FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 308:1443-1447 June 16, 1983 Number 24 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

We evaluated a new antiviral agent, ribavirin, in the treatment of infants hospitalized with lower-respiratory-tract disease from respiratory syncytial virus. Ribavirin or placebo was administered to 33 infants in a double-blind manner by continuous aerosol for three to six days. Seventeen infants were treated with placebo, and 16 with ribavirin. By the end of treatment, infants receiving ribavirin had significantly greater improvement in their overall score for severity of illness, in lower-respiratory-tract signs, and in arterial oxygen saturation. Viral shedding was also diminished in the treated groups as compared with the placebo group. No side effects or toxicity were associated with the aerosol therapy. Isolates of respiratory syncytial virus obtained from the infants over the course of therapy showed no change in sensitivity to ribavirin.

This article has been cited by other articles:

• Subcommittee on Diagnosis and Management of Bronch, (2006). Diagnosis and Management of Bronchiolitis. Pediatrics 118: 1774-1793 [Abstract] [Full Text]  
• Liuzzi, M., Mason, S. W., Cartier, M., Lawetz, C., McCollum, R. S., Dansereau, N., Bolger, G., Lapeyre, N., Gaudette, Y., Lagace, L., Massariol, M.-J., Do, F., Whitehead, P., Lamarre, L., Scouten, E., Bordeleau, J., Landry, S., Rancourt, J., Fazal, G., Simoneau, B. (2005). Inhibitors of Respiratory Syncytial Virus Replication Target Cotranscriptional mRNA Guanylylation by Viral RNA-Dependent RNA Polymerase. J. Virol. 79: 13105-13115 [Abstract] [Full Text]  
• Mason, S. W., Lawetz, C., Gaudette, Y., Do, F., Scouten, E., Lagace, L., Simoneau, B., Liuzzi, M. (2004). Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identification of an inhibitor. Nucleic Acids Res 32: 4758-4767 [Abstract] [Full Text]  
• Easton, A. J., Domachowske, J. B., Rosenberg, H. F. (2004). Animal Pneumoviruses: Molecular Genetics and Pathogenesis. Clin. Microbiol. Rev. 17: 390-412 [Abstract] [Full Text]  
• King, V. J., Viswanathan, M., Bordley, W. C., Jackman, A. M., Sutton, S. F., Lohr, K. N., Carey, T. S. (2004). Pharmacologic Treatment of Bronchiolitis in Infants and Children: A Systematic Review. Arch Pediatr Adolesc Med 158: 127-137 [Abstract] [Full Text]  
• Bonville, C. A., Easton, A. J., Rosenberg, H. F., Domachowske, J. B. (2002). Altered Pathogenesis of Severe Pneumovirus Infection in Response to Combined Antiviral and Specific Immunomodulatory Agents. J. Virol. 77: 1237-1244 [Abstract] [Full Text]  
• Tam, R. C., Ramasamy, K., Bard, J., Pai, B., Lim, C., Averett, D. R. (2000). The Ribavirin Analog ICN 17261 Demonstrates Reduced Toxicity and Antiviral Effects with Retention of both Immunomodulatory Activity and Reduction of Hepatitis-Induced Serum Alanine Aminotransferase Levels. Antimicrob. Agents Chemother. 44: 1276-1283 [Abstract] [Full Text]  
• Tam, R. C., Lim, C., Bard, J., Pai, B. (1999). Contact Hypersensitivity Responses Following Ribavirin Treatment In Vivo Are Influenced by Type 1 Cytokine Polarization, Regulation of IL-10 Expression, and Costimulatory Signaling. J. Immunol. 163: 3709-3717 [Abstract] [Full Text]  
