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Previous Volume 344:1804 June 7, 2001 Number 23

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Estrogen and the Risk of Breast Cancer . On page 276, the sentence that begins 11 lines from the bottom of the right-hand column should have read, "Flaxseed is a rich dietary source of both mammalian lignans and -linolenic acid, which exert antiestrogenic effects by both binding to the estrogen receptor and inhibiting the synthesis of estrogen.³⁴" On page 278, Figure 1 and its legend contained errors. The corrected figure is reprinted with its legend below. On page 279, the last sentence in the right-hand column should have read, "The 2-hydroxy metabolites are converted to anticarcinogenic methoxylated metabolites (2-methoxyestrone and 2-methoxyestradiol, 2-hydroxyestrone and 2-hydroxyestradiol 3-methyl ether) by catechol O-methyltransferase."

View larger version (43K): [in this window] [in a new window]   Figure 1. Pathways of Estrogen Synthesis and Catabolism and the Sensitivity of Tissue to Estrogens. 3-HSD denotes 3-hydroxysteroid dehydrogenase, 17-HSD 17-hydroxysteroid dehydrogenase, DHEA dehydroepiandrosterone, P-450 cytochrome P-450, scc side-chain–cleavage enzyme, CYP17 17-hydroxylase, CYP21 21-hydroxylase, CYP11 11-hydroxylase, CYP19 P-450 aromatase, E1 estrone, E2 estradiol, 2-OH-E1 2-hydroxyestrone, 2-OH-E2 2-hydroxyestradiol, 2-MeO-E1 2-methoxyestrone, 2-MeO-E2 2-methoxyestradiol, 2-OH-3-MeO-E1 2-hydroxyestrone 3-methyl ether, 2-OH-3-MeO-E2 2-hydroxyestradiol 3-methyl ether, 4-OH-E1 4-hydroxyestrone, 4-OH-E2 4-hydroxyestradiol, 4-OH-3-MeO-E1 4-hydroxyestrone 3-methyl ether, 4-OH-3-MeO-E2 4-hydroxyestradiol 3-methyl ether, 16-OH-E1 16-hydroxyestrone, 16-OH-E2 16-hydroxyestradiol, CYP1A1 cytochrome P-450 1A1, CYP1B1 cytochrome P-450 1B1, and COMT catechol O-methyltransferase.

 

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