A pattern of left ventricular hypertrophy evident on the electrocardiogram is a harbinger of morbidity and mortality from cardiovascular disease. Echocardiography permits the noninvasive determination of left ventricular mass and the examination of its role as a precursor of morbidity and mortality. We examined the relation of left ventricular mass to the incidence of cardiovascular disease, mortality from cardiovascular disease, and mortality from all causes in 3220 subjects enrolled in the Framingham Heart Study who were 40 years of age or older and free of clinically apparent cardiovascular disease, in whom left ventricular mass was determined echocardiographically. During a four-year follow-up period, there were 208 incident cardiovascular events, 37 deaths from cardiovascular disease, and 124 deaths from all causes. Left ventricular mass, determined echocardiographically, was associated with all outcome events. This relation persisted after we adjusted for age, diastolic blood pressure, pulse pressure, treatment for hypertension, cigarette smoking, diabetes, obesity, the ratio of total cholesterol to high-density lipoprotein cholesterol, and electrocardiographic evidence of left ventricular hypertrophy. In men, the risk factor-adjusted relative risk of cardiovascular disease was 1.49 for each increment of 50 g per meter in left ventricular mass corrected for the subject's height (95 percent confidence interval, 1.20 to 1.85); in women, it was 1.57 (95 percent confidence interval, 1.20 to 2.04). Left ventricular mass (corrected for height) was also associated with the incidence of death from cardiovascular disease (relative risk, 1.73 [95 percent confidence interval, 1.19 to 2.52] in men and 2.12 [95 percent confidence interval, 1.28 to 3.49] in women). Left ventricular mass (corrected for height) was associated with death from all causes (relative risk, 1.49 [95 percent confidence interval, 1.14 to 1.94] in men and 2.01 [95 percent confidence interval, 1.44 to 2.81] in women). We conclude that the estimation of left ventricular mass by echocardiography offers prognostic information beyond that provided by the evaluation of traditional cardiovascular risk factors. An increase in left ventricular mass predicts a higher incidence of clinical events, including death, attributable to cardiovascular disease.
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Framingham Heart Study, Mass. 01701.
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(2009). Exercise Training Alters Left Ventricular Geometry and Attenuates Heart Failure in Dahl Salt-Sensitive Hypertensive Rats. Hypertension
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[Abstract][Full Text]
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[Abstract]
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[Abstract][Full Text]
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(2009). Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction. Am. J. Physiol. Regul. Integr. Comp. Physiol.
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[Abstract][Full Text]
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(2009). Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction. Cardiovasc Res
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[Abstract][Full Text]
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[Abstract][Full Text]
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53: 292-294
[Full Text]
Semigran, M.
(2009). Myocardial effects of PDE5 inhibition: more function with less mass.. J Am Coll Cardiol
53: 216-217
[Full Text]
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[Abstract][Full Text]
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(2009). The 17-mm St. Jude Medical Regent Valve Is a Valid Option for Patients With a Small Aortic Annulus. Ann. Thorac. Surg.
87: 90-94
[Abstract][Full Text]
Quinones, M. A.
(2009). Role of echocardiography in predicting onset of heart failure in patients with stable coronary artery disease: is the whole greater than the sum of its parts?. J Am Coll Cardiol Img
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[Full Text]
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[Abstract][Full Text]
Bhuiyan, Md. S., Shioda, N., Shibuya, M., Iwabuchi, Y., Fukunaga, K.
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[Abstract][Full Text]
Kjeldsen, S. E., Aksnes, T. A., Fagard, R. H., Mancia, G.
(2009). CHAPTER 13 Hypertension. ESC Textbook of Cardiovascular Medicine
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[Abstract][Full Text]
Bluemke, D. A., Kronmal, R. A., Lima, J. A.C., Liu, K., Olson, J., Burke, G. L., Folsom, A. R.