• Jordan, I., Briese, T., Averett, D. R., Lipkin, W. I. (1999). Inhibition of Borna Disease Virus Replication by Ribavirin. J. Virol. 73: 7903-7906 [Abstract] [Full Text]  
• GUERGUERIAN, A.-M., GAUTHIER, M., LEBEL, M. H., FARRELL, C. A., LACROIX, J. (1999). Ribavirin in Ventilated Respiratory Syncytial Virus Bronchiolitis . A Randomized, Placebo-controlled Trial. Am. J. Respir. Crit. Care Med. 160: 829-834 [Abstract] [Full Text]  
• Balfour, H. H. (1999). Antiviral Drugs. NEJM 340: 1255-1268 [Full Text]  
• Sudo, K., Watanabe, W., Konno, K., Sato, R., Kajiyashiki, T., Shigeta, S., Yokota, T. (1999). Efficacy of RD3-0028 Aerosol Treatment against Respiratory Syncytial Virus Infection in Immunosuppressed Mice. Antimicrob. Agents Chemother. 43: 752-757 [Abstract] [Full Text]  
• Domachowske, J. B., Rosenberg, H. F. (1999). Respiratory Syncytial Virus Infection: Immune Response, Immunopathogenesis, and Treatment. Clin. Microbiol. Rev. 12: 298-309 [Abstract] [Full Text]  
• MOLER, F. W., OHMIT, S. E. (1999). Severity Of Illness Models For Respiratory Syncytial Virus-Associated Hospitalization. Am. J. Respir. Crit. Care Med. 159: 1234-1240 [Abstract] [Full Text]  
• Fox, G. F, Everard, M. L, Marsh, M. J, Milner, A. D (1999). Randomised controlled trial of budesonide for the prevention of post-bronchiolitis wheezing. Arch. Dis. Child. 80: 343-347 [Abstract] [Full Text]  
• Rodriguez, W. J., Gruber, W. C., Groothuis, J. R., Simoes, E. A. F., Rosas, A. J., Lepow, M., , A. K., Hemming, V., the RSV-IGIV Study Group, (1997). Respiratory Syncytial Virus Immune Globulin Treatment of RSV Lower Respiratory Tract Infection in Previously Healthy Children. Pediatrics 100: 937-942 [Abstract] [Full Text]  
• Law, B. J., Wang, E. E. L., MacDonald, N., McDonald, J., Dobson, S., Boucher, F., Langley, J., Robinson, J., Mitchell, I., Stephens, D. (1997). Does Ribavirin Impact on the Hospital Course of Children With Respiratory Syncytial Virus (RSV) Infection? An Analysis Using the Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) RSV Database. Pediatrics 99: e7-e7 [Abstract] [Full Text]  
• Rodriguez, W. J., Gruber, W. C., Welliver, R. C., Groothuis, J. R., Simoes, E. A. F., Meissner, H. C., Hemming, V. G., Hall, C. B., Lepow, M. L., Rosas, A. J., Robertsen, C., Kramer, A. A. (1997). Respiratory Syncytial Virus (RSV) Immune Globulin Intravenous Therapy for RSV Lower Respiratory Tract Infection in Infants and Young Children at High Risk for Severe RSV Infections. Pediatrics 99: 454-461 [Abstract] [Full Text]  
• Randolph, A. G., Wang, E. E. L. (1996). Ribavirin for Respiratory Syncytial Virus Lower Respiratory Tract Infection: A Systematic Overview. Arch Pediatr Adolesc Med 150: 942-947 [Abstract]  
• Marks, M. I. (1992). Respiratory Syncytial Virus Infections. CLIN PEDIATR 31: 688-691  
• Aylward, R. B., Burdge, D. R. (1991). Ribavirin Therapy of Adult Respiratory Syncytial Virus Pneumonitis. Arch Intern Med 151: 2303-2304 [Abstract]  
