Pagès et al. 353 (25): 2654, Figure 2 December 22, 2005

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Figure 2. Expression of Inflammatory Genes, Immunosuppressive Genes, and Genes Related to the Adaptive Immune Response in a Series of 75 Colorectal Cancers, According to the Presence or Absence of Any Sign of Early Metastatic Invasion and Relapse.

Early metastatic invasion was defined by the presence of vascular emboli, lymphatic invasion, and perineural invasion (collectively referred to as VELIPI), alone or in combination. Relative levels of expression of mRNA were adjusted for the level of 18S mRNA for each sample. The levels are represented as mean percentage (+SE) increases as compared with levels in the group of patients with VELIPI-positive tumors who had a relapse, and P values are for the comparison with the reference group. VEGF denotes vascular endothelial growth factor, CEACAM-1 carcinoembryonic-antigen–related cell-adhesion molecule, MMP-7 matrix metalloproteinase 7, TGF- ${beta}$ transforming growth factor ${beta}$ , T-BET T-box transcription factor 21, and IRF-1 interferon regulatory factor 1.