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Abstract PDF PDA Full Text PowerPoint Slide Set Editorial by Kent, D. M. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background Statins reduce the incidence of strokes among patients at increased risk for cardiovascular disease; whether they reduce the risk of stroke after a recent stroke or transient ischemic attack (TIA) remains to be established.

Methods We randomly assigned 4731 patients who had had a stroke or TIA within one to six months before study entry, had low-density lipoprotein (LDL) cholesterol levels of 100 to 190 mg per deciliter (2.6 to 4.9 mmol per liter), and had no known coronary heart disease to double-blind treatment with 80 mg of atorvastatin per day or placebo. The primary end point was a first nonfatal or fatal stroke.

Results The mean LDL cholesterol level during the trial was 73 mg per deciliter (1.9 mmol per liter) among patients receiving atorvastatin and 129 mg per deciliter (3.3 mmol per liter) among patients receiving placebo. During a median follow-up of 4.9 years, 265 patients (11.2 percent) receiving atorvastatin and 311 patients (13.1 percent) receiving placebo had a fatal or nonfatal stroke (5-year absolute reduction in risk, 2.2 percent; adjusted hazard ratio, 0.84; 95 percent confidence interval, 0.71 to 0.99; P=0.03; unadjusted P=0.05). The atorvastatin group had 218 ischemic strokes and 55 hemorrhagic strokes, whereas the placebo group had 274 ischemic strokes and 33 hemorrhagic strokes. The five-year absolute reduction in the risk of major cardiovascular events was 3.5 percent (hazard ratio, 0.80; 95 percent confidence interval, 0.69 to 0.92; P=0.002). The overall mortality rate was similar, with 216 deaths in the atorvastatin group and 211 deaths in the placebo group (P=0.98), as were the rates of serious adverse events. Elevated liver enzyme values were more common in patients taking atorvastatin.

Conclusions In patients with recent stroke or TIA and without known coronary heart disease, 80 mg of atorvastatin per day reduced the overall incidence of strokes and of cardiovascular events, despite a small increase in the incidence of hemorrhagic stroke. (ClinicalTrials.gov number, NCT00147602 [ClinicalTrials.gov] .)

Methods

The methods of the SPARCL study have been described in detail previously.¹¹ The study was approved by the local research ethics committee or institutional review board at each participating center (15 of 205 centers excluded otherwise suitable patients with an LDL cholesterol level above 160 mg per deciliter [4.1 mmol per liter], as required by their institutional review boards), and all patients gave written informed consent.

Study Hypothesis and Patient Population

The primary hypothesis of the study was that treatment with 80 mg of atorvastatin per day would reduce the risk of fatal or nonfatal stroke among patients with a history of stroke or TIA. Eligible patients were men and women over 18 years of age who had had an ischemic or hemorrhagic stroke or a TIA (diagnosed by a neurologist within 30 days after the event) 1 to 6 months before randomization. Patients with hemorrhagic stroke were included if they were deemed by the investigator to be at risk for ischemic stroke or coronary heart disease. Stroke was defined by focal clinical signs of central nervous system dysfunction of vascular origin that lasted for at least 24 hours; TIA was defined by the loss of cerebral or ocular function for less than 24 hours, presumably owing to atherosclerotic causes. Patients had to be ambulatory, with a modified Rankin score of no more than 3 (scores can range from 0 to 6, with higher scores indicating more severe disability or death), and to have an LDL cholesterol level of at least 100 mg per deciliter (2.6 mmol per liter) and no more than 190 mg per deciliter (4.9 mmol per liter).¹² The exclusion criteria, which have been described in detail previously, included atrial fibrillation, other cardiac sources of embolism, and subarachnoid hemorrhage.¹¹ Patients were enrolled between September 1998 and March 2001.

Study Protocol

Patients who were taking lipid-altering drugs had to stop these medications 30 days before the screening phase of the study. Within 30 days after the initial screening visit, eligible patients were randomly assigned to double-blind therapy with either 80 mg of atorvastatin per day or placebo. To ensure that investigators remained unaware of a patient's treatment assignment on the basis of changes in LDL cholesterol levels during the study, if LDL cholesterol levels dropped below 40 mg per deciliter (1.0 mmol per liter) in a patient treated with atorvastatin, the investigator for a randomly chosen placebo patient was notified and LDL cholesterol levels were remeasured in both patients. All patients were counseled to follow the National Cholesterol Education Program Step 1 (or similar) diet throughout the study.¹³ Follow-up visits were scheduled one, three, and six months after enrollment and every six months thereafter. Surviving patients made their last study visit between March and June 2005.

Efficacy Outcomes

The primary outcome was the time from randomization to a first nonfatal or fatal stroke. There were seven prespecified secondary composite outcomes: stroke or TIA, major coronary event (death from cardiac causes, nonfatal myocardial infarction, or resuscitation after cardiac arrest), major cardiovascular event (stroke plus any major coronary event), acute coronary event (major coronary event or unstable angina), any coronary event (acute coronary event plus a coronary revascularization procedure, unstable angina, or angina or ischemia requiring emergency hospitalization), revascularization procedure (coronary, carotid, or peripheral), and any cardiovascular event (any of the former plus clinically significant peripheral vascular disease).¹¹ Individual components of the composite end points and death from any cause were also prespecified secondary outcomes.

Safety Assessments

Full clinical laboratory assessments were performed and electrocardiograms were obtained and subsequently interpreted by a central laboratory at screening, at regular intervals during the study, and on completion of the study. Drug safety was assessed by an evaluation of the type, frequency, severity, and duration of any reported adverse event and on the basis of vital signs, physical examinations, and laboratory tests.

Statistical Analysis

The study was designed to have a statistical power of 90 percent to detect an absolute reduction of 25 percent in the primary end point in the atorvastatin group as compared with the placebo group during a median follow-up of five years with a two-sided significance level of P<0.05. Given the specified statistical power, the enrollment of 4200 patients, and an assumed annual rate of 3.5 percent for the primary end point in the placebo group, the study was designed to continue until 540 primary end points had occurred.

