Psychological Sequelae of the September 11 Terrorist Attacks in New York City
Sandro Galea, M.D., M.P.H., Jennifer Ahern, M.P.H., Heidi Resnick, Ph.D., Dean Kilpatrick, Ph.D., Michael Bucuvalas, Ph.D., Joel Gold, M.D., and David Vlahov, Ph.D.
Background The scope of the terrorist attacks of September 11,2001, was unprecedented in the United States. We assessed theprevalence and correlates of acute post-traumatic stress disorder(PTSD) and depression among residents of Manhattan five to eightweeks after the attacks.
Methods We used random-digit dialing to contact a representativesample of adults living south of 110th Street in Manhattan.Participants were asked about demographic characteristics, exposureto the events of September 11, and psychological symptoms afterthe attacks.
Results Among 1008 adults interviewed, 7.5 percent reportedsymptoms consistent with a diagnosis of current PTSD relatedto the attacks, and 9.7 percent reported symptoms consistentwith current depression (with "current" defined as occurringwithin the previous 30 days). Among respondents who lived southof Canal Street (i.e., near the World Trade Center), the prevalenceof PTSD was 20.0 percent. Predictors of PTSD in a multivariatemodel were Hispanic ethnicity, two or more prior stressors,a panic attack during or shortly after the events, residencesouth of Canal Street, and loss of possessions due to the events.Predictors of depression were Hispanic ethnicity, two or moreprior stressors, a panic attack, a low level of social support,the death of a friend or relative during the attacks, and lossof a job due to the attacks.
Conclusions There was a substantial burden of acute PTSD anddepression in Manhattan after the September 11 attacks. Experiencesinvolving exposure to the attacks were predictors of currentPTSD, and losses as a result of the events were predictors ofcurrent depression. In the aftermath of terrorist attacks, theremay be substantial psychological morbidity in the population.
The attacks of September 11, 2001, represented the largest actof terrorism in U.S. history. Approximately 3000 people werekilled in New York City alone.1 Severe lasting psychologicaleffects are generally seen after disasters causing extensiveloss of life, property damage, and widespread financial strainand after disasters that are intentionally caused.2 These elementswere all present in the September 11 attacks, suggesting thatthe psychological sequelae in New York City are substantialand will be long-lasting.
We conducted a study to determine the prevalence of psychopathologicdisorders in Manhattan after September 11 and to identify predictorsof these conditions. We focused on post-traumatic stress disorder(PTSD) and depression, the two most commonly studied psychologicalsequelae of trauma and disasters.3,4,5
Methods
Data Collection and Sample
Data were collected through telephone interviews with a randomsample of Manhattan residents between October 16 and November15, 2001. The institutional review board of the New York Academyof Medicine approved the study, and oral informed consent wasobtained from the study subjects.
The sampling frame consisted of adults living in householdswith telephones in Manhattan. We restricted the sample to householdssouth of 110th Street, a demographically homogeneous area andthe part of Manhattan that is closest to the World Trade Center(Figure 1). Using random-digit dialing, we screened householdsfor geographic eligibility, and an adult in each household wasrandomly selected to be interviewed (whoever had the most recentbirthday was selected). We made up to 10 attempts to contactan adult at each number. The overall cooperation rate for thesurvey was 64.3 percent.
Figure 1. Sampling Frame in Relation to the Site of the World Trade Center.
The sampling frame includes the area between 110th Street and Canal Street (yellow), and the area south of Canal Street (orange).
Study Instruments
Respondents were asked questions from a structured questionnairein English or Spanish. We asked questions about demographiccharacteristics, where the respondent was living before September11, and the respondent's location during the attacks. For theanalyses, total social support was categorized as low, medium,or high. We asked about three aspects of social support emotional (i.e., "someone to love you and make you feel wanted"),instrumental (i.e., "someone to help you if you were confinedto bed"), and appraisal (i.e., "someone to give you good advicein a crisis") in the six months before September 11.6We also asked whether the respondent had experienced any ofeight stressful events (e.g., the death of a spouse) in theprevious year.
