sibling. Among patients 50 years old or younger who received a graft from an unrelated donor matched for HLA-A, B, and DRB1 within one year after diagnosis, the estimated survival was 74 percent at five years. The probability of survival among patients with chronic myeloid leukemia in chronic phase who receive marrow from an HLA-identical sibling at our center is 77 percent at five years if the transplantation is performed within one year after diagnosis.²⁷

Results of transplantation with marrow from unrelated donors for the treatment of chronic myeloid leukemia have been analyzed in previous studies. Direct comparisons are difficult for several reasons. Selection bias can be introduced by center-specific eligibility criteria, and definitions of end points other than survival have not been standardized. Clinical results might be affected by differences in treatment, especially with regard to the pretransplantation conditioning regimen, T-cell depletion of the marrow, immunosuppression after transplantation, prophylaxis against infection, and other types of supportive care. Moreover, the cumulative-incidence estimates used in this study and the Kaplan–Meier estimates used in previous studies to report outcomes such as graft failure, GVHD, and relapse can yield numerically different results.

In our series, the incidence of graft failure was higher than expected for patients with chronic myeloid leukemia in chronic phase who received a transplant from an HLA-identical sibling.²⁷ Graft failure after marrow transplantation from an unrelated donor has been more frequent among patients with chronic myeloid leukemia than among patients with acute leukemia.²⁸ A previous study has shown that incompatibility for class I HLA alleles, especially HLA-C, increases the risk of graft failure.²⁸

The 10 percent cumulative-incidence estimate of clinical or cytogenetic relapse in this study may be lower than the cumulative incidence of 15 to 20 percent observed after transplantation from an HLA-identical sibling.²⁷ In the current analysis, there was no detectable association between the donor's sex or the extent of HLA mismatching and the cause-specific risk of relapse, although the ability to detect such an association was limited by the small number of relapses.

The sex of the donor and the recipient and a history of pregnancy in donors were identified as risk factors for acute and chronic GVHD in patients who received transplants matched for HLA-A, B, and DRB1 from unrelated donors. These same risk factors have also been reported for transplants from HLA-identical siblings.²⁹ The absence of any detectably increased risk of GVHD in association with a mismatch of HLA-A or B was unexpected in the light of previous results showing that a single disparity in class I HLA alleles increased the risk of GVHD after transplantation from HLA-haploidentical relatives.^30,31 We allowed a disparity of HLA-A or B only within serologically cross-reactive groups of antigens, a selection factor that could have limited the risk of GVHD. The findings that recipients of transplants mismatched for HLA-DRB1 are at increased risk for acute GVHD and death are consistent with those of a previous study.¹¹

The age of the recipient appeared to be a significant variable only for patients over 50 years of age, although the number of patients in this group was small. The overall survival of patients 21 to 36 years of age and 37 to 50 years of age was very similar. This finding argues that eligibility for transplantation should not be routinely limited to patients under 35 or 40 years of age, as is the current practice in some centers.

During the past decade, the results of marrow transplantation have been improved by better supportive care. For patients with chronic myeloid leukemia, this improvement has in turn encouraged transplantation earlier in the course of the disease. Before the advent of ganciclovir as prophylaxis against cytomegalovirus, seropositive patients had a high risk of cytomegalovirus disease, which was frequently fatal. The use of ganciclovir at the time of initial antigenemia early in the course of infection has dramatically diminished the incidence of cytomegalovirus disease and interstitial pneumonia.^18,19 A randomized study likewise showed that prophylaxis with fluconazole decreases the risk of fungal infection and improves survival.²⁰

The duration of disease before transplantation was identified as a predictor of survival in this study. The importance of the time from diagnosis to transplantation was initially recognized in patients with chronic myeloid leukemia who received a transplant from an HLA-identical sibling.^1,32,33 This finding underscores the overall importance of planning treatment and the need to conduct an efficient and timely search for unrelated donors for patients who lack an HLA-identical sibling. Although successful hematopoietic stem-cell transplantation remains the only known cure for patients with chronic myeloid leukemia, the use of interferon has produced clinical and sometimes cytogenetic remission, which can delay the progression of the disease and prolong survival.^34,35,36,37 The choice between interferon therapy and allogeneic stem-cell transplantation can be problematic. Lee et al.³⁸ used decision analytic techniques to compare these options. Their results, based on quality-adjusted life-expectancy data, support the use of early transplantation from unrelated donors for most patients with chronic myeloid leukemia.