Seven interim analyses of efficacy were performed during the study, with a stopping boundary corresponding to a two-sided significance level of P=0.0001 for the first analysis and P=0.001 thereafter. Because of these interim analyses, the final P value had to be less than 0.048 to indicate a significant difference.

The analysis plan was prespecified and performed on an intention-to-treat basis with the inclusion of all patients who underwent randomization. Efficacy analyses were also performed according to the treatment actually received in a prespecified population consisting of a group of all randomized patients who had an entry event within six months before randomization, were compliant with the study treatment for at least six months after randomization, and did not start statin therapy that was not specified by the study until at least six months after randomization. Initially, the log-rank test was used to compare the time from randomization to the first occurrence of a particular event in the two groups. To account for baseline factors thought to be related to the risk of events, prespecified Cox proportional-hazards models were used to calculate treatment-related hazard ratios, 95 percent confidence intervals, and P values, with adjustment for geographic region, entry event (stroke or TIA), time since entry event (as a continuous variable), sex, and age at baseline (as a continuous variable). Five patients were excluded from the prespecified adjusted analyses because of missing data on the entry event (including one patient in the placebo group who had a nonfatal stroke followed by a fatal stroke). For a given composite outcome, deaths that were not included in the composite were treated as censoring events. Events that occurred after the prespecified end-of-study censoring date for each patient were not included in the analysis; inclusion of these events did not alter the inferences of the data presented. Lipid and lipoprotein levels in patients receiving treatment were determined in linear models with terms for treatment and month of measurement. The absolute reductions in risk and the numbers needed to treat were determined from five-year Kaplan–Meier rates. All P values were two-sided, with no adjustment for multiple testing.

The SPARCL steering committee developed the study protocol with the sponsor and takes responsibility for the data and data analyses. Medpace (Cincinnati) managed all data. Medpace, Charles River Laboratories Clinical Services (Brussels), and the sponsor provided site monitoring throughout the study. Two independent end-point committees (one for neurologic and one for cardiovascular end points) adjudicated all potential end points without knowledge of the patients' treatment status or cholesterol levels. A data and safety monitoring board with independent statistical support performed interim monitoring analyses for safety and efficacy.

Results

Of 6670 screened, eligible patients, 4731 (70.9 percent) fulfilled the inclusion criteria and underwent randomization (Figure 1). The median duration of follow-up was 4.9 years (range among survivors, 4.0 to 6.6). Among survivors, there was no significant difference in the number of patients in each treatment group lost to follow-up (P=0.42). More patients in the placebo group than in the atorvastatin group withdrew consent after randomization (P=0.07), permanently discontinued study treatment (20.2 percent vs. 15.4 percent of follow-up time for the primary end point, respectively; P=0.07), and began open-label, nonstudy statin therapy (7.5 percent vs. 1.0 percent of follow-up time for the primary end point, respectively; the net difference in statin use between groups was 78.1 percent). During the trial, the treatment assignment of nine patients (three assigned to atorvastatin and six assigned to placebo) was revealed to the study physician.

View larger version (30K): [in this window] [in a new window]   Figure 1. Screening, Enrollment, and Outcomes.

 
After randomization, the patients also took aspirin or other antiplatelet drugs (94.1 percent of patients in the placebo group and 93.6 percent of patients in the atorvastatin group); angiotensin-converting–enzyme inhibitors (46.8 percent and 46.9 percent, respectively); dihydropyridine derivatives (29.6 percent and 27.8 percent, respectively); beta-blockers (33.4 percent and 31.5 percent, respectively); angiotensin II–receptor antagonists (14.8 percent and 14.1 percent, respectively); vitamin K antagonists, including warfarin (12.4 percent and 12.2 percent, respectively); or open-label statins (25.4 percent and 11.4 percent, respectively). Atorvastatin was the most frequently used nonstudy, open-label statin in both study groups.

The mean (±SE) LDL cholesterol levels were similar in the two groups at baseline (Table 1). One month after randomization, the LDL cholesterol level in the atorvastatin group had decreased to 61.3±0.4 mg per deciliter (1.58±0.01 mmol per liter) (a decrease of 53 percent, P<0.001) and was unchanged in the placebo group at 133.5±0.5 mg per deciliter (3.45±0.01 mmol per liter) (P=0.65). The mean lipid values during the course of the trial were as follows: LDL cholesterol, 72.9±0.5 mg per deciliter (1.89±0.01 mmol per liter) in the atorvastatin group, as compared with 128.5±0.5 mg per deciliter (3.32±0.01 mmol per liter) in the placebo group (P<0.001); high-density lipoprotein (HDL) cholesterol, 52.1±0.3 as compared with 51.0±0.3 mg per deciliter (1.35±0.01 vs. 1.32±0.01 mmol per liter), respectively (P=0.006); total cholesterol, 147.2±0.6 as compared with 208.4±0.6 mg per deciliter (3.81±0.02 vs. 5.39±0.02 mmol per liter), (P<0.001); and triglycerides, 111.5±1.3 as compared with 145.0±1.3 mg per deciliter (1.26±0.01 vs. 1.64±0.01 mmol per liter), respectively (P<0.001).

View this table: [in this window] [in a new window]   Table 1. Baseline Characteristics of the Patients.

 
A primary end point (any nonfatal or fatal stroke) occurred in 265 patients in the atorvastatin group and 311 in the placebo group (unadjusted P=0.05) (Table 2). The absolute difference in Kaplan–Meier rates at five years was 2.2 percent (95 percent confidence interval, 0.2 to 4.2 percent). A total of 136 patients in the placebo group and 154 patients in the atorvastatin group died from causes other than stroke before they could have a nonfatal stroke. After prespecified adjustment for baseline factors, atorvastatin was associated with a 16.0 percent relative reduction in the risk of nonfatal or fatal stroke (hazard ratio, 0.84; 95 percent confidence interval, 0.71 to 0.99; P=0.03) (Table 2 and Figure 2). Prespecified analysis of 4162 patients according to the protocol showed an 18.0 percent relative reduction in the risk of stroke in the atorvastatin group, as compared with the placebo group (hazard ratio, 0.82; 95 percent confidence interval, 0.69 to 0.98; P=0.03).

View this table: [in this window] [in a new window]   Table 2. Estimates of the Hazard Ratio for the Primary and Secondary Efficacy Outcome Measures.

