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NEJM -- Kupsch A et al. Pallidal Deep-Brain Stimulation in Primary Generalized or Segmental Dystonia. 2006;355(19):1978-90 -- Supplementary Video

Supplement to: Kupsch A et al. Pallidal Deep-Brain Stimulation in Primary Generalized or Segmental Dystonia. N Engl J Med 2006;355(19):1978-90.



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Video 1. A 21-Year-Old Patient with Segmental Dystonia Who Had a Good Response after 6 Months of Pallidal Neurostimulation.

The average blinded rating on the movement score of the Burke–Fahn–Marsden Dystonia Rating Scale was 15.5 before surgery, 9.7 after 3 months of sham stimulation, and 4.2 after 6 months of neurostimulation.

Video 2. A 27-Year-Old Patient with Generalized Dystonia Who Had a Good Response after 3 Months of Pallidal Neurostimulation and a Sustained Benefit after 6 Months of Continuous Neurostimulation.

The average blinded rating on the movement score of the Burke–Fahn–Marsden Dystonia Rating Scale was 41.2 before surgery, 14.5 after 3 months of neurostimulation, and 16.0 after 6 months of neurostimulation.

Video 3. A 15-Year-Old Patient with Generalized Dystonia Who Had No Major Improvement after 3 Months of Sham Stimulation or after 6 Months of Continuous Neurostimulation.

This patient was among those in whom treatment was considered to have failed in this study. The average blinded rating on the movement score of the Burke–Fahn–Marsden Dystonia Rating Scale was 80.25 before surgery, 71.5 after 3 months of sham stimulation, and 77.2 after 6 months of neurostimulation.

Video 4. A 65-Year-Old Patient with Segmental Dystonia Who Had No Major Improvement after 3 Months of Sham Stimulation or after 6 Months of Continuous Neurostimulation.

This patient was among those in whom treatment was considered to have failed. The average blinded rating on the movement score of the Burke–Fahn–Marsden Dystonia Rating Scale was 8.2 points before surgery, after 3 months of sham stimulation, and after 6 months of neurostimulation. However, he had some improvement in mobile dystonia of the neck, which may not have been captured by the dystonia rating scale.
 

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