Our data on survival and relapse demonstrate that the results of marrow transplantation from HLA-matched, unrelated donors can be similar to those for transplantation from HLA-identical siblings for patients with chronic myeloid leukemia in chronic phase. In the case of transplantation from unrelated donors, the risk of acute GVHD can be minimized in male patients by the use of an HLA-matched male donor, and the risk of chronic GVHD can be minimized in both male and female patients by the use of male donors or female donors who have not been pregnant. Survival can be optimized by performing transplantation early in the course of disease, by matching for HLA-DRB1 alleles, and by the use of fluconazole and ganciclovir for the prevention of fungal and cytomegalovirus infection.

Supported by grants (AI33484, CA15704, CA18029, and CA18221) from the National Institutes of Health.

We are indebted to the physicians and investigators at the Fred Hutchinson Cancer Research Center who participated in this trial: William I. Bensinger, M.D., Eileen M. Bryant, Ph.D., H. Joachim Deeg, M.D., Kris C. Doney, M.D., Mary Flowers, M.D., Richard A. Nash, M.D., Patricia Stewart, M.D., Robert P. Witherspoon, M.D., and Ann Woolfrey, M.D.; and to Jennie Lorenz and Alison Sell for their assistance in the collection of data and preparation of the manuscript.

Source Information

From the Fred Hutchinson Cancer Research Center (J.A.H., T.A.G., P.J.M., F.A., T.R.C., R.A.C., E.W.P., J.R., J.E.S., R.F.S., K.M.S., C.A.), the Veterans Affairs Medical Center (T.R.C.), and the University of Washington School of Medicine (J.A.H., P.J.M., F.A., T.R.C., E.W.P., J.R., J.E.S., R.F.S., K.M.S., C.A.) — all in Seattle.

Address reprint requests to Dr. Hansen at the Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109-1024.

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• Ramirez, P., DiPersio, J. F. (2008). Therapy Options in Imatinib Failures. The Oncologist 13: 424-434 [Abstract] [Full Text]  
• Kawase, T., Morishima, Y., Matsuo, K., Kashiwase, K., Inoko, H., Saji, H., Kato, S., Juji, T., Kodera, Y., Sasazuki, T., for The Japan Marrow Donor Program, (2007). High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. Blood 110: 2235-2241 [Abstract] [Full Text]  
• Hehlmann, R., Berger, U., Pfirrmann, M., Heimpel, H., Hochhaus, A., Hasford, J., Kolb, H.-J., Lahaye, T., Maywald, O., Reiter, A., Hossfeld, D. K., Huber, C., Loffler, H., Pralle, H., Queisser, W., Tobler, A., Nerl, C., Solenthaler, M., Goebeler, M. E., Griesshammer, M., Fischer, T., Kremers, S., Eimermacher, H., Pfreundschuh, M., Hirschmann, W.-D., Lechner, K., Wassmann, B., Falge, C., Kirchner, H. H., Gratwohl, A., for the Schweizerische Arbeitsgemeinschaft fur Kli, (2007). Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia. Blood 109: 4686-4692 [Abstract] [Full Text]  
• Wade, J. A., Katovich Hurley, C., Takemoto, S. K., Thompson, J., Davies, S. M., Fuller, T. C., Rodey, G., Confer, D. L., Noreen, H., Haagenson, M., Kan, F., Klein, J., Eapen, M., Spellman, S., Kollman, C. (2007). HLA mismatching within or outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation. Blood 109: 4064-4070 [Abstract] [Full Text]  
• Sizzano, F., Dametto, E., Amoroso, A. (2007). Evaluation of Alloreactivity in Responder-Stimulator Pairs by Determination of Gamma Interferon-Producing Cells and Cytotoxic-T-Lymphocyte Precursor Frequencies. CVI 14: 481-483 [Abstract] [Full Text]  