 

View larger version (33K): [in this window] [in a new window]   Figure 2. Kaplan–Meier Curves for Stroke and TIA. Results are shown on an intention-to-treat basis with prespecified adjustments for geographic region, entry event (stroke or TIA), time since entry event, sex, and baseline age for the first occurrence of a fatal or nonfatal stroke (Panel A), fatal stroke (Panel B), nonfatal stroke (Panel C), and stroke or TIA (Panel D). HR denotes hazard ratio, and CI confidence interval.

 
Analysis of secondary end points showed reductions in the combined risk of stroke and TIA. The risk of cardiovascular events, including major coronary events and revascularization procedures, was reduced substantially (Table 2). There was no significant difference between treatment groups in overall mortality (including cancer-related mortality). Kaplan–Meier estimates for selected components of the secondary end points are given in Figure 3.

View larger version (33K): [in this window] [in a new window]   Figure 3. Kaplan–Meier Curves for Coronary and Cardiovascular Events. Results are shown on an intention-to-treat basis with prespecified adjustments for geographic region, entry event (stroke or TIA), time since entry event, sex, and baseline age for the first occurrence of any coronary event (acute coronary event plus coronary revasculariza-tion procedure, unstable angina, or angina or ischemia requiring emergency hospitalization) (Panel A), any major coronary event (death from cardiac causes, nonfatal myocardial infarction, resuscitation after cardiac arrest) (Panel B), any major cardiovascular event (primary event plus any major coronary event) (Panel C), and any cardiovascular event (any of the former plus clinically significant peripheral vascular disease) (Panel D). HR denotes hazard ratio, and CI confidence interval.

 
Post hoc analyses indicated significant differences in the treatment effect (hazard ratios) based on the type of stroke occurring during the trial (ischemic, hemorrhagic, or unclassified stroke) when the other types were treated as censoring events (P=0.01 by the likelihood-ratio test). The cause-specific adjusted hazard ratios in the atorvastatin group, as compared with the placebo group, were 0.78 (95 percent confidence interval, 0.66 to 0.94) for ischemic stroke, 1.66 (95 percent confidence interval, 1.08 to 2.55) for hemorrhagic stroke, and 0.55 (95 percent confidence interval, 0.21 to 1.40) for unclassified stroke. Of the 492 patients who had at least one ischemic stroke, 218 were in the atorvastatin group and 274 were in the placebo group; of the 88 patients who had at least one hemorrhagic stroke, 55 were in the atorvastatin group and 33 were in the placebo group; and of the 19 patients who had at least one unclassified stroke, 7 were in the atorvastatin group and 12 were in the placebo group. The incidence of fatal hemorrhagic stroke did not differ significantly between the groups (17 in the atorvastatin and 18 in the placebo group).

Safety assessments revealed no significant differences between groups in the incidence of serious adverse events (Table 3). There were five cases of rhabdomyolysis, two in the atorvastatin group and three in the placebo group. Persistent elevation of alanine or aspartate aminotransferase (>3 times the upper limit of the normal group on two consecutive occasions) was more frequent in the atorvastatin group (51 patients, or 2.2 percent) than in the placebo group (11 patients, or 0.5 percent; P<0.001 by the chi-square test). There were no cases of liver failure.

View this table: [in this window] [in a new window]   Table 3. Incidence of Adverse Events and Elevated Laboratory Values.

 
Discussion

This prospective, randomized, placebo-controlled trial demonstrated that treatment with 80 mg of atorvastatin per day reduced the risk of subsequent stroke in patients without known coronary heart disease and with LDL cholesterol levels of 100 to 190 mg per deciliter who had had a recent stroke or TIA. The study was not powered to assess the effect of treatment on the risk of death from any cause or on fatal and nonfatal stroke separately, but the risk of fatal stroke was significantly reduced. The reduction in the risk of nonfatal stroke was consistent with the treatment effect, but not significant.

Although at enrollment, patients had no known coronary heart disease, the risk of cardiovascular events, including major coronary events and revascularization procedures, was also substantially reduced. On the basis of our data, 46 patients (95 percent confidence interval, 24 to 243) would need to be treated for five years to prevent one stroke, 29 patients (95 percent confidence interval, 18 to 75) to prevent one major cardiovascular event, and 32 patients (95 percent confidence interval, 22 to 59) to avoid one revascularization procedure. These benefits were observed despite the increased use of open-label nonstudy statins during the study, a result suggesting that the effect is robust.

As expected, the beneficial effect of statin therapy on the risk of recurrent stroke was due to a reduction in the risk of cerebral infarction, the mechanism of which largely has been attributed to a reduction in LDL cholesterol levels.⁸ The lower average LDL cholesterol level achieved in the atorvastatin as compared with the placebo group is consistent with this hypothesis. Other putative mechanisms include a variety of possible pleiotropic effects.¹⁴

Our results contrast with those of the Heart Protection Study (HPS), which found no reduction in the risk of stroke among patients with prior cerebrovascular disease (10.4 percent of patients in the statin group had a recurrent stroke, as compared with 10.5 percent of patients in the placebo group).¹⁰ A possible explanation for this difference in results is that patients in the HPS were enrolled an average of 4.3 years after the index event, whereas the risk of recurrence is highest within the first years after stroke.^10,15,16 Another explanation may be the larger reduction in LDL cholesterol in our study than in the HPS (56 mg per deciliter [1.4 mmol per liter] vs. 39 mg per deciliter [1.0 mmol per liter]).¹⁰ Other differences between the trials have been reviewed previously.⁹

Although patients with known coronary heart disease were excluded at baseline, 9.2 percent (434 patients) had a coronary event or a noncoronary revascularization procedure during the trial. Treatment with atorvastatin reduced the risk of these events. This observation adds to evidence from previous studies involving patients at increased risk for cardiovascular disease showing that statin treatment reduces atherosclerotic complications.^2,3,4,5,6,7 Our results support the concept that from the standpoint of statin treatment, stroke or TIA should be considered a coronary heart disease risk equivalent.