Respondents were asked whether they had directly witnessed theattacks, had feared they would die during the attacks, had friendsor relatives who were killed during the attacks, had been displacedfrom home, had been involved in the rescue effort, or had losta job or possessions because of the attacks. Documentation ofa panic attack was based on a modified version of the NationalInstitute of Mental Health Diagnostic Interview Schedule; thediagnosis required the development of at least four characteristicsymptoms during or soon after the attacks.
PTSD was assessed with the use of the PTSD questionnaire fromthe National Women's Study, which is a modified version of theDiagnostic Interview Schedule for PTSD. For the diagnosis ofcurrent PTSD, this instrument has a coefficient of 0.71 foragreement with clinician-administered structured clinical interviews,and it uses a nonevent-specific approach to the assessmentof PTSD symptoms.5 Current PTSD was defined as the presenceof at least one recurrent symptom (e.g., intrusive memoriesor distressing dreams), three avoidance symptoms (e.g., effortsto avoid thoughts associated with the trauma or loss of interestin activities associated with it), and two symptoms of hyperarousal(e.g., difficulty falling asleep or concentrating). All symptomsmust have persisted for 2 weeks or longer and must have beenpresent within the previous 30 days to qualify as symptoms ofcurrent PTSD. In addition, for symptoms that involved specificcontent (e.g., memories or thoughts), we asked about the content;these symptoms had to be related to the September 11 attacksto qualify as symptoms of current PTSD. We used a modified,validated version of the Structured Clinical Interview in theDiagnostic and Statistical Manual of Mental Disorders, fourthedition, for a major depressive episode to determine the presenceof depression within the previous 30 days.7
Statistical Analysis
We calculated both the overall prevalences of current PTSD anddepression and the prevalences according to covariates of interest.Two-tailed chi-square tests were used to identify associationsbetween covariates and either PTSD or depression. Multiple logisticregression was used to examine predictors separately for PTSDand depression. Covariates were considered in a multivariateregression model in which bivariate chi-square P values wereless than 0.1. Differences in log likelihood (P<0.05) wereused to determine whether variables would be retained in subsequentmodels. We tested for interactions between key predictor variablesin the final models. Analyses were weighted to compensate forpotential bias due to the number of adults in a household andthe number of telephones. We used SUDAAN software to adjustall analyses for weighting.8
Results
Sample
Of the 1008 adults surveyed, 20 were excluded from the analysisbecause of missing weight variables (i.e., the number of adultsor the number of telephones in the household). Overall, 52.0percent of the respondents were women, and 71.6 percent werewhite; the mean (±SD) age was 42±15 years. Age,sex, race or ethnic group, and residence distributions in oursample were similar to estimates obtained from the 2000 U.S.Census for our sampling frame.9 On September 11, 5.2 percentof the respondents lived south of Canal Street.
Prevalence of PTSD and Depression
The prevalence of PTSD was 7.5 percent (95 percent confidenceinterval, 5.7 to 9.3 percent), and the prevalence of depressionwas 9.7 percent (95 percent confidence interval, 7.3 to 11.3percent). Overall, 13.6 percent of the respondents reportedsymptoms that met the criteria for either PTSD or depression,and 3.7 percent reported symptoms that met the criteria forboth disorders.
Bivariate Analyses
Table 1 shows the results of bivariate analyses. The covariatesassociated with whether the respondent had PTSD were sex (P=0.005),residence before the attacks (P=0.04), level of social support(P=0.01), number of stressors in the 12 months before September11 (P<0.001), whether the respondent witnessed the events(P=0.01), whether the respondent had a panic attack during orsoon after the events (P<0.001), whether possessions werelost (P=0.01), whether the respondent was involved in the rescueeffort (P=0.03), and whether the respondent lost a job becauseof the attacks (P=0.005).
Table 1. Bivariate Associations between Characteristics of the Respondents and Current Post-Traumatic Stress Disorder (PTSD) or Depression.
Covariates associated with whether the respondent had depressionwere sex (P=0.03), race or ethnic group (P=0.03), yearly householdincome (P=0.006), level of education (P=0.007), level of socialsupport (P<0.001), number of stressors in the 12 months beforeSeptember 11 (P<0.001), whether the respondent had a panicattack during or soon after the events (P<0.001), whethera friend or relative died during the attacks (P=0.04), and whetherthe respondent lost a job because of the attacks (P=0.006).