• Oehler, V. G., Gooley, T., Snyder, D. S., Johnston, L., Lin, A., Cummings, C. C., Chu, S., Bhatia, R., Forman, S. J., Negrin, R. S., Appelbaum, F. R., Radich, J. P. (2007). The effects of imatinib mesylate treatment before allogeneic transplantation for chronic myeloid leukemia. Blood 109: 1782-1789 [Abstract] [Full Text]  
• Steensma, D. P., Richard, R. E. (2007). Myeloproliferative disorders. ASH-SAP 2007: 172-227 [Full Text]  
• Deeg, H. J., O'Donnell, M., Tolar, J., Agarwal, R., Harris, R. E., Feig, S. A., Territo, M. C., Collins, R. H., McSweeney, P. A., Copelan, E. A., Khan, S. P., Woolfrey, A., Storer, B. (2006). Optimization of conditioning for marrow transplantation from unrelated donors for patients with aplastic anemia after failure of immunosuppressive therapy. Blood 108: 1485-1491 [Abstract] [Full Text]  
• Iacobucci, I., Saglio, G., Rosti, G., Testoni, N., Pane, F., Amabile, M., Poerio, A., Soverini, S., Bassi, S., Cilloni, D., Bassan, R., Breccia, M., Lauria, F., Izzo, B., Merante, S., Frassoni, F., Paolini, S., Montefusco, E., Baccarani, M., Martinelli, G., for the GIMEMA Working Party on Chronic Myeloid Le, (2006). Achieving a Major Molecular Response at the Time of a Complete Cytogenetic Response (CCgR) Predicts a Better Duration of CCgR in Imatinib-Treated Chronic Myeloid Leukemia Patients.. Clin. Cancer Res. 12: 3037-3042 [Abstract] [Full Text]  
• Iacobucci, I., Rosti, G., Amabile, M., Poerio, A., Soverini, S., Cilloni, D., Testoni, N., Abruzzese, E., Montefusco, E., Ottaviani, E., Iuliano, F., Russo, D., Gobbi, M., Alimena, G., Martino, B., Terragna, C., Pane, F., Saglio, G., Baccarani, M., Martinelli, G. (2006). Comparison Between Patients With Philadelphia-Positive Chronic Phase Chronic Myeloid Leukemia Who Obtained a Complete Cytogenetic Response Within 1 Year of Imatinib Therapy and Those Who Achieved Such a Response After 12 Months of Treatment. JCO 24: 454-459 [Abstract] [Full Text]  
• Hess, G., Bunjes, D., Siegert, W., Schwerdtfeger, R., Ledderose, G., Wassmann, B., Kobbe, G., Bornhauser, M., Hochhaus, A., Ullmann, A. J., Kindler, T., Haus, U., Gschaidmeier, H., Huber, C., Fischer, T. (2005). Sustained Complete Molecular Remissions After Treatment With Imatinib-Mesylate in Patients With Failure After Allogeneic Stem Cell Transplantation for Chronic Myelogenous Leukemia: Results of a Prospective Phase II Open-Label Multicenter Study. JCO 23: 7583-7593 [Abstract] [Full Text]  
• Pavletic, S. Z., Khouri, I. F., Haagenson, M., King, R. J., Bierman, P. J., Bishop, M. R., Carston, M., Giralt, S., Molina, A., Copelan, E. A., Ringden, O., Roy, V., Ballen, K., Adkins, D. R., McCarthy, P., Weisdorf, D., Montserrat, E., Anasetti, C. (2005). Unrelated Donor Marrow Transplantation for B-Cell Chronic Lymphocytic Leukemia After Using Myeloablative Conditioning: Results From the Center for International Blood and Marrow Transplant Research. JCO 23: 5788-5794 [Abstract] [Full Text]  
• Chang, G., Orav, E. J., McNamara, T. K., Tong, M.-Y., Antin, J. H. (2005). Psychosocial Function After Hematopoietic Stem Cell Transplantation. Psychosomatics 46: 34-40 [Abstract] [Full Text]  