In our study, the overall benefit in terms of the reduction in the risk of stroke was significant despite an increase in hemorrhagic stroke in the atorvastatin group. Statistical heterogeneity was observed in the effects of atorvastatin on ischemic and hemorrhagic stroke. An increase in the incidence of hemorrhagic stroke among patients with cerebrovascular disease treated with simvastatin (40 mg) was noted in the HPS.¹⁰ Epidemiologic studies have suggested an association between low cholesterol levels and brain hemorrhage.^17,18,19 Statin trials conducted largely in patients without cerebrovascular disease have reduced LDL cholesterol levels to 70 mg per deciliter (1.8 mmol per liter) or below, with no increase in the incidence of hemorrhagic stroke.^20,21,22 The small number of patients with brain hemorrhage at entry in our study precludes any meaningful conclusions regarding the relative risks and benefits of statin treatment in this population. The potential risk of recurrent hemorrhage should be considered when one is deciding whether to administer a statin to patients who have had a hemorrhagic stroke.

In conclusion, in patients with a recent stroke or TIA, treatment with 80 mg of atorvastatin per day decreased the risk of stroke, major coronary events, and revascularization procedures. These results support the initiation of atorvastatin treatment soon after a stroke or TIA.

Supported by Pfizer.

Dr. Amarenco reports having received consulting fees from AstraZeneca, Novartis, Pfizer, and Sanofi-Aventis; lecture fees from Otsuka Pharmaceutical and Pfizer; and grant support from Pfizer. Dr. Bogousslavsky reports having received consulting fees from Pfizer and grant support from Pfizer. Dr. Callahan reports having received consulting fees from Sanofi, lecture fees from Bristol-Myers Squibb and Sanofi, and grant support from Pfizer. Dr. Goldstein reports having received consulting fees from Pfizer, Bayer, AstraZeneca, Bristol-Myers Squibb/Sanofi, GlaxoSmithKline, Merck Research Laboratories, Johnson & Johnson Cordis, and Organon; lecture fees from Bayer; and grant support from AGA Medical, Boehringer Ingelheim, the National Institutes of Health, Pfizer, and the Department of Veterans Affairs. Dr. Hennerici reports having received grant support from Pfizer and Servier. Dr. Rudolph is an employee of Pfizer and reports owning stock in the company. Dr. Sillesen reports having received consulting fees from Sanofi-Aventis; lecture fees from AstraZeneca, Bristol-Myers Squibb, Merck, and Sanofi-Aventis; and grant support from Pfizer. Ms. Simunovic and Mr. Szarek are employees of Pfizer and report owning stock in the company. Dr. Welch reports having received consulting fees from Eisai, GlaxoSmithKline, Medpointe, AstraZeneca, NMT Medical, and Ortho-McNeil; lecture fees from GlaxoSmithKline; and grant support from Pfizer. Dr. Zivin reports having received consulting fees from Angel Pharmaceuticals, MEDACorp, MEDIACorp, Pfizer, and Sirex; and grant support from PhotoThera and Pfizer. No other potential conflict of interest relevant to this article was reported.

We are indebted to all the trial participants and the vast numbers of doctors, nurses, and hospital staff across the globe for their long-term commitment to the study; to Ellen Huang for her dedication and support; and to Sheila Auster, Sandra Brown, Marlen Castano, Lana De Weaver, Karen Ivanac, Sinde Krapf, Jaman Maroni, Scott McBride, James Nawrocki, Connie Newman, Lekan Odeleye, Bill Sasiela, Robert Sawyer, Heike Schwende, John Tsai, and Bernd Wagner (all at Pfizer) for their contributions.

^* Other members of the SPARCL Study are listed in the Appendix.

Source Information

Pierre Amarenco, M.D. (Denis Diderot University, Paris), Julien Bogousslavsky, M.D. (University of Lausanne, Lausanne, Switzerland), Alfred Callahan, III, M.D. (Neurologic Consultants, Nashville), Larry B. Goldstein, M.D. (Duke University Medical Center, Durham, N.C.), Michael Hennerici, M.D., Ph.D. (Universitat Heidelberg, Mannheim, Germany), Amy E. Rudolph, Ph.D. (Pfizer, New York), Henrik Sillesen, M.D., D.M.Sc. (University of Copenhagen, Copenhagen), Lisa Simunovic, M.S. (Pfizer, New York), Michael Szarek, M.S. (Pfizer, New York), K.M.A. Welch, M.B., Ch.B., (Rosalind Franklin University of Medicine and Science, North Chicago), and Justin A. Zivin, M.D., Ph.D. (University of California, San Diego) assume full responsibility for the overall content and integrity of the article.

Address reprint requests to Dr. Welch at the Rosalind Franklin University of Medicine and Science, 3333 Green Bay Rd., North Chicago, IL 60064, or at michael.welch{at}rosalindfranklin.edu.