Multivariate Analyses
In a multivariate logistic-regression model (Table 2), significantpredictors of PTSD were Hispanic ethnicity as compared withwhite race (odds ratio, 2.6), two or more stressors in the 12months before September 11 as compared with none (odds ratio,5.5), a panic attack (odds ratio, 7.6), residence south of CanalStreet before the attacks (odds ratio, 2.9), and loss of possessionsdue to the attacks (odds ratio, 5.6). The significant predictorsof depression were Hispanic ethnicity (odds ratio, 3.2), twoor more stressors in the 12 months before September 11 (oddsratio, 3.4), a panic attack (odds ratio, 2.6), a low as comparedwith a high level of social support (odds ratio, 2.4), the deathof a friend or relative in the attacks (odds ratio, 2.3), andloss of a job because of the attacks (odds ratio, 2.8).
Table 2. Multivariate Associations between Characteristics of the Respondents and Current Post-Traumatic Stress Disorder (PTSD) or Depression.
Discussion
In our survey of a representative sample of adults living southof 110th Street in Manhattan, conducted five to eight weeksafter the September 11 attacks, 7.5 percent of the respondentsreported symptoms consistent with the diagnosis of current PTSD,and 9.7 percent reported symptoms consistent with the diagnosisof current depression. These prevalences suggest that in thearea below 110th Street approximately 67,000 persons had PTSDand approximately 87,000 had depression during the time of thestudy.9 Although the estimated prevalences of current psychopathologyvary according to the population studied, in a benchmark nationalstudy, the prevalence of PTSD within the previous year was 3.6percent,10 and the prevalence of depression within the previous30 days was 4.9 percent,11 suggesting that the prevalences inour survey were approximately twice the base-line values.
The prevalence of psychological sequelae of disasters has beendocumented in only a few community-based samples, and comparisonof the findings is limited by differences in sampling framesand the interval between the event and the assessment. Usingoutcome measures that were similar to ours, Hanson et al. reportedthat the overall prevalence of PTSD was 4.1 percent six monthsafter the 1992 civil disturbances in Los Angeles County.12 Theprevalence of depression in our study is similar to that reportedafter floods (9.5 percent).13
Persons directly affected by disasters have higher rates ofpost-event psychiatric disorders than persons indirectly affected.14,15Our survey showed that the prevalence of PTSD was higher amongthe persons who were most directly exposed to the attacks ortheir consequences (e.g., those living south of Canal Street,the area closest to the attacks, and those who lost possessions)than among persons with less direct exposure. Factors associatedwith grief (e.g., loss of a family member) increased the likelihoodof depression, a finding that is consistent with the resultsof previous studies.16,17
We found bivariate associations between female sex and bothPTSD and depression, a finding that is consistent with the resultsof most studies.3,16,18 However, our adjusted models suggestedthat other factors may have been important mediators of theassociation between sex and psychopathology after this disaster.For example, the level of social support may have influencedthe association between sex and depression.
Hispanic ethnicity was associated with both PTSD and depression,and the association was independent of other covariates. Althoughthe relation between membership in a minority group and psychopathologyafter a disaster has been suggested in previous studies,19 fewhave specifically examined the role of Hispanic ethnicity.20Research with veterans of the Vietnam War has shown that Hispanicsmay have a higher prevalence of PTSD than persons of other racialor ethnic backgrounds.21 Sociocultural influences have beenproposed as mediators of this relation.22
We also found a relation between a low level of social supportand both PTSD and depression in bivariate analyses and betweena low level of social support and depression in adjusted analyses.Social ties have a positive role in mental health.23 After adisaster, a low level of social support has been shown to berelated to PTSD and depressive symptoms.24,25
Our study provides strong evidence of an association betweeninitial panic symptoms and subsequent psychopathology. Althoughthe prognostic role of panic symptoms in determining the riskof PTSD or depression cannot be determined from a cross-sectionalsurvey, this finding is consistent with previous research documentingassociations between initial emotional responses to trauma andthe development of PTSD.26,27 These findings suggest that interventionsaddressing such initial reactions to a disaster may help preventthe development of long-lasting psychological sequelae.28
Prospective evaluations of PTSD in trauma victims and in thegeneral population suggest that the symptoms of PTSD decreasesubstantially within three months after a traumatic experience29but that up to a third of cases of PTSD may not fully remit.3,30How long the psychological sequelae of the September 11 attackswill last remains to be seen, and it is possible that the prevalenceof symptoms in our study reflects transient stress reactionsto some degree. However, the ongoing threat of terrorist attacksmay affect both the severity and the duration of these psychologicalsymptoms.31 More than 100,000 persons in New York City may losetheir jobs as a result of the September 11 attacks,32 and thecleanup efforts and disruption of services throughout the citywill continue for a long time. In this context, the high prevalenceof psychopathology that we documented among the residents ofManhattan is not surprising. Future research in New York Cityshould determine the prognostic role of the factors that wereassociated with PTSD and depression in our study.