• Albert, M. H., Yu, X.-Z., Martin, P. J., Anasetti, C. (2005). Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin. Blood 105: 1355-1361 [Abstract] [Full Text]  
• Ilaria, R. L. Jr. (2005). Pathobiology of Lymphoid and Myeloid Blast Crisis and Management Issues. ASH Education Book 2005: 188-194 [Abstract] [Full Text]  
• Takahashi, S., Iseki, T., Ooi, J., Tomonari, A., Takasugi, K., Shimohakamada, Y., Yamada, T., Uchimaru, K., Tojo, A., Shirafuji, N., Kodo, H., Tani, K., Takahashi, T., Yamaguchi, T., Asano, S. (2004). Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood 104: 3813-3820 [Abstract] [Full Text]  
• Laughlin, M. J., Eapen, M., Rubinstein, P., Wagner, J. E., Zhang, M.-J., Champlin, R. E., Stevens, C., Barker, J. N., Gale, R. P., Lazarus, H. M., Marks, D. I., van Rood, J. J., Scaradavou, A., Horowitz, M. M. (2004). Outcomes after Transplantation of Cord Blood or Bone Marrow from Unrelated Donors in Adults with Leukemia. NEJM 351: 2265-2275 [Abstract] [Full Text]  
• Rocha, V., Labopin, M., Sanz, G., Arcese, W., Schwerdtfeger, R., Bosi, A., Jacobsen, N., Ruutu, T., de Lima, M., Finke, J., Frassoni, F., Gluckman, E., the Acute Leukemia Working Party of European Blood, (2004). Transplants of Umbilical-Cord Blood or Bone Marrow from Unrelated Donors in Adults with Acute Leukemia. NEJM 351: 2276-2285 [Abstract] [Full Text]  
• Robien, K., Ulrich, C. M., Bigler, J., Yasui, Y., Gooley, T., Bruemmer, B., Potter, J. D., Radich, J. P. (2004). Methylenetetrahydrofolate Reductase Genotype Affects Risk of Relapse after Hematopoietic Cell Transplantation for Chronic Myelogenous Leukemia. Clin. Cancer Res. 10: 7592-7598 [Abstract] [Full Text]  
• Petersdorf, E. W., Anasetti, C., Martin, P. J., Gooley, T., Radich, J., Malkki, M., Woolfrey, A., Smith, A., Mickelson, E., Hansen, J. A. (2004). Limits of HLA mismatching in unrelated hematopoietic cell transplantation. Blood 104: 2976-2980 [Abstract] [Full Text]  
• Chang, G., Orav, E. J., Tong, M.-Y., Antin, J. H. (2004). Predictors of 1-Year Survival Assessed at the Time of Bone Marrow Transplantation. Psychosomatics 45: 378-385 [Abstract] [Full Text]  
• Flomenberg, N., Baxter-Lowe, L. A., Confer, D., Fernandez-Vina, M., Filipovich, A., Horowitz, M., Hurley, C., Kollman, C., Anasetti, C., Noreen, H., Begovich, A., Hildebrand, W., Petersdorf, E., Schmeckpeper, B., Setterholm, M., Trachtenberg, E., Williams, T., Yunis, E., Weisdorf, D. (2004). Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood 104: 1923-1930 [Abstract] [Full Text]  
• Kantarjian, H. M., Cortes, J. E., O'Brien, S., Luthra, R., Giles, F., Verstovsek, S., Faderl, S., Thomas, D., Garcia-Manero, G., Rios, M. B., Shan, J., Jones, D., Talpaz, M. (2004). Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-{alpha}. Blood 104: 1979-1988 [Abstract] [Full Text]  
• Lee, S. J., Zahrieh, D., Agura, E., MacMillan, M. L., Maziarz, R. T., McCarthy, P. L. Jr, Ho, V. T., Cutler, C., Alyea, E. P., Antin, J. H., Soiffer, R. J. (2004). Effect of up-front daclizumab when combined with steroids for the treatment of acute graft-versus-host disease: results of a randomized trial. Blood 104: 1559-1564 [Abstract] [Full Text]  
• Stone, R. M. (2004). Optimizing Treatment of Chronic Myeloid Leukemia: A Rational Approach. The Oncologist 9: 259-270 [Abstract] [Full Text]  