References

1. Sacco RL, Adams R, Albers G, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Stroke 2006;37:577-617. [Free Full Text]
2. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344:1383-1389. [CrossRef][Web of Science][Medline]
3. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998;339:1349-1357. [Free Full Text]
4. Plehn JF, Davis BR, Sacks FM, et al. Reduction of stroke incidence after myocardial infarction with pravastatin: the Cholesterol and Recurrent Events (CARE) study. Circulation 1999;99:216-223. [Free Full Text]
5. Sever PS, Dahlof B, Poulter NR, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial -- Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003;361:1149-1158. [CrossRef][Web of Science][Medline]
6. Colhoun HM, Betteridge DJ, Durrington PN, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 2004;364:685-696. [CrossRef][Web of Science][Medline]
7. Heart Protection Collaborative Study Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002;360:7-22. [CrossRef][Web of Science][Medline]
8. Amarenco P, Labreuche J, Lavallée P, Touboul P-J. Statins in stroke prevention and carotid atherosclerosis: systematic review and meta-analysis. Stroke 2004;35:2902-2909. [Free Full Text]
9. Goldstein LB, Amarenco P, Bogousslavsky J, et al. Statins for secondary stroke prevention in patients without known coronary heart disease: the jury is still out. Cerebrovasc Dis 2004;18:1-2. [Web of Science][Medline]
10. Heart Protection Collaborative Study Group. Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20,536 people with cerebrovascular disease or other high-risk conditions. Lancet 2004;363:757-767. [CrossRef][Web of Science][Medline]
11. Amarenco P, Bogousslavsky J, Callahan AS, et al. Design and baseline characteristics of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study. Cerebrovasc Dis 2003;16:389-395. [Erratum, Cerebrovasc Dis 2004;17:91-2.] [CrossRef][Web of Science][Medline]
12. Rankin J. Cerebral vascular accidents in patients over the age of 60. II. Prognosis. Scott Med J 1957;2:200-215. [Medline]
13. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497. [Free Full Text]
14. Amarenco P, Lavallée PC, Touboul P-J. Stroke prevention, blood cholesterol, and statins. Lancet Neurol 2004;3:271-278. [CrossRef][Web of Science][Medline]
15. Vickrey BG, Rector TS, Wickstrom SL, et al. Occurrence of secondary ischemic events among persons with atherosclerotic vascular disease. Stroke 2002;33:901-906. [Free Full Text]
16. Hardie K, Hankey GJ, Jamrozik K, Broadhurst RJ, Anderson C. Ten-year risk of first recurrent stroke and disability after first-ever stroke in the Perth Community Stroke Study. Stroke 2004;35:731-735. [Free Full Text]
17. Iso H, Jacobs DR Jr, Wentworth D, Neaton JD, Cohen JD. Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the Multiple Risk Factor Intervention Trial. N Engl J Med 1989;320:904-910. [Abstract]
18. Yano K, Reed DM, MacLean CJ. Serum cholesterol and hemorrhagic stroke in the Honolulu Heart Program. Stroke 1989;20:1460-1465. [Free Full Text]
19. Lee S-H, Bae H-J, Yoon B-W, Kim H, Kim D-E, Roh J-K. Low concentration of serum total cholesterol is associated with multifocal signal loss lesions on gradient-echo magnetic resonance imaging: analysis of risk factors for multifocal signal loss lesions. Stroke 2002;33:2845-2849. [Free Full Text]
20. Wiviott SD, Cannon CP, Morrow DA, et al. Can low-density lipoprotein be too low? The safety and efficacy of achieving very low low-density lipoprotein with intensive statin therapy: a PROVE IT-TIMI 22 substudy. J Am Coll Cardiol 2005;46:1411-1416. [Erratum, J Am Coll Cardiol 2006;47:472.] [Free Full Text]
21. Waters DD, Schwartz GG, Olsson AG, et al. Effects of atorvastatin on stroke in patients with unstable angina or non-Q-wave myocardial infarction: a Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) substudy. Circulation 2002;106:1690-1695. [Free Full Text]
22. Waters DD, LaRosa JC, Barter P, et al. Effects of intensive lipid lowering with atorvastatin on cerebrovascular events in patients with stable coronary disease: a Treating to New Targets (TNT) substudy. Circulation 2005;112:Suppl 1:2020-2020. 

