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Previous Volume 353:1055-1057 September 8, 2005 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Endothelial injury and dysfunction are thought to be critical events in the pathogenesis of atherosclerosis. Thus, understanding the mechanisms that maintain and restore endothelial function may have important clinical implications. A series of clinical and basic studies prompted by the discovery of bone marrow–derived endothelial progenitor cells¹ have provided insights into these processes and opened a door to the development of new therapeutic approaches.

Growing evidence suggests that bone marrow–derived endothelial progenitor cells circulate in the blood and play an important role in the formation of new blood vessels as well as contribute to vascular homeostasis in the adult. Circulating . . . [Full Text of this Article]

Source Information

From the Program in Cardiovascular Gene Therapy, Massachusetts General Hospital, and Harvard Medical School — both in Boston.

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