• Robien, K., Schubert, M. M., Bruemmer, B., Lloid, M. E., Potter, J. D., Ulrich, C. M. (2004). Predictors of Oral Mucositis in Patients Receiving Hematopoietic Cell Transplants for Chronic Myelogenous Leukemia. JCO 22: 1268-1275 [Abstract] [Full Text]  
• Boeckh, M., Nichols, W. G. (2004). The impact of cytomegalovirus serostatus of donor and recipient before hematopoietic stem cell transplantation in the era of antiviral prophylaxis and preemptive therapy. Blood 103: 2003-2008 [Abstract] [Full Text]  
• Marr, K. A., Leisenring, W., Crippa, F., Slattery, J. T., Corey, L., Boeckh, M., McDonald, G. B. (2004). Cyclophosphamide metabolism is affected by azole antifungals. Blood 103: 1557-1559 [Abstract] [Full Text]  
• Maris, M. B., Niederwieser, D., Sandmaier, B. M., Storer, B., Stuart, M., Maloney, D., Petersdorf, E., McSweeney, P., Pulsipher, M., Woolfrey, A., Chauncey, T., Agura, E., Heimfeld, S., Slattery, J., Hegenbart, U., Anasetti, C., Blume, K., Storb, R. (2003). HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with hematologic malignancies. Blood 102: 2021-2030 [Abstract] [Full Text]  
• Deininger, M. W. N., Druker, B. J. (2003). Specific Targeted Therapy of Chronic Myelogenous Leukemia with Imatinib. Pharmacol. Rev. 55: 401-423 [Abstract] [Full Text]  
• Antin, J. H., Kim, H. T., Cutler, C., Ho, V. T., Lee, S. J., Miklos, D. B., Hochberg, E. P., Wu, C. J., Alyea, E. P., Soiffer, R. J. (2003). Sirolimus, tacrolimus, and low-dose methotrexate for graft-versus-host disease prophylaxis in mismatched related donor or unrelated donor transplantation. Blood 102: 1601-1605 [Abstract] [Full Text]  
• Cwynarski, K., Roberts, I. A. G., Iacobelli, S., van Biezen, A., Brand, R., Devergie, A., Vossen, J. M., Aljurf, M., Arcese, W., Locatelli, F., Dini, G., Niethammer, D., Niederwieser, D., Apperley, J. F. (2003). Stem cell transplantation for chronic myeloid leukemia in children. Blood 102: 1224-1231 [Abstract] [Full Text]  
• Ottinger, H. D., Ferencik, S., Beelen, D. W., Lindemann, M., Peceny, R., Elmaagacli, A. H., Husing, J., Grosse-Wilde, H. (2003). Hematopoietic stem cell transplantation: contrasting the outcome of transplantations from HLA-identical siblings, partially HLA-mismatched related donors, and HLA-matched unrelated donors. Blood 102: 1131-1137 [Abstract] [Full Text]  
• Grewal, S. S., Barker, J. N., Davies, S. M., Wagner, J. E. (2003). Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood?. Blood 101: 4233-4244 [Full Text]  
• Cortes, J. E., Talpaz, M., Giles, F., O'Brien, S., Rios, M. B., Shan, J., Garcia-Manero, G., Faderl, S., Thomas, D. A., Wierda, W., Ferrajoli, A., Jeha, S., Kantarjian, H. M. (2003). Prognostic significance of cytogenetic clonal evolution in patients with chronic myelogenous leukemia on imatinib mesylate therapy. Blood 101: 3794-3800 [Abstract] [Full Text]  
• McDonald, G. B., Slattery, J. T., Bouvier, M. E., Ren, S., Batchelder, A. L., Kalhorn, T. F., Schoch, H. G., Anasetti, C., Gooley, T. (2003). Cyclophosphamide metabolism, liver toxicity, and mortality following hematopoietic stem cell transplantation. Blood 101: 2043-2048 [Abstract] [Full Text]  
• Niederwieser, D., Maris, M., Shizuru, J. A., Petersdorf, E., Hegenbart, U., Sandmaier, B. M., Maloney, D. G., Storer, B., Lange, T., Chauncey, T., Deininger, M., Ponisch, W., Anasetti, C., Woolfrey, A., Little, M.-T., Blume, K. G., McSweeney, P. A., Storb, R. F. (2003). Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissions in patients with hematological diseases. Blood 101: 1620-1629 [Abstract] [Full Text]  