• Takimoto, C. H., Cram, D. L., Root, R. K. (1991). Respiratory Syncytial Virus Infections on an Adult Medical Ward. Arch Intern Med 151: 706-708 [Abstract]  
• Herzog, K. D., Long, S. S., McGuigan, M., Fisher, M. C., Deforest, A. (1990). Impact of Treatment Guidelines on Use of Ribavirin. Arch Pediatr Adolesc Med 144: 1001-1004 [Abstract]  
• Balfour, H. H. Jr, Englund, J. A. (1989). Antiviral Drugs in Pediatrics. Arch Pediatr Adolesc Med 143: 1307-1316 [Abstract]  
• Bradley, J. S., Bastian, J. F., Connor, J. D. (1989). The Exposure of Health Care Workers to Ribavirin Aerosol. JAMA 262: 1948-1948 [Abstract]  
• (1988). Assessing Exposures of Health-Care Personnel to Aerosols of Ribavirin--California. JAMA 260: 1844-1845  
• Englund, J. A., Sullivan, C. J., Jordan, M. C., Dehner, L. P., Vercellotti, G. M., Balfour, H. H. Jr. (1988). Respiratory Syncytial Virus Infection in Immunocompromised Adults. ANN INTERN MED 109: 203-208 [Abstract]  
• RAY, C. G. (1988). Ribavirin: Ambivalence About an Antiviral Agent. Arch Pediatr Adolesc Med 142: 488-489 [Abstract]  
• Outwater, K. M., Meissner, H. C., Peterson, M. B. (1988). Ribavirin Administration to Infants Receiving Mechanical Ventilation. Arch Pediatr Adolesc Med 142: 512-515 [Abstract]  
• Wildin, S. R., Chonmaitree, T., Swischuk, L. E. (1988). Roentgenographic Features of Common Pediatric Viral Respiratory Tract Infections. Arch Pediatr Adolesc Med 142: 43-46 [Abstract]  
• Friedman, A. D., Naqvi, S. H., Arens, M. Q., Eyler, M. A. (1986). Value of Rapid Diagnosis of Respiratory Syncytial Virus Infection on Management of Small Infants. CLIN PEDIATR 25: 404-406 [Abstract]  
• Glezen, W. P., Taber, L. H., Frank, A. L., Kasel, J. A. (1986). Risk of Primary Infection and Reinfection With Respiratory Syncytial Virus. Arch Pediatr Adolesc Med 140: 543-546 [Abstract]  
• HALL, C. B., McBRIDE, J. T. (1986). Vapors, Viruses, and Views: Ribavirin and Respiratory Syncytial Virus. Arch Pediatr Adolesc Med 140: 331-332 [Abstract]  
• Hall, C. B., McBride, J. T., Gala, C. L., Hildreth, S. W., Schnabel, K. C. (1985). Ribavirin Treatment of Respiratory Syncytial Viral Infection in Infants With Underlying Cardiopulmonary Disease. JAMA 254: 3047-3051 [Abstract]  
• Padman, R., Bye, M. R., Schidlow, D. V., Zaeri, N. (1985). Severe RSV Bronchiolitis in an Immunocompromised Child. CLIN PEDIATR 24: 719-721 [Abstract]  
• LANE, H. C., FAUCI, A. S. (1985). Immunologic Reconstitution in the Acquired Immunodeficiency Syndrome. ANN INTERN MED 103: 714-718 [Abstract]  
• HIRSCH, M. S., KAPLAN, J. C. (1985). Prospects of Therapy for Infections with Human T-Lymphotropic Virus Type III. ANN INTERN MED 103: 750-755 [Abstract]  
• PATTERSON, W. B., CRAVEN, D. E., SCHWARTZ, D. A., NARDELL, E. A., KASMER, J., NOBLE, J. (1985). Occupational Hazards to Hospital Personnel. ANN INTERN MED 102: 658-680 [Abstract]  
• Dolin, R (1985). Antiviral chemotherapy and chemoprophylaxis. Science 227: 1296-1303 [Abstract]  
• McIntosh, K., Kurachek, S. C., Cairns, L. M., Burns, J. C., Goodspeed, B. (1984). Treatment of Respiratory Viral Infection in an Immunodeficient Infant With Ribavirin Aerosol. Arch Pediatr Adolesc Med 138: 305-308 [Abstract]