FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Volume 313:65-70 July 11, 1985 Number 2 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

To investigate the mechanisms responsible for the late-phase response in patients with allergies, we measured four biochemical mediators (histamine, tosyl-L-arginine methyl ester [TAME]-esterase, kinin, and prostaglandin D2) in nasal secretions after nasal challenge with pollen antigen in 12 patients with allergy. Nine patients had an immediate response and a recurrence of symptoms 3 to 11 hours after challenge. The clinical symptoms during recurrence were accompanied by a second increase in levels of histamine, TAME--esterase, and kinin over base-line values, although kinin levels were lower than during the immediate response. In contrast, although the levels of prostaglandin D2 were significantly increased during the immediate response, they did not increase above base line during the late response. Rechallenge with allergen 11 hours after the initial provocation, however, was associated with reappearance of all four biochemical mediators, including prostaglandin D2. We conclude that the late response to nasal challenge with allergen is accompanied by a second increase in the concentrations of histamine and TAME--esterase but differs from the immediate response in the lack of prostaglandin D2 production and in the amount of kinin generated. Since histamine is released only by mast cells and basophils and prostaglandin D2 is not produced by basophils, we suggest that these cells are partly responsible for the late-phase response.

This article has been cited by other articles:

• Suzukawa, M., Iikura, M., Koketsu, R., Nagase, H., Tamura, C., Komiya, A., Nakae, S., Matsushima, K., Ohta, K., Yamamoto, K., Yamaguchi, M. (2008). An IL-1 Cytokine Member, IL-33, Induces Human Basophil Activation via Its ST2 Receptor. J. Immunol. 181: 5981-5989 [Abstract] [Full Text]  
• Suzukawa, M., Komiya, A., Iikura, M., Nagase, H., Yoshimura-Uchiyama, C., Yamada, H., Kawasaki, H., Ohta, K., Matsushima, K., Hirai, K., Yamamoto, K., Yamaguchi, M. (2006). Trans-basement membrane migration of human basophils: role of matrix metalloproteinase-9. Int Immunol 18: 1575-1583 [Abstract] [Full Text]  
• Tschopp, C. M., Spiegl, N., Didichenko, S., Lutmann, W., Julius, P., Virchow, J. C., Hack, C. E., Dahinden, C. A. (2006). Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. Blood 108: 2290-2299 [Abstract] [Full Text]  
• Meltzer, E. O. (2005). Evaluation of the Optimal Oral Antihistamine for Patients With Allergic Rhinitis. Mayo Clin Proc. 80: 1170-1176 [Abstract]  
• Mimura, H., Ikemura, T., Kotera, O., Sawada, M., Tashiro, S., Fuse, E., Ueno, K., Manabe, H., Ohshima, E., Karasawa, A., Miyaji, H. (2005). Inhibitory Effect of the 4-Aminotetrahydroquinoline Derivatives, Selective Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cell Antagonists, on Eosinophil Migration Induced by Prostaglandin D2. J. Pharmacol. Exp. Ther. 314: 244-251 [Abstract] [Full Text]  
• Bhatia, S., Baroody, F. M., deTineo, M., Naclerio, R. M. (2005). Increased Nasal Airflow With Budesonide Compared With Desloratadine During the Allergy Season. Arch Otolaryngol Head Neck Surg 131: 223-228 [Abstract] [Full Text]  
• Sloane, D. E., Tedla, N., Awoniyi, M., MacGlashan, D. W. Jr, Borges, L., Austen, K. F., Arm, J. P. (2004). Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. Blood 104: 2832-2839 [Abstract] [Full Text]  
• Iikura, M., Ebisawa, M., Yamaguchi, M., Tachimoto, H., Ohta, K., Yamamoto, K., Hirai, K. (2004). Transendothelial Migration of Human Basophils. J. Immunol. 173: 5189-5195 [Abstract] [Full Text]  
• Dahlen, S-E, Kumlin, M (2004). Monitoring mast cell activation by prostaglandin D2 in vivo. Thorax 59: 453-455 [Full Text]  
• Quraishi, S. A., Davies, M. J., Craig, T. J. (2004). Inflammatory Responses in Allergic Rhinitis: Traditional Approaches and Novel Treatment Strategies. JAOA: Journal of the American Osteopathic Association 104: 7S-15S [Abstract] [Full Text]  
• Riechelmann, H., Deutschle, T., Friemel, E., Gross, H-J., Bachem, M. (2003). Biological markers in nasal secretions. Eur Respir J 21: 600-605 [Abstract] [Full Text]  
• Carayol, N., Vachier, I., Campbell, A., Crampette, L., Bousquet, J., Godard, P., Chanez, P. (2002). Regulation of E-cadherin expression by dexamethasone and tumour necrosis factor-{alpha} in nasal epithelium. Eur Respir J 20: 1430-1436 [Abstract] [Full Text]  
• Ronchetti, R., Villa, M. P., Martella, S., La Grutta, S., Ronchetti, F., Luca Biscione, G., Pagani, J., Falasca, C., Guglielmi, F., Barreto, M. (2002). Nasal Cellularity in 183 Unselected Schoolchildren Aged 9 to 11 Years. Pediatrics 110: 1137-1142 [Abstract] [Full Text]  