• Lang, P., Handgretinger, R., Niethammer, D., Schlegel, P. G., Schumm, M., Greil, J., Bader, P., Engel, C., Scheel-Walter, H., Eyrich, M., Klingebiel, T. (2003). Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia. Blood 101: 1630-1636 [Abstract] [Full Text]  
• Finke, J., Schmoor, C., Lang, H., Potthoff, K., Bertz, H. (2003). Matched and Mismatched Allogeneic Stem-Cell Transplantation From Unrelated Donors Using Combined Graft-Versus-Host Disease Prophylaxis Including Rabbit Anti-T Lymphocyte Globulin. JCO 21: 506-513 [Abstract] [Full Text]  
• Boeckh, M., Leisenring, W., Riddell, S. R., Bowden, R. A., Huang, M.-L., Myerson, D., Stevens-Ayers, T., Flowers, M. E. D., Cunningham, T., Corey, L. (2003). Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity. Blood 101: 407-414 [Abstract] [Full Text]  
• Melo, J. V., Hughes, T. P., Apperley, J. F. (2003). Chronic Myeloid Leukemia. ASH Education Book 2003: 132-152 [Abstract] [Full Text]  
• Marr, K. A., Carter, R. A., Boeckh, M., Martin, P., Corey, L. (2002). Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood 100: 4358-4366 [Abstract] [Full Text]  
• Tan, P., Mitchell, D. A., Buss, T. N., Holmes, M. A., Anasetti, C., Foote, J. (2002). "Superhumanized" Antibodies: Reduction of Immunogenic Potential by Complementarity-Determining Region Grafting with Human Germline Sequences: Application to an Anti-CD28. J. Immunol. 169: 1119-1125 [Abstract] [Full Text]  
• Ablashi, D. V., Chatlynne, L. G., Whitman, J. E. Jr., Cesarman, E. (2002). Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases. Clin. Microbiol. Rev. 15: 439-464 [Abstract] [Full Text]  
• Kantarjian, H. M., Talpaz, M., O'Brien, S., Smith, T. L., Giles, F. J., Faderl, S., Thomas, D. A., Garcia-Manero, G., Issa, J.-P. J., Andreeff, M., Kornblau, S. M., Koller, C., Beran, M., Keating, M., Rios, M. B., Shan, J., Resta, D., Capdeville, R., Hayes, K., Albitar, M., Freireich, E. J., Cortes, J. E. (2002). Imatinib Mesylate for Philadelphia Chromosome-positive, Chronic-Phase Myeloid Leukemia after Failure of Interferon-{alpha}: Follow-Up Results. Clin. Cancer Res. 8: 2177-2187 [Abstract] [Full Text]  
• Morishima, Y., Sasazuki, T., Inoko, H., Juji, T., Akaza, T., Yamamoto, K., Ishikawa, Y., Kato, S., Sao, H., Sakamaki, H., Kawa, K., Hamajima, N., Asano, S., Kodera, Y. (2002). The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood 99: 4200-4206 [Abstract] [Full Text]  
• Copelan, E. A., Goldman, J. M., Druker, B. J. (2002). Treatment options in chronic myelogenous leukemia. Blood 99: 3070-3071 [Full Text]  
• Castro-Malaspina, H., Harris, R. E., Gajewski, J., Ramsay, N., Collins, R., Dharan, B., King, R., Deeg, H. J. (2002). Unrelated donor marrow transplantation for myelodysplastic syndromes: outcome analysis in 510 transplants facilitated by the National Marrow Donor Program. Blood 99: 1943-1951 [Abstract] [Full Text]  
• Weisdorf, D. J., Anasetti, C., Antin, J. H., Kernan, N. A., Kollman, C., Snyder, D., Petersdorf, E., Nelson, G., McGlave, P. (2002). Allogeneic bone marrow transplantation for chronic myelogenous leukemia: comparative analysis of unrelated versus matched sibling donor transplantation. Blood 99: 1971-1977 [Abstract] [Full Text]  
