Figure 2. Two-Color Fluorescence in Situ Hybridization of Cells from Patient 2, with Schematic Representation of Chromosomes 5 and 12 Indicating the Break Points of t(5;12)(q33;p13).

Cells in interphase were probed with two flanking cosmid probes for chromosome 5, 9-4 and 4-1.⁵ More than 80 percent of cells showed one fused signal and separate red and green signals, indicating disruption of the PDGFRB gene. Arrows indicate break points.

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