Participants in the SPARCL Study were as follows: Steering Committee — K.M.A. Welch (chair), A. Callahan, III, L.B. Goldstein, J. Zivin, United States; P. Amarenco, France; J. Bogousslavsky, Switzerland; M.G. Hennerici, Germany; H. Sillesen, Denmark; Publication Subcommittee — H. Sillesen, Denmark (chair); W. Clark, L.B. Goldstein, J. Zivin, United States; A. Dávalos, Spain; M. Kaste, Finland; L. Leiter, Canada; Retention Subcommittee — P. Amarenco (cochair), France; A. Callahan III (cochair), I. Altafullah, G. Graham, United States; J. Glahn, Germany; D. Jiménez Hernández, Spain; R. MacWalter, United Kingdom; R. Scott, New Zealand; A. Shuaib, Canada; J. Sivenius, Finland; R. Stipal, Czech Republic; Safety Committee — R. Hart (chair), J. Marsh, R. Sacco, United States; B. Norrving, Sweden; S. Pocock, United Kingdom; Cerebrovascular End-Point Committee — J. Easton (chair), J. Whisnant, United States; M. Brown, United Kingdom; Z. Nagy, Hungary; Cardiovascular End-Point Committee — B. O'Neill (chair), Canada; F. Kleber, Germany; J.-M. LaBlanche, France; F. Welty, United States; Investigators (number of randomized patients in parentheses) — Australia (167): D. Crimmins, S. Davis, S. Dimmitt, G. Donnan, J. Frayne, D. Freilich, A. Zagami; Austria (87): J. Mikocki, C. Schmidauer, R. Schmidt; Belgium (41): J. De Bleecker, F. Deceuninck, P. Tack, V. Thijs; Brazil (8): J. Gomes Fernandes; Canada (295): M. Beaudry, R. Cote, K. Hoyte, L.-H. Lebrun, A. Mackey, D. Sahlas, D. Selchen, A. Shuaib, J.D. Spence, P. Teal, M. Winger; Chile (10): G. Matamala; Czech Republic (222): R. Cifkova, Z. Kalita, I. Rektor, H. Rosolova, R. Stipal, D. Vaclavik; Denmark (57): G. Boysen, H. Iversen, H. Klingenberg, H. Sillesen; Finland (385): M. Hillbom, M. Kaste, H. Numminen, A. Pilke, A. Salmivaara, J. Sivenius; France (161): S. Alamowitch, P. Amarenco, J. Boulliat, T. De Broucker, F. Chollet, M.-H. Mahagne, L. Milandre, T. Moulin; Germany (284): U. Bogdahn, H.-C. Diener, M. Dichgans, J. Glahn, R. Haberl, L. Harms, M.G. Hennerici, S. Knecht, G. Kroczek, C. Lichy, D. Sander, D. Schneider; Greece (39): C. Karageorgiou, A. Kazis, I. Milonas, P. Stathis, D. Vogiatzoglou; Israel (61): N. Bornstein, S. Honigman, Y. Lampl, J. Streifler; Italy (75): A. Capurso, G. Comi, C. Ferrarese, C. Gandolfo, M. Poloni, U. Senin; Mexico (9): R. Rangel Guerra; Netherlands (171): A.M. Boon, J.H.A. De Keyser, P.L.M. De Kort, J.A. Haas, D.J. Kamphuis, P.-J. Koudstaal; New Zealand (219): N. Anderson, R. Scott, G. Singh; Poland (249): A. Czlonkowska, W. Drozdowski, Z. Gralewski, W. Kozubski, A. Kuczynska-Zardzewialy, R. Podemski, Z. Stelmasiak, A. Szczudlik; Portugal (102): C. Da Costa Correia, J. Ferro, L. Salgueiro e Cunha; Slovakia (37): J. Lietava, K. Raslova; South Africa (93): J. Carr, J. Gardiner, A. Kruger; Spain (744): J. Alvarez-Sabin, A. Chamorro, E. Diez-Tejedor, O. Fernández, J. Trejo Gabriel y Galán, J. González Marcos, J. Egido Herrero, M. Jiménez Martínez, A. Lago Martin, E. Mostacero Miguel, J. Vivancos Mora, J. Moltó, J. Viguera Romero, E. Cuartero Rodriguez, F. Rubio, J. Serena; Sweden (121): A.C. Laska, B. Leijd, T. Strand, A. Terent, A. Waegner, T. Wallén; Switzerland (86): R. Baumgartner, J. Bogousslavsky, H. Hungerbühler, P. Lyrer, H. Mattle; United Kingdom (146): P.M. Bath, E.B. Ekpo, A. Freeman, K.R. Lees, M.J. MacLeod, R.S. MacWalter, A.K. Sharma, H.G.M. Shetty; United States (853): G. Albers, I. Altafullah, O. Benavente, D. Book, J. Broderick, C. Calder, A. Callahan III, W. Carlini, S. Chaturvedi, T. Chippendale, W. Clark, B. Coull, P. Davis, T. Devlin, A. Dick, G. Dooneief, R. Duff, N. Estronza, A. Forteza, M. Frankel, J. Frey, G. Friday, J. Goldstein, G. Graham, M. Hammer, W. Harper, J. Harris, B. Hendin, D. Hess, R. Hinton, J. Hollander, R. Hughes, S. Kasner, T. Kent, L. Kim, H. Kirshner, M. LaMonte, L. Ledbetter, P. Lee-Kwen, K. Levin, R. Libman, J. Matlock, P. McDowell, F. McGee Jr., B. Meyer, A. Minagar, M. Moussouttas, R. Munson, M. Nash, A. Nassief, S. Orr, G. Ratinov, V. Salanga, S. Silliman, R. Singer, D. Smith, H. Sullivan, G. Tietjen, D. Thaler, M. Tuchman, D. Uskavitch, P. Verro, R. Vicari, R. Weinstein, J. Wilterdink, R. Zweifler; Venezuela (9): M. De Bastos.

