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Perhaps the most compelling case to be made against investing in better cancer treatment for children in poor countries is that millions of deaths may be prevented by focusing instead on relatively inexpensive strategies for combating infectious diseases. Indeed, the World Health Organization and many international charities have committed their resources to reducing mortality from infectious diseases by two thirds during the next decade. Not surprisingly, noncommunicable diseases and chronic childhood disorders are not among the priorities of these organizations. Although the marshaling of resources to fight infectious diseases clearly has the potential to save the most children in developing countries, we would argue that alternative support mechanisms are also needed to ensure wider access to effective cancer treatment. This argument is not grounded solely in humanitarian considerations; it also addresses the rapidly changing profile of causes of illness and death among children in countries with limited resources.
Although pediatric human immunodeficiency virus infection and AIDS remain a critical health priority in sub-Saharan Africa, cancer is emerging as a major cause of childhood death in developing regions of Asia, South and Central America, northwest Africa, and the Middle East, as a result of reduced mortality from preventable infectious diseases.3 For example, in 1960, the rate of death among infants in China was 150 per 1000 live births; among children under five years of age, the death rate was 225 per 1000 live births. By 2002, the rates had decreased to 31 per 1000 and 39 per 1000, respectively. As the population of Chinese children nears 300 million, a conservative projection of 45,000 new cases of pediatric cancer each year can be made.
At the Shanghai Children's Medical Center, which serves the only Chinese city in which health insurance for catastrophic diseases is offered, 234 children with acute lymphoblastic leukemia were admitted for treatment between October 1998 and June 2003. According to Dr. J.Y. Tang of the medical center, therapy for 66 of these children (most of whom did not live in Shanghai) had to be abandoned, apparently for financial reasons, and another 52 children died of leukemia or treatment-related complications, leaving only 116 in continuous complete remission. This problem is much worse elsewhere in the country, especially in rural areas: only about 10 percent of Chinese children under 14 years of age who have acute leukemia receive protocol-based therapy, according to Dr. L.J. Gu, also of the Shanghai center.
What, if anything, can be done to bring the benefits of modern cancer treatment to more children? The most immediate and substantial results will probably come from expanded access to treatment, the elimination of reasons for abandoning treatment, and better control of complications of infections. Possible approaches to achieving these goals are admirably covered in the recent book Cancer in Developing Countries: The Great Challenge for Oncology in the 21st Century. One strategy, described in the chapters by Masera et al. and Cavalli, emphasizes a partnership ("twinning") between institutions in developed countries and those in underdeveloped countries, an approach that seems most likely to have long-term success.
Examples of the twinning approach to childhood cancer treatment have been in place in Central and South America, northwest Africa, and southeast Asia for as long as 10 years.3,4 These programs have reduced the rates of abandonment of treatment, relapse, and death due to toxic effects of treatment (see graph), and the investments they have attracted have led to improvements in access to treatment and hospital infrastructure.
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(Figure)
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Most progress in pediatric cancer treatment has been stimulated by research involving children in Western countries. Since the susceptibility to and pathogenesis of cancer are heavily influenced by genetic background, environmental exposure, and lifestyle, we must broaden research to include cases in developing countries. It will be easier to do so if the development of pediatric-cancer units in poor countries leads to the evolution of international banks of cells and tissue and of cancer registries that collect long-term follow-up data.
It has been said that if we are to preserve civilization, we must make certain its benefits are available to the many, not reserved for the few. The development of curative treatment for children with cancer is a benchmark for medical progress, and such treatment must not be sequestered within the borders of a few countries. The strategy we describe is only a start, but it could ignite a spirit of achievement that may ultimately reach even the least privileged nations.
Source Information
Dr. Ribeiro is director of the International Outreach Program and Dr. Pui is director of the Leukemia/Lymphoma Division at St. Jude Children's Research Hospital in Memphis, Tenn. Dr. Pui is also a clinical research professor at the American Cancer Society.
Cancer in Developing Countries: The Great Challenge for Oncology in the 21st Century, edited by S. Tanneberger, F. Cavalli, and F. Pannuti, was published by Zuckschwerdt, Munich, 2004.
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