• Savage, D. G., Antman, K. H. (2002). Imatinib Mesylate -- A New Oral Targeted Therapy. NEJM 346: 683-693 [Full Text]  
• Elmaagacli, A. H., Basoglu, S., Peceny, R., Trenschel, R., Ottinger, H., Lollert, A., Runde, V., Grosse-Wilde, H., Beelen, D. W., Schaefer, U. W. (2002). Improved disease-free-survival after transplantation of peripheral blood stem cells as compared with bone marrow from HLA-identical unrelated donors in patients with first chronic phase chronic myeloid leukemia. Blood 99: 1130-1135 [Abstract] [Full Text]  
• Drobyski, W. R., Klein, J., Flomenberg, N., Pietryga, D., Vesole, D. H., Margolis, D. A., Keever-Taylor, C. A. (2002). Superior survival associated with transplantation of matched unrelated versus one-antigen-mismatched unrelated or highly human leukocyte antigen- disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies: establishing a treatment algorithm for recipients of alternative donor grafts. Blood 99: 806-814 [Abstract] [Full Text]  
• Druker, B. J., O'Brien, S. G., Cortes, J., Radich, J. (2002). Chronic Myelogenous Leukemia. ASH Education Book 2002: 111-135 [Abstract] [Full Text]  
• Petersdorf, E. W., Hansen, J. A., Martin, P. J., Woolfrey, A., Malkki, M., Gooley, T., Storer, B., Mickelson, E., Smith, A., Anasetti, C. (2001). Major-Histocompatibility-Complex Class I Alleles and Antigens in Hematopoietic-Cell Transplantation. NEJM 345: 1794-1800 [Abstract] [Full Text]  
• Lee, S. J., Klein, J. P., Anasetti, C., Antin, J. H., Loberiza, F. R., Bolwell, B. J., LeMaistre, C. F., Litzow, M. R., Marks, D., Waller, E. K., Matlack, M., Giralt, S., Horowitz, M. M. (2001). The effect of pretransplant interferon therapy on the outcome of unrelated donor hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in first chronic phase. Blood 98: 3205-3211 [Abstract] [Full Text]  
• Petersdorf, E. W., Kollman, C., Hurley, C. K., Dupont, B., Nademanee, A., Begovich, A. B., Weisdorf, D., McGlave, P. (2001). Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia: the US National Marrow Donor Program Experience. Blood 98: 2922-2929 [Abstract] [Full Text]  
• Bacigalupo, A., Lamparelli, T., Bruzzi, P., Guidi, S., Alessandrino, P. E., di Bartolomeo, P., Oneto, R., Bruno, B., Barbanti, M., Sacchi, N., Van Lint, M. T., Bosi, A. (2001). Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO). Blood 98: 2942-2947 [Abstract] [Full Text]  
• Bonifazi, F., de Vivo, A., Rosti, G., Guilhot, F., Guilhot, J., Trabacchi, E., Hehlmann, R., Hochhaus, A., Shepherd, P. C. A., Steegmann, J. L., Kluin-Nelemans, H. C., Thaler, J., Simonsson, B., Louwagie, A., Reiffers, J., Mahon, F. X., Montefusco, E., Alimena, G., Hasford, J., Richards, S., Saglio, G., Testoni, N., Martinelli, G., Tura, S., Baccarani, M. (2001). Chronic myeloid leukemia and interferon-alpha : a study of complete cytogenetic responders. Blood 98: 3074-3081 [Abstract] [Full Text]  
• Sanz, G. F., Saavedra, S., Planelles, D., Senent, L., Cervera, J., Barragan, E., Jimenez, C., Larrea, L., Martin, G., Martinez, J., Jarque, I., Moscardo, F., Plume, G., Andreu, R., Regadera, A. I., Garcia, I., Molla, S., Solves, P., de la Rubia, J., Bolufer, P., Benlloch, L., Soler, M. A., Marty, M. L., Sanz, M. A. (2001). Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood 98: 2332-2338 [Abstract] [Full Text]  