Supported by grants from the United Way of New York City, theNew York Community Trust, and the National Institute on DrugAbuse (R01 DA14219-01S1).
We are indebted to Mr. Mark Morgan for invaluable contributionsto the conduct of this study; to Dr. Joseph Boscarino for ongoingfeedback; to Dr. Donald Hoover for statistical assistance; toDr. Neal Cohen, Commissioner of Health for the New York CityDepartment of Health, and Mr. Len McNally of the New York CommunityTrust, for their encouragement; to the interviewers at Schulman,Ronca, and Bucuvalas; and to all the persons who participatedin the study during a difficult time for New Yorkers.
Source Information
From the Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York (S.G., J.A., J.G., D.V.); the Department of Epidemiology, Columbia University Mailman School of Public Health, New York (S.G., D.V.); the National Crime Victims' Research and Treatment Center, Medical University of South Carolina, Charleston (H.R., D.K.); Schulman, Ronca, and Bucuvalas, New York (M.B.); and Bellevue Hospital Center, New York (J.G.).
Address reprint requests to Dr. Galea at the Center for Urban Epidemiologic Studies, Rm. 556, New York Academy of Medicine, 1216 Fifth Ave., New York, NY 10029-5283, or at sgalea{at}nyam.org.
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Covell, N. H., Donahue, S. A., Allen, G., Foster, M. J., Felton, C. J., Essock, S. M.
(2006). Use of Project Liberty Counseling Services Over Time by Individuals in Various Risk Categories. Psychiatr. Serv.
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Jackson, C. T., Allen, G., Essock, S. M., Foster, M. J., Lanzara, C. B., Felton, C. J., Donahue, S. A.
(2006). Clusters of Event Reactions Among Recipients of Project Liberty Mental Health Counseling. Psychiatr. Serv.
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Jackson, C. T., Covell, N. H., Shear, K. M., Zhu, C., Donahue, S. A., Essock, S. M., Felton, C. J.
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Shear, K. M., Jackson, C. T., Essock, S. M., Donahue, S. A., Felton, C. J.
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Donahue, S. A., Jackson, C. T., Shear, K. M., Felton, C. J., Essock, S. M.
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Gomes, C., McGuire, T. G., Foster, M. J., Donahue, S. A., Felton, C. J., Essock, S. M.
(2006). Did Project Liberty Displace Community-Based Medicaid Services in New York?. Psychiatr. Serv.
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Covell, N. H., Essock, S. M., Felton, C. J., Donahue, S. A.
(2006). Characteristics of Project Liberty Clients That Predicted Referrals to Intensive Mental Health Services. Psychiatr. Serv.
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Jackson, C. T., Allen, G., Essock, S. M., Felton, C. J., Donahue, S. A.
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Covell, N. H., Donahue, S. A., Ulaszek, W. R., Dunakin, L., Essock, S. M., Felton, C. J.
(2006). Effectiveness of Two Methods of Obtaining Feedback on Mental Health Services Provided to Anonymous Recipients. Psychiatr. Serv.
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Ahern, J., Galea, S.
(2006). Social context and depression after a disaster: the role of income inequality.. J. Epidemiol. Community Health
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Violanti, J. M., Castellano, C., O'Rourke, J., Paton, D.
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Levav, I., Novikov, I., Grinshpoon, A., Rosenblum, J., Ponizovsky, A.
(2006). Health Services Utilization in Jerusalem Under Terrorism. Am. J. Psychiatry
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Ai, A. L., Evans-Campbell, T., Santangelo, L. K., Cascio, T.
