Demma et al. 353 (6): 587, Figure 2 August 11, 2005

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Figure 2. Immunohistochemical Staining of Skin-Biopsy and Autopsy Specimens from Patients with Rocky Mountain Spotted Fever.

Abundant spotted-fever–group rickettsiae (red area) appear in the endothelial cells of an arteriole in the dermis of Patient 4 (Panel A). Antigens and intact coccobacilli of Rickettsia rickettsii involve small vessels of the lung (Panel B), heart (Panel C), and kidney (Panel D) of Patient 7, who had a fatal case of Rocky Mountain spotted fever. (All panels were stained with hyperimmune rabbit anti–R. rickettsii antibody, alkaline phosphatase with naphthol fast-red substrate, and hematoxylin counterstain.)