• Krcmery, V., Huttova, M., Mateicka, F., Laho, L., Jurga, L., Ondrusova, A., Tarekova, Z., Kralinsky, K., Hanzen, J., Liskova, A., Mrazova, M., Sabo, A., Pisarcikova, M., Kovacicova, G., Chovancova, D., Szovenyiova, Z. (2001). Breakthrough fungaemia in neonates and infants caused by Candida albicans and Candida parapsilosis susceptible to fluconazole in vitro. J Antimicrob Chemother 48: 521-525 [Abstract] [Full Text]  
• Kollman, C., Howe, C. W. S., Anasetti, C., Antin, J. H., Davies, S. M., Filipovich, A. H., Hegland, J., Kamani, N., Kernan, N. A., King, R., Ratanatharathorn, V., Weisdorf, D., Confer, D. L. (2001). Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 98: 2043-2051 [Abstract] [Full Text]  
• Alpdogan, O., Schmaltz, C., Muriglan, S. J., Kappel, B. J., Perales, M.-A., Rotolo, J. A., Halm, J. A., Rich, B. E., van den Brink, M. R. M. (2001). Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood 98: 2256-2265 [Abstract] [Full Text]  
• Bunjes, D., Buchmann, I., Duncker, C., Seitz, U., Kotzerke, J., Wiesneth, M., Dohr, D., Stefanic, M., Buck, A., Harsdorf, S. V., Glatting, G., Grimminger, W., Karakas, T., Munzert, G., Dohner, H., Bergmann, L., Reske, S. N. (2001). Rhenium 188-labeled anti-CD66 (a, b, c, e) monoclonal antibody to intensify the conditioning regimen prior to stem cell transplantation for patients with high-risk acute myeloid leukemia or myelodysplastic syndrome: results of a phase I-II study. Blood 98: 565-572 [Abstract] [Full Text]  
• Ulrich, C. M., Yasui, Y., Storb, R., Schubert, M. M., Wagner, J. L., Bigler, J., Ariail, K. S., Keener, C. L., Li, S., Liu, H., Farin, F. M., Potter, J. D. (2001). Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism. Blood 98: 231-234 [Abstract] [Full Text]  
• Laughlin, M. J., Barker, J., Bambach, B., Koc, O. N., Rizzieri, D. A., Wagner, J. E., Gerson, S. L., Lazarus, H. M., Cairo, M., Stevens, C. E., Rubinstein, P., Kurtzberg, J. (2001). Hematopoietic Engraftment and Survival in Adult Recipients of Umbilical-Cord Blood from Unrelated Donors. NEJM 344: 1815-1822 [Abstract] [Full Text]  
• Soiffer, R. J., Weller, E., Alyea, E. P., Mauch, P., Webb, I. L., Fisher, D. C., Freedman, A. S., Schlossman, R. L., Gribben, J., Lee, S., Anderson, K. C., Marcus, K., Stone, R. M., Antin, J. H., Ritz, J. (2001). CD6+ Donor Marrow T-Cell Depletion as the Sole Form of Graft-Versus-Host Disease Prophylaxis in Patients Undergoing Allogeneic Bone Marrow Transplant From Unrelated Donors. JCO 19: 1152-1159 [Abstract] [Full Text]  
• Druker, B. J., Sawyers, C. L., Capdeville, R., Ford, J. M., Baccarani, M., Goldman, J. M. (2001). Chronic Myelogenous Leukemia. ASH Education Book 2001: 87-112 [Abstract] [Full Text]  
• Marr, K. A., Seidel, K., Slavin, M. A., Bowden, R. A., Schoch, H. G., Flowers, M. E. D., Corey, L., Boeckh, M. (2000). Prolonged fluconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: long-term follow-up of a randomized, placebo-controlled trial. Blood 96: 2055-2061 [Abstract] [Full Text]  
• Nash, R. A., Antin, J. H., Karanes, C., Fay, J. W., Avalos, B. R., Yeager, A. M., Przepiorka, D., Davies, S., Petersen, F. B., Bartels, P., Buell, D., Fitzsimmons, W., Anasetti, C., Storb, R., Ratanatharathorn, V. (2000). Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors. Blood 96: 2062-2068 [Abstract] [Full Text]  
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