In a two-year prospective study, we examined the effect of respiratory viral infections on pulmonary function in 49 patients with cystic fibrosis (mean age, 13.7 years). Nineteen normal siblings (mean age, 14) served as controls. Subjects were assessed quarterly and at the time of any respiratory illness. Each assessment included nasal washes for viral isolation and blood drawing for respiratory viral serologic studies. Pulmonary-function tests were performed at least twice yearly. Respiratory illnesses were reported significantly more often in the patients (3.7 per year) than in the normal siblings (1.7 per year), although the frequency of proved viral infections (1.67 per year) was identical. In the patients with cystic fibrosis significant correlations (P less than 0.0001) were found between the annual incidence of viral infections and every measure of disease progression in the two-year period, including the rate of decline of the Shwachman score (r = 0.71), the percentage of ideal weight for height (r = 0.80), the forced vital capacity (r = 0.85), the forced expiratory volume in the first second (r = 0.84), the forced midexpiratory flow rate (r = 0.68), and the frequency (r = 0.53) and duration (r = 0.84) of hospitalizations for respiratory exacerbations. We conclude that frequency of viral respiratory infections is closely associated with pulmonary deterioration in patients with cystic fibrosis.
This article has been cited by other articles:
Jain, M., Thomson, A. H
(2009). Palivizumab, pneumococcal and influenza vaccination in cystic fibrosis. JRSM
102: 23-28
[Full Text]
van Ewijk, B. E., van der Zalm, M. M., Wolfs, T. F. W., Fleer, A., Kimpen, J. L. L., Wilbrink, B., van der Ent, C. K.
(2008). Prevalence and Impact of Respiratory Viral Infections in Young Children With Cystic Fibrosis: Prospective Cohort Study. Pediatrics
122: 1171-1176
[Abstract][Full Text]
Kukavica-Ibrulj, I, Levesque, R C
(2008). Animal models of chronic lung infection with Pseudomonas aeruginosa: useful tools for cystic fibrosis studies. Lab Anim
42: 389-412
[Abstract][Full Text]
Randell, S. H., Boucher, R. C., for the University of North Carolina Virtual Lung,
(2006). Effective Mucus Clearance Is Essential for Respiratory Health. Am. J. Respir. Cell Mol. Bio.
35: 20-28
[Full Text]
Davis, P. B.
(2006). Cystic Fibrosis Since 1938. Am. J. Respir. Crit. Care Med.
173: 475-482
[Abstract][Full Text]
Saiman, L., Siegel, J.
(2004). Infection Control in Cystic Fibrosis. Clin. Microbiol. Rev.
17: 57-71
[Abstract][Full Text]
Wat, D
(2003). Impact of respiratory viral infections on cystic fibrosis. Postgrad. Med. J.
79: 201-203
[Abstract][Full Text]
Kahn, J. S., Roberts, A., Weibel, C., Buonocore, L., Rose, J. K.
(2001). Replication-Competent or Attenuated, Nonpropagating Vesicular Stomatitis Viruses Expressing Respiratory Syncytial Virus (RSV) Antigens Protect Mice against RSV Challenge. J. Virol.
75: 11079-11087
[Abstract][Full Text]
Schaad, U. B., Bühlmann, U., Burger, R., Ruedeberg, A., Wilder-Smith, A., Rutishauser, M., Sennhauser, F., Herzog, C., Zellmeyer, M., Glück, R.
(2000). Comparison of Immunogenicity and Safety of a Virosome Influenza Vaccine with Those of a Subunit Influenza Vaccine in Pediatric Patients with Cystic Fibrosis. Antimicrob. Agents Chemother.
44: 1163-1167
[Abstract][Full Text]
Harvey, B.-G., Hackett, N. R., El-Sawy, T., Rosengart, T. K., Hirschowitz, E. A., Lieberman, M. D., Lesser, M. L., Crystal, R. G.
(1999). Variability of Human Systemic Humoral Immune Responses to Adenovirus Gene Transfer Vectors Administered to Different Organs. J. Virol.
73: 6729-6742
[Abstract][Full Text]
Hiatt, P. W., Grace, S. C., Kozinetz, C. A., Raboudi, S. H., Treece, D. G., Taber, L. H., Piedra, P. A.
(1999). Effects of Viral Lower Respiratory Tract Infection on Lung Function in Infants With Cystic Fibrosis. Pediatrics
103: 619-626
[Abstract][Full Text]
Piedra, P. A., Poveda, G. A., Ramsey, B., McCoy, K., Hiatt, P. W.
(1998). Incidence and Prevalence of Neutralizing Antibodies to the Common Adenoviruses in Children With Cystic Fibrosis: Implication for Gene Therapy With Adenovirus Vectors. Pediatrics
101: 1013-1019
[Abstract][Full Text]
Wang, E. E. L., Law, B. J., Robinson, J. L., Dobson, S., al Jumaah, S., Stephens, D., Boucher, F. D., McDonald, J., Mitchell, I., MacDonald, N. E.
(1997). PICNIC (Pediatric Investigators Collaborative Network on Infections in Canada) Study of the Role of Age and Respiratory Syncytial Virus Neutralizing Antibody on Respiratory Syncytial Virus Illness in Patients With Underlying Heart or Lung Disease. Pediatrics
99: e9-e9
[Abstract][Full Text]
Ramsey, B. W., Gore, E. J., Smith, A. L., Cooney, M. K., Redding, G. J., Foy, H.
(1989). The Effect of Respiratory Viral Infections on Patients With Cystic Fibrosis. Arch Pediatr Adolesc Med
143: 662-668
[Abstract]
Previous