(2008). The relationship of left ventricular mass and geometry to incident cardiovascular events: the MESA (Multi-Ethnic Study of Atherosclerosis) study.. J Am Coll Cardiol
52: 2148-2155
[Abstract][Full Text]
Kumarapeli, A. R.K., Su, H., Huang, W., Tang, M., Zheng, H., Horak, K. M., Li, M., Wang, X.
(2008). {alpha}B-Crystallin Suppresses Pressure Overload Cardiac Hypertrophy. Circ. Res.
103: 1473-1482
[Abstract][Full Text]
Borges, G. R., Salgado, H. C., Silva, C. A. A., Rossi, M. A., Prado, C. M., Fazan, R. Jr.
(2008). Changes in hemodynamic and neurohumoral control cause cardiac damage in one-kidney, one-clip hypertensive mice. Am. J. Physiol. Regul. Integr. Comp. Physiol.
295: R1904-R1913
[Abstract][Full Text]
Maillet, M., Purcell, N. H., Sargent, M. A., York, A. J., Bueno, O. F., Molkentin, J. D.
(2008). DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility. J. Biol. Chem.
283: 31246-31255
[Abstract][Full Text]
Kushwaha, S. S., Raichlin, E., Sheinin, Y., Kremers, W. K., Chandrasekaran, K., Brunn, G. J., Platt, J. L.
(2008). Sirolimus affects cardiomyocytes to reduce left ventricular mass in heart transplant recipients. Eur Heart J
29: 2742-2750
[Abstract][Full Text]
Pasquali, S. K., Li, J. S.
(2008). Prevention of Future Cardiovascular Disease in High-Risk Pediatric Patients: A Role for Lipid Lowering Therapy?. Circ Cardiovasc Qual Outcomes
1: 131-133
[Full Text]
Patel, R. K., Mark, P. B., Johnston, N., McGregor, E., Dargie, H. J., Jardine, A. G.
(2008). Renal Transplantation Is Not Associated with Regression of Left Ventricular Hypertrophy: A Magnetic Resonance Study. CJASN
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[Abstract][Full Text]
Pavlopoulos, H., Grapsa, J., Stefanadi, E., Kamperidis, V., Philippou, E., Dawson, D., Nihoyannopoulos, P.
(2008). The evolution of diastolic dysfunction in the hypertensive disease. Eur J Echocardiogr
9: 772-778
[Abstract][Full Text]
Dimopoulos, S., Nicosia, F., Donati, P., Prometti, P., De Vecchi, M., Zulli, R., Grassi, V.
(2008). QT Dispersion and Left Ventricular Hypertrophy in Elderly Hypertensive and Normotensive Patients. ANGIOLOGY
59: 605-612
[Abstract]
Watkins, H, Ashrafian, H, McKenna, W J
(2008). The genetics of hypertrophic cardiomyopathy: Teare redux. Heart
94: 1264-1268
[Full Text]
Nagarajarao, H. S., Penman, A. D., Taylor, H. A., Mosley, T. H., Butler, K., Skelton, T. N., Samdarshi, T. E., Aru, G., Fox, E. R.
(2008). The Predictive Value of Left Atrial Size for Incident Ischemic Stroke and All-Cause Mortality in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study. Stroke
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[Abstract][Full Text]
Verma, A., Meris, A., Skali, H., Ghali, J. K., Arnold, J. M. O., Bourgoun, M., Velazquez, E. J., McMurray, J. J.V., Kober, L., Pfeffer, M. A., Califf, R. M., Solomon, S. D.
(2008). Prognostic implications of left ventricular mass and geometry following myocardial infarction: the VALIANT (VALsartan In Acute myocardial iNfarcTion) Echocardiographic Study.. J Am Coll Cardiol Img
1: 582-591
[Abstract][Full Text]
Konstam, M. A.
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1: 592-594
[Full Text]
Fang, C. X., Dong, F., Thomas, D. P., Ma, H., He, L., Ren, J.