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Wu, P., Duarte, C. S., Mandell, D. J., Fan, B., Liu, X., Fuller, C. J., Musa, G., Cohen, M., Cohen, P., Hoven, C. W.
(2006). Exposure to the World Trade Center Attack and the Use of Cigarettes and Alcohol Among New York City Public High-School Students. AJPH
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Shalev, A. Y., Tuval, R., Frenkiel-Fishman, S., Hadar, H., Eth, S.
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Fraley, R. C., Fazzari, D. A., Bonanno, G. A., Dekel, S.
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Des Jarlais, D. C., Galea, S., Tracy, M., Tross, S., Vlahov, D.
(2006). Stigmatization of Newly Emerging Infectious Diseases: AIDS and SARS. AJPH
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Grieger, T. A., Waldrep, D. A., Lovasz, M. M., Ursano, R. J.
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Detsky, M. E., Sivilotti, M. L. A., Kopp, A., Austin, P. C., Juurlink, D. N.
(2005). Deliberate Self-Poisoning in Ontario Following the Terrorist Attacks of September 11, 2001. JAMA
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Vlahov, D., Galea, S.
(2005). Invited Commentary: Considering Bias in the Assessment of Respiratory Symptoms among Residents of Lower Manhattan following the Events of September 11, 2001. Am J Epidemiol
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Hagan, J. F. Jr, and the Committee on Psychosocial Aspects of Child, , and the Task Force on Terrorism,
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Galea, S., Nandi, A., Vlahov, D.
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Hoven, C. W., Duarte, C. S., Lucas, C. P., Wu, P., Mandell, D. J., Goodwin, R. D., Cohen, M., Balaban, V., Woodruff, B. A., Bin, F., Musa, G. J., Mei, L., Cantor, P. A., Aber, J. L., Cohen, P., Susser, E.
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Catalano, R., Bruckner, T., Gould, J., Eskenazi, B., Anderson, E.
(2005). Sex ratios in California following the terrorist attacks of September 11, 2001. Hum Reprod
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Azoulay, E., Pochard, F., Kentish-Barnes, N., Chevret, S., Aboab, J., Adrie, C., Annane, D., Bleichner, G., Bollaert, P. E., Darmon, M., Fassier, T., Galliot, R., Garrouste-Orgeas, M., Goulenok, C., Goldgran-Toledano, D., Hayon, J., Jourdain, M., Kaidomar, M., Laplace, C., Larche, J., Liotier, J., Papazian, L., Poisson, C., Reignier, J., Saidi, F., Schlemmer, B.
(2005). Risk of Post-traumatic Stress Symptoms in Family Members of Intensive Care Unit Patients. Am. J. Respir. Crit. Care Med.
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Reisinger, Y., Mavondo, F.
(2005). Travel Anxiety and Intentions to Travel Internationally: Implications of Travel Risk Perception. Journal of Travel Research
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Njenga, F. G., Nicholls, P. J., Nyamai, C., Kigamwa, P., Davidson, J. R. T.
(2004). Post-traumatic stress after terrorist attack: psychological reactions following the US embassy bombing in Nairobi: Naturalistic study. Br. J. Psychiatry
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Adams, M. L., Ford, J. D., Dailey, W. F.
(2004). Predictors of Help Seeking Among Connecticut Adults After September 11, 2001. AJPH
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Cabaniss, D. L., Forand, N., Roose, S. P.
(2004). Conducting Analysis After September 11: Implications for Psychoanalytic Technique. J Am Psychoanal Assoc
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(2004). Use of Psychotropic Medications Before and After Sept. 11, 2001. Am. J. Psychiatry
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Verger, P., Dab, W., Lamping, D. L., Loze, J.-Y., Deschaseaux-Voinet, C., Abenhaim, L., Rouillon, F.
(2004). The Psychological Impact of Terrorism: An Epidemiologic Study of Posttraumatic Stress Disorder and Associated Factors in Victims of the 1995-1996 Bombings in France. Am. J. Psychiatry
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Melamed, S., Shirom, A., Toker, S., Berliner, S., Shapira, I.
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Schoenfeld, F. B., Marmar, C. R., Neylan, T. C.
(2004). Current Concepts in Pharmacotherapy for Posttraumatic Stress Disorder. Psychiatr. Serv.