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Statin Therapy after Stroke or Transient Ischemic Attack
Cohen J. S., East J. E., Elkind M. S.V., Khan N. A., Mascitelli L., Pezzetta F., Welch K.M.A., the SPARCL Investigators , Kent D.
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N Engl J Med 2006; 355:2368-2371, Nov 30, 2006. Correspondence

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• Coutts, S. B., Hill, M. D., Campos, C. R., Choi, Y. B., Subramaniam, S., Kosior, J. C., Demchuk, A. M., for the VISION study group, (2008). Recurrent Events in Transient Ischemic Attack and Minor Stroke: What Events Are Happening and to Which Patients?. Stroke 39: 2461-2466 [Abstract] [Full Text]  
• Goldstein, L. B., Amarenco, P., LaMonte, M., Gilbert, S., Messig, M., Callahan, A., Hennerici, M., Sillesen, H., Welch, K. M. A., on behalf of the SPARCL Investigators, (2008). Relative Effects of Statin Therapy on Stroke and Cardiovascular Events in Men and Women: Secondary Analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study. Stroke 39: 2444-2448 [Abstract] [Full Text]  
• Romero, J. R., Morris, J., Pikula, A. (2008). Review: Stroke prevention: modifying risk factors. Ther Adv Cardiovasc Dis 2: 287-303 [Abstract]  
• O'Keefe, J. H., Bybee, K. A., Lavie, C. J. (2008). Intensive Lipid Intervention in the Post-ENHANCE Era. Mayo Clin Proc. 83: 867-869 [Full Text]  
• Caplan, L. R. (2008). A 70-Year-Old Man With a Transient Ischemic Attack: Review of Internal Carotid Artery Stenosis. JAMA 300: 81-90 [Abstract] [Full Text]  
• Amarenco, P., Steg, P. G. (2008). Stroke is a coronary heart disease risk equivalent: implications for future clinical trials in secondary stroke prevention. Eur Heart J 29: 1605-1607 [Full Text]  
• FitzMaurice, E., Wendell, L., Snider, R., Schwab, K., Chanderraj, R., Kinnecom, C., Nandigam, K., Rost, N. S., Viswanathan, A., Rosand, J., Greenberg, S. M., Smith, E. E. (2008). Effect of Statins on Intracerebral Hemorrhage Outcome and Recurrence. Stroke 39: 2151-2154 [Abstract] [Full Text]  
• Tanaka, K., Ishikawa, Y., Yokoyama, M., Origasa, H., Matsuzaki, M., Saito, Y., Matsuzawa, Y., Sasaki, J., Oikawa, S., Hishida, H., Itakura, H., Kita, T., Kitabatake, A., Nakaya, N., Sakata, T., Shimada, K., Shirato, K., for the JELIS Investigators, Japan, (2008). Reduction in the Recurrence of Stroke by Eicosapentaenoic Acid for Hypercholesterolemic Patients: Subanalysis of the JELIS Trial. Stroke 39: 2052-2058 [Abstract] [Full Text]  
• Squizzato, A., Dentali, F., Romualdi, E., Ageno, W. (2008). Statins and Secondary Prevention of Ischemic and Hemorrhagic Stroke. Stroke 39: e113-e113 [Full Text]  
• Tinetti, M. E. (2008). Over-the-Counter Sales of Statins and Other Drugs for Asymptomatic Conditions. NEJM 358: 2728-2732 [Full Text]  
• Jacobs, B. S., Greenberg, S. M. (2008). Statins, low cholesterol, and hemorrhagic stroke: An uncertain triangle. Neurology 70: 2355-2356 [Full Text]  
• Goldstein, L. B., Amarenco, P., Szarek, M., Callahan, A. III, Hennerici, M., Sillesen, H., Zivin, J. A., Welch, K.M.A., On behalf of the SPARCL Investigators, (2008). Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study. Neurology 70: 2364-2370 [Abstract] [Full Text]  
• Rodriguez-Yanez, M., Agulla, J., Rodriguez-Gonzalez, R., Sobrino, T., Castillo, J. (2008). Review: Statins and stroke. Ther Adv Cardiovasc Dis 2: 157-166 [Abstract]  
• Sudlow, C (2008). Preventing further vascular events after a stroke or transient ischaemic attack: an update on medical management. PN 8: 141-157 [Abstract] [Full Text]  
• Shah, S. J., Waters, D. D., Barter, P., Kastelein, J. J.P., Shepherd, J., Wenger, N. K., DeMicco, D. A., Breazna, A., LaRosa, J. C. (2008). Intensive Lipid-Lowering With Atorvastatin for Secondary Prevention in Patients After Coronary Artery Bypass Surgery. J Am Coll Cardiol 51: 1938-1943 [Abstract] [Full Text]  
• Mascitelli, L., Pezzetta, F., Castillo, J., Blanco, M., Davalos, A., de Compostela, S. (2008). STATIN TREATMENT WITHDRAWAL IN ISCHEMIC STROKE: A CONTROLLED RANDOMIZED STUDY. Neurology 70: 1720-1721 [Full Text]  
• Arvanitakis, Z., Schneider, J. A., Wilson, R. S., Bienias, J. L., Kelly, J. F., Evans, D. A., Bennett, D. A. (2008). Statins, incident Alzheimer disease, change in cognitive function, and neuropathology. Neurology 70: 1795-1802 [Abstract] [Full Text]  
• Fedoruk, L. M., Wang, H., Conaway, M. R., Kron, I. L., Johnston, K. C. (2008). Statin Therapy Improves Outcomes After Valvular Heart Surgery. Ann. Thorac. Surg. 85: 1521-1526 [Abstract] [Full Text]  
• Adams, R. J., Albers, G., Alberts, M. J., Benavente, O., Furie, K., Goldstein, L. B., Gorelick, P., Halperin, J., Harbaugh, R., Johnston, S. C., Katzan, I., Kelly-Hayes, M., Kenton, E. J., Marks, M., Sacco, R. L., Schwamm, L. H. (2008). Update to the AHA/ASA Recommendations for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack. Stroke 39: 1647-1652 [Full Text]  
• Golomb, B. A., Dimsdale, J. E., White, H. L., Ritchie, J. B., Criqui, M. H. (2008). Reduction in Blood Pressure With Statins: Results From the UCSD Statin Study, a Randomized Trial. Arch Intern Med 168: 721-727 [Abstract] [Full Text]  
• Betteridge, D. J., DeFronzo, R. A., Chilton, R. J. (2008). PROactive: time for a critical appraisal. Eur Heart J 29: 969-983 [Abstract] [Full Text]  
• Vernooij, M. W., van der Lugt, A., Ikram, M. A., Wielopolski, P. A., Niessen, W. J., Hofman, A., Krestin, G. P., Breteler, M.M.B. (2008). Prevalence and risk factors of cerebral microbleeds: The Rotterdam Scan Study. Neurology 70: 1208-1214 [Abstract] [Full Text]  
• Levy, E. I., Mocco, J., Samuelson, R. M., Ecker, R. D., Jahromi, B. S., Hopkins, L. N. (2008). Optimal treatment of carotid artery disease.. J Am Coll Cardiol 51: 979-985 [Abstract] [Full Text]  
• Nassief, A., Marsh, J. D. (2008). Statin Therapy for Stroke Prevention. Stroke 39: 1042-1048 [Abstract] [Full Text]  
• Mascitelli, L., Vos, E. (2008). Analyzing the Results of the Treating to New Targets Study. ANN INTERN MED 148: 321-322 [Full Text]  
• Vergouwen, M. D.I., de Haan, R. J., Vermeulen, M., Roos, Y. B.W.E.M. (2008). Statin Treatment and the Occurrence of Hemorrhagic Stroke in Patients With a History of Cerebrovascular Disease. Stroke 39: 497-502 [Abstract] [Full Text]  
