FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 294:630-633 March 18, 1976 Number 12 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

Norepinephrine concentration and dopamine-beta-hydroxylase activity were measured in the plasma of 10 dysautonomic patients and 10 normal subjects while they were reclining, standing and exercising. While reclining, dysautonomic patients had normal norepinephrine concentrations and blood pressure, but after standing they did not have a normal increase in their levels of norepinephrine (P less than 0.005), dopamine-beta-hydroxylase (P less than 0.05) or plasma protein concentration (P less than 0.01); they became hypotensive. In reclining dysautonomic patients there appeared to be a correlation between blood pressure and plasma norepinephrine concentration. These data support the view that hypertension and hypotension in dysautonomia are related to the rate of norepinephrine release.

This article has been cited by other articles:

• Garland, E. M., Black, B. K., Harris, P. A., Robertson, D. (2007). Dopamine-beta-hydroxylase in postural tachycardia syndrome. Am. J. Physiol. Heart Circ. Physiol. 293: H684-H690 [Abstract] [Full Text]  
• Bernardi, L., Hilz, M., Stemper, B., Passino, C., Welsch, G., Axelrod, F. B. (2003). Respiratory and Cerebrovascular Responses to Hypoxia and Hypercapnia in Familial Dysautonomia. Am. J. Respir. Crit. Care Med. 167: 141-149 [Abstract] [Full Text]  
• Bickel, A, Axelrod, F B, Schmelz, M, Marthol, H, Hilz, M J (2002). Dermal microdialysis provides evidence for hypersensitivity to noradrenaline in patients with familial dysautonomia. J. Neurol. Neurosurg. Psychiatry 73: 299-302 [Abstract] [Full Text]  
• Axelrod, F. B., Zupanc, M., Hilz, M. J., Kramer, E. L. (2000). Ictal SPECT during autonomic crisis in familial dysautonomia. Neurology 55: 122-125 [Abstract] [Full Text]  
• Hilz, M. J., Stemper, B., Sauer, P., Haertl, U., Singer, W., Axelrod, F. B. (1999). Cold face test demonstrates parasympathetic cardiac dysfunction in familial dysautonomia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 276: R1833-R1839 [Abstract] [Full Text]  
• Hilz, M. J., Stemper, B., Axelrod, F. B. (1999). Sympathetic skin response differentiates hereditary sensory autonomic neuropathies III and IV. Neurology 52: 1652-1652 [Abstract] [Full Text]  
• Hilz, M. J, Kolodny, E. H, Neuner, I., Stemper, B., Axelrod, F. B (1998). Highly abnormal thermotests in familial dysautonomia suggest increased cardiac autonomic risk. J. Neurol. Neurosurg. Psychiatry 65: 338-343 [Abstract] [Full Text]