• Christiansen, S. C., Eddleston, J., Woessner, K. M., Chambers, S. S., Ye, R., Pan, Z. K., Zuraw, B. L. (2002). Up-Regulation of Functional Kinin B1 Receptors in Allergic Airway Inflammation. J. Immunol. 169: 2054-2060 [Abstract] [Full Text]  
• Caron, G., Delneste, Y., Roelandts, E., Duez, C., Bonnefoy, J.-Y., Pestel, J., Jeannin, P. (2001). Histamine Polarizes Human Dendritic Cells into Th2 Cell-Promoting Effector Dendritic Cells. J. Immunol. 167: 3682-3686 [Abstract] [Full Text]  
• BRAUNSTAHL, G.-J., OVERBEEK, S. E., FOKKENS, W. J., KLEINJAN, A., MCEUEN, A. R., WALLS, A. F., HOOGSTEDEN, H. C., PRINS, J.-B. (2001). Segmental Bronchoprovocation in Allergic Rhinitis Patients Affects Mast Cell and Basophil Numbers in Nasal and Bronchial Mucosa. Am. J. Respir. Crit. Care Med. 164: 858-865 [Abstract] [Full Text]  
• Arimura, A., Yasui, K., Kishino, J., Asanuma, F., Hasegawa, H., Kakudo, S., Ohtani, M., Arita, H. (2001). Prevention of Allergic Inflammation by a Novel Prostaglandin Receptor Antagonist, S-5751. J. Pharmacol. Exp. Ther. 298: 411-419 [Abstract] [Full Text]  
• Caron, G., Delneste, Y., Roelandts, E., Duez, C., Herbault, N., Magistrelli, G., Bonnefoy, J.-Y., Pestel, J., Jeannin, P. (2001). Histamine Induces CD86 Expression and Chemokine Production by Human Immature Dendritic Cells. J. Immunol. 166: 6000-6006 [Abstract] [Full Text]  
• Lewis, S. A., Pavord, I. D., Stringer, J. R., Knox, A. J., Weiss, S. T., Britton, J. R. (2001). The Relation Between Peripheral Blood Leukocyte Counts and Respiratory Symptoms, Atopy, Lung Function, and Airway Responsiveness in Adults. Chest 119: 105-114 [Abstract] [Full Text]  
• Falcone, F. H., Haas, H., Gibbs, B. F. (2000). The human basophil: a new appreciation of its role in immune responses. Blood 96: 4028-4038 [Full Text]  
• HOWARTH, P. H. (2000). Leukotrienes in Rhinitis. Am. J. Respir. Crit. Care Med. 161: S133-136 [Full Text]  
• Baroody, F. M., Ford, S., Proud, D., Kagey-Sobotka, A., Lichtenstein, L., Naclerio, R. M. (1999). Relationship between histamine and physiological changes during the early response to nasal antigen provocation. J. Appl. Physiol. 86: 659-668 [Abstract] [Full Text]  
• REYNOLDS, C. J., TOGIAS, A., PROUD, D. (1999). Airway Neural Responses to Kinins . Tachyphylaxis and Role of Receptor Subtypes. Am. J. Respir. Crit. Care Med. 159: 431-438 [Abstract] [Full Text]  
• Fujikura, T., Otsuka, H. (1998). Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1-Mediated Histamine Release From Human Nasal Mucosa. Arch Otolaryngol Head Neck Surg 124: 1331-1335 [Abstract] [Full Text]  
• Teshima, S., Rokutan, K., Nikawa, T., Kishi, K. (1998). Macrophage Colony-Stimulating Factor Stimulates Synthesis and Secretion of a Mouse Homolog of a Human IgE-Dependent Histamine-Releasing Factor by Macrophages In Vitro and In Vivo. J. Immunol. 161: 6356-6366 [Abstract] [Full Text]  
• Iikura, M., Yamaguchi, M., Fujisawa, T., Miyamasu, M., Takaishi, T., Morita, Y., Iwase, T., Moro, I., Yamamoto, K., Hirai, K. (1998). Secretory IgA Induces Degranulation of IL-3-Primed Basophils. J. Immunol. 161: 1510-1515 [Abstract] [Full Text]  
• Sabroe, R. A., Greaves, M. W. (1997). The Pathogenesis of Chronic Idiopathic Urticaria. Arch Dermatol 133: 1003-1008 [Abstract]  
• CALHOUN, W. J., LAVINS, B. J., MINKWITZ, M. C., EVANS, R., GLEICH, G. J., COHN, J. (1997). Effect of Zafirlukast (Accolate) on Cellular Mediators of Inflammation . Bronchoalveolar Lavage Fluid Findings after Segmental Antigen Challenge. Am. J. Respir. Crit. Care Med. 157: 1381-1389 [Abstract] [Full Text]  
• MacDonald, S., Rafnar, T, Langdon, J, Lichtenstein, L. (1995). Molecular identification of an IgE-dependent histamine-releasing factor. Science 269: 688-690 [Abstract]  
• Kaliner, M., Lemanske, R. (1992). Rhinitis and Asthma. JAMA 268: 2807-2829 [Abstract]  
• Flowers, B. K., Proud, D., Kagey-Sobotka, A., Lichtenstein, L. M., Naclerio, R. M. (1990). Localized Antigen Challenge of the Nasal Mucosa. Arch Otolaryngol Head Neck Surg 116: 1407-1410 [Abstract]  
• Druce, H. M., Kaliner, M. A. (1988). Allergic Rhinitis. JAMA 259: 260-263 [Abstract]  
• Kaliner, M., Eggleston, P. A., Mathews, K. P. (1987). Rhinitis and Asthma. JAMA 258: 2851-2873 [Abstract]  
• Creticos, P. S., Norman, P. S. (1987). Immunotherapy With Allergens. JAMA 258: 2874-2880 [Abstract]  
• Brown, M. S., Peters, S. P., Adkinson, N. F. Jr, Proud, D., Kagey-Sobotka, A., Norman, P. S., Lichtenstein, L. M., Naclerio, R. M. (1987). Arachidonic Acid Metabolites During Nasal Challenge. Arch Otolaryngol Head Neck Surg 113: 179-183 [Abstract]