Expression of Concern: Sudbø J et al. DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. N Engl J Med 2001;344:1270-8 and Sudbø J et al. The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia. N Engl J Med 2004;350:1405-13
Gregory D. Curfman, M.D., Stephen Morrissey, Ph.D., and Jeffrey M. Drazen, M.D.
In the issue of April 26, 2001, we published a study by JonSudbø et al.1 Figures 3B and 3C of that article, whichpurport to represent two different patients and stages of oralepithelial dysplasia, are in fact different magnifications ofthe same photomicrograph. Because the results of another studyby Dr. Sudbø,2 published in the issue of April 1, 2004,were derived from the same subjects followed through the samedatabase, we have similar concerns. We have informed the directorof Dr. Sudbø's institution, the Radiumhospitalet in Oslo,Norway, and await the results of his investigation.
Source Information
This editorial was published on January 20, 2006, at www.nejm.org.
References
Sudbø J, Kildal W, Risberg B, et al. DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. N Engl J Med 2001;344:1270-1278. [Free Full Text]
Sudbø J, Lippman SM, Lee JJ, et al. The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia. N Engl J Med 2004;350:1405-1413. [Free Full Text]
Curfman, G. D., Morrissey, S., Drazen, J. M.
(2006). Retraction: Sudbo J et al. DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. N Engl J Med 2001;344:1270-8 and Sudbo J et al. The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia. N Engl J Med 2004;350:1405-13. NEJM
355: 1927-1927
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Sox, H. C., Rennie, D.
(2006). Research Misconduct, Retraction, and Cleansing the Medical Literature: Lessons from the Poehlman Case. ANN INTERN MED
144: 609-613
[Abstract][Full Text]