• Kinlay, S., Schwartz, G. G., Olsson, A. G., Rifai, N., Szarek, M., Waters, D. D., Libby, P., Ganz, P., for the Myocardial Ischemia Reduction with Aggress, (2008). Inflammation, Statin Therapy, and Risk of Stroke After an Acute Coronary Syndrome in the MIRACL Study. Arterioscler. Thromb. Vasc. Bio. 28: 142-147 [Abstract] [Full Text]  
• (2007). Correction: Update in General Internal Medicine. ANN INTERN MED 147: 818-818 [Full Text]  
• Arboix, A, Font, A, Garro, C, Garcia-Eroles, L, Comes, E, Massons, J (2007). Recurrent lacunar infarction following a previous lacunar stroke: a clinical study of 122 patients. J. Neurol. Neurosurg. Psychiatry 78: 1392-1394 [Abstract] [Full Text]  
• Air, E. L., Kissela, B. M. (2007). Diabetes, the Metabolic Syndrome, and Ischemic Stroke: Epidemiology and possible mechanisms. Diabetes Care 30: 3131-3140 [Full Text]  
• Amarenco, P., Goldstein, L. B., Szarek, M., Sillesen, H., Rudolph, A. E., Callahan, A. III, Hennerici, M., Simunovic, L., Zivin, J. A., Welch, K. M. A., on behalf of the SPARCL Investigators, (2007). Effects of Intense Low-Density Lipoprotein Cholesterol Reduction in Patients With Stroke or Transient Ischemic Attack: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial. Stroke 38: 3198-3204 [Abstract] [Full Text]  
• Henyan, N. N, Riche, D. M, East, H. E, Gann, P. N (2007). Impact of Statins on Risk of Stroke: A Meta-Analysis. The Annals of Pharmacotherapy 41: 1937-1945 [Abstract] [Full Text]  
• Chaturvedi, S., Turan, T. N., Lynn, M. J., Kasner, S. E., Romano, J., Cotsonis, G., Frankel, M., Chimowitz, M. I., For the WASID Study Group, (2007). Risk factor status and vascular events in patients with symptomatic intracranial stenosis. Neurology 69: 2063-2068 [Abstract] [Full Text]  
• Zhang, L., Zhang, Z. G., Liu, X. S., Hozeska-Solgot, A., Chopp, M. (2007). The PI3K/Akt Pathway Mediates the Neuroprotective Effect of Atorvastatin in Extending Thrombolytic Therapy After Embolic Stroke in the Rat. Arterioscler. Thromb. Vasc. Bio. 27: 2470-2475 [Abstract] [Full Text]  
• Vos, E., de Groot, P., Goldstein, L. (2007). Low LDL cholesterol, statins, and brain hemorrhage: Should we worry?. Neurology 69: 1469-1470 [Full Text]  
• Samuelson, R. M., Yamamoto, J., Levy, E. I., Siddiqui, A. H., Hopkins, L. N. (2007). The Argument to Support Broader Application of Extracranial Carotid Artery Stent Technology. Circulation 116: 1602-1610 [Full Text]  
• Touze, E., Varenne, O., Mas, J.-L. (2007). Overestimation of Coronary Risk in Stroke Patients. Stroke 38: e98-e98 [Full Text]  
• Colivicchi, F., Bassi, A., Santini, M., Caltagirone, C. (2007). Discontinuation of Statin Therapy and Clinical Outcome After Ischemic Stroke. Stroke 38: 2652-2657 [Abstract] [Full Text]  
• Sturgeon, J. D., Folsom, A. R., Longstreth, W.T. Jr, Shahar, E., Rosamond, W. D., Cushman, M. (2007). Risk Factors for Intracerebral Hemorrhage in a Pooled Prospective Study. Stroke 38: 2718-2725 [Abstract] [Full Text]  
• Gueyffier, F., Bejan-Angoulvant, T. (2007). Do We Need to Assess the Effect of Treatment Withdrawal?: The Paradigm of Life-Long Prevention. Stroke 38: 2629-2630 [Full Text]  
• Mascitelli, L., Pezzetta, F., Goldstein, L. B. (2007). LOW LDL CHOLESTEROL, STATINS, AND BRAIN HEMORRHAGE: SHOULD WE WORRY?. Neurology 69: 1061-1062 [Full Text]  
• Benn, M., Nordestgaard, B. G., Jensen, J. S., Tybjaerg-Hansen, A. (2007). Polymorphisms in Apolipoprotein B and Risk of Ischemic Stroke. J. Clin. Endocrinol. Metab. 92: 3611-3617 [Abstract] [Full Text]  
• Mohler, E. R III (2007). Carotid stenting for atherothrombosis. Heart 93: 1147-1151 [Full Text]  
• Blanco, M., Nombela, F., Castellanos, M., Rodriguez-Yanez, M., Garcia-Gil, M., Leira, R., Lizasoain, I., Serena, J., Vivancos, J., Moro, M. A., Davalos, A., Castillo, J. (2007). Statin treatment withdrawal in ischemic stroke: A controlled randomized study. Neurology 69: 904-910 [Abstract] [Full Text]  
• Shojania, K. G., Sampson, M., Ansari, M. T., Ji, J., Doucette, S., Moher, D. (2007). How Quickly Do Systematic Reviews Go Out of Date? A Survival Analysis. ANN INTERN MED 147: 224-233 [Abstract] [Full Text]  
• LaRosa, J. C. (2007). Means and Ends of Statins and Low-Density Lipoprotein Cholesterol Lowering. J Am Coll Cardiol 50: 419-420 [Full Text]  
• Harrington, D. W., Munekata, M. T. (2007). Update in General Internal Medicine. ANN INTERN MED 147: 104-116 [Full Text]  
• Rundek, T. (2007). Do Women Have Worse Outcome After Stroke Caused by Intracranial Arterial Stenosis?. Stroke 38: 2025-2027 [Full Text]  
• Ovbiagele, B., Saver, J. L., Starkman, S., Kim, D., Ali, L. K., Jahan, R., Duckwiler, G. R., Vinuela, F., Pineda, S., Liebeskind, D. S. (2007). Statin enhancement of collateralization in acute stroke. Neurology 68: 2129-2131 [Abstract] [Full Text]  
• Authors/Task Force Members:, , Mancia, G., De Backer, G., Dominiczak, A., Cifkova, R., Fagard, R., Germano, G., Grassi, G., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., Narkiewicz, K., Ruilope, L., Rynkiewicz, A., Schmieder, R. E., Struijker Boudier, H. A.J., Zanchetti, A., ESC Committee for Practice Guidelines (CPG):, , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Filippatos, G., Funck-Brentano, C., Hellemans, I., Kristensen, S. D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J. L., ESH Scientific Council:, , Kjeldsen, S. E., Erdine, S., Narkiewicz, K., Kiowski, W., Agabiti-Rosei, E., Ambrosioni, E., Cifkova, R., Dominiczak, A., Fagard, R., Heagerty, A. M., Laurent, S., Lindholm, L. H., Mancia, G., Manolis, A., Nilsson, P. M., Redon, J., Schmieder, R. E., Struijker-Boudier, H. A.J., Viigimaa, M., Document Reviewers:, , Filippatos, G., Adamopoulos, S., Agabiti-Rosei, E., Ambrosioni, E., Bertomeu, V., Clement, D., Erdine, S., Farsang, C., Gaita, D., Kiowski, W., Lip, G., Mallion, J.-M., Manolis, A. J., Nilsson, P. M., O'Brien, E., Ponikowski, P., Redon, J., Ruschitzka, F., Tamargo, J., van Zwieten, P., Viigimaa, M., Waeber, B., Williams, B., Zamorano, J. L. (2007). 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 0: ehm236v1-75 [Full Text]  
• Schwartz, M. D, Dowell, D., Aperi, J., Kalet, A. L (2007). Improving journal club presentations, or, I can present that paper in under 10 minutes. Evid. Based Med. 12: 66-68 [Full Text]