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Laraque, D., Boscarino, J. A., Battista, A., Fleischman, A., Casalino, M., Hu, Y.-Y., Ramos, S., Adams, R. E., Schmidt, J., Chemtob, C.
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Fairbrother, G., Stuber, J., Galea, S., Pfefferbaum, B., Fleischman, A. R.
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Siegel, C. E., Laska, E., Meisner, M.
(2004). Estimating Capacity Requirements for Mental Health Services After a Disaster Has Occurred: A Call for New Data. AJPH
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Torabi, M. R., Seo, D.-C.
(2004). National Study of Behavioral and Life Changes Since September 11. Health Educ Behav
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Boscarino, J. A., Galea, S., Adams, R. E., Ahern, J., Resnick, H., Vlahov, D.
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Catalano, R. A., Kessell, E. R., McConnell, W., Pirkle, E.
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Vlahov, D., Galea, S., Ahern, J., Resnick, H., Kilpatrick, D.
(2004). Sustained Increased Consumption of Cigarettes, Alcohol, and Marijuana Among Manhattan Residents After September 11, 2001. AJPH
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Weissman, E. M., Kushner, M., Marcus, S. M., Davis, D. F.
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Fagan, J., Galea, S., Ahern, J., Bonner, S., Vlahov, D.
(2003). Relationship of Self-Reported Asthma Severity and Urgent Health Care Utilization to Psychological Sequelae of the September 11, 2001 Terrorist Attacks on the World Trade Center Among New York City Area Residents. Psychosom. Med.
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Grieger, T. A., Fullerton, C. S., Ursano, R. J.
(2003). Posttraumatic Stress Disorder, Alcohol Use, and Perceived Safety After the Terrorist Attack on the Pentagon. Psychiatr. Serv.
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Grieger, T. A., Fullerton, C. S., Ursano, R. J., Reeves, J. J.
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Rudenstine, S., Galea, S., Ahern, J., Felton, C., Vlahov, D.
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Galea, S., Vlahov, D., Resnick, H., Ahern, J., Susser, E., Gold, J., Bucuvalas, M., Kilpatrick, D.
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Mansdorf, I. J., Weinberg, J.
(2003). Stress reactions in Israel in the face of terrorism: Two Community Samples. Traumatology
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Bleich, A., Gelkopf, M., Solomon, Z.
(2003). Exposure to Terrorism, Stress-Related Mental Health Symptoms, and Coping Behaviors Among a Nationally Representative Sample in Israel. JAMA
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Saylor, C. F., Cowart, B. L., Lipovsky, J. A., Jackson, C., Finch, A. J. Jr.
(2003). Media Exposure to September 11: Elementary School Students' Experiences and Posttraumatic Symptoms. American Behavioral Scientist
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Ford, C. A., Udry, J. R., Gleiter, K., Chantala, K.
(2003). Reactions of Young Adults to September 11, 2001. Arch Pediatr Adolesc Med
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Rosenblum, A., Joseph, H., Fong, C., Kipnis, S., Cleland, C., Portenoy, R. K.
(2003). Prevalence and Characteristics of Chronic Pain Among Chemically Dependent Patients in Methadone Maintenance and Residential Treatment Facilities. JAMA
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DeLisi, L. E., Maurizio, A., Yost, M., Papparozzi, C. F., Fulchino, C., Katz, C. L., Altesman, J., Biel, M., Lee, J., Stevens, P.
(2003). A Survey of New Yorkers After the Sept. 11, 2001, Terrorist Attacks. Am. J. Psychiatry
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Klitzman, S., Freudenberg, N.
(2003). Implications of the World Trade Center Attack for the Public Health and Health Care Infrastructures. AJPH
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Breslau, N., Davis, G. C., Schultz, L. R.
(2003). Posttraumatic Stress Disorder and the Incidence of Nicotine, Alcohol, and Other Drug Disorders in Persons Who Have Experienced Trauma. Arch Gen Psychiatry
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Pantin, H. M., Schwartz, S. J., Prado, G., Feaster, D. J., Szapocznik, J.
(2003). Posttraumatic Stress Disorder Symptoms in Hispanic Immigrants After the September 11th Attacks: Severity and Relationship to Previous Traumatic Exposure. Hispanic Journal of Behavioral Sciences
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[Abstract]