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295: H1206-H1215
[Abstract][Full Text]
Ruggenenti, P., Iliev, I., Costa, G. M., Parvanova, A., Perna, A., Giuliano, G. A., Motterlini, N., Ene-Iordache, B., Remuzzi, G., the BENEDICT Study Group,
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Sookoian, S, Gianotti, T F, Pirola, C J
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Niizeki, T., Takeishi, Y., Kitahara, T., Arimoto, T., Ishino, M., Bilim, O., Suzuki, S., Sasaki, T., Nakajima, O., Walsh, R. A., Goto, K., Kubota, I.
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295: H245-H255
[Abstract][Full Text]
Loyer, X., Gomez, A. M., Milliez, P., Fernandez-Velasco, M., Vangheluwe, P., Vinet, L., Charue, D., Vaudin, E., Zhang, W., Sainte-Marie, Y., Robidel, E., Marty, I., Mayer, B., Jaisser, F., Mercadier, J.-J., Richard, S., Shah, A. M., Benitah, J.-P., Samuel, J.-L., Heymes, C.
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117: 3187-3198
[Abstract][Full Text]
Grassi, G., Quarti-Trevano, F., Mancia, G.
(2008). Review: Cardioprotective effects of telmisartan in uncomplicated and complicated hypertension. Journal of Renin-Angiotensin-Aldosterone System
9: 66-74
[Abstract]
Duncan, A. I., Lowe, B. S., Garcia, M. J., Xu, M., Gillinov, A. M., Mihaljevic, T., Koch, C. G.
(2008). Influence of Concentric Left Ventricular Remodeling on Early Mortality After Aortic Valve Replacement. Ann. Thorac. Surg.
85: 2030-2039
[Abstract][Full Text]
Foster, B. J., Mackie, A. S., Mitsnefes, M., Ali, H., Mamber, S., Colan, S. D.
(2008). A Novel Method of Expressing Left Ventricular Mass Relative to Body Size in Children. Circulation
117: 2769-2775
[Abstract][Full Text]
Chami, H. A., Devereux, R. B., Gottdiener, J. S., Mehra, R., Roman, M. J., Benjamin, E. J., Gottlieb, D. J.
(2008). Left Ventricular Morphology and Systolic Function in Sleep-Disordered Breathing: The Sleep Heart Health Study. Circulation
117: 2599-2607
[Abstract][Full Text]
Alibin, C. P., Kopilas, M. A., Anderson, H. D. I.
(2008). Suppression of Cardiac Myocyte Hypertrophy by Conjugated Linoleic Acid: ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS {alpha} AND {gamma}. J. Biol. Chem.
283: 10707-10715
[Abstract][Full Text]
Frey, U. H., Lieb, W., Erdmann, J., Savidou, D., Heusch, G., Leineweber, K., Jakob, H., Hense, H.-W., Lowel, H., Brockmeyer, N. H., Schunkert, H., Siffert, W.
(2008). Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans. Eur Heart J
29: 888-897
[Abstract][Full Text]
Jacobshagen, C., Gruber, M., Teucher, N., Schmidt, A. G., Unsold, B. W., Toischer, K., Nguyen Van, P., Maier, L. S., Kogler, H., Hasenfuss, G.
(2008). Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction. Eur J Heart Fail
10: 334-342
[Abstract][Full Text]
Bell, J. R., Porrello, E. R., Huggins, C. E., Harrap, S. B., Delbridge, L. M. D.
(2008). The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy. Am. J. Physiol. Heart Circ. Physiol.
294: H1514-H1522
[Abstract][Full Text]
Coffman, T. M., Crowley, S. D.
(2008). Kidney in Hypertension: Guyton Redux. Hypertension
51: 811-816
[Full Text]
Hill, J. A., Olson, E. N.
(2008). Cardiac Plasticity. NEJM
358: 1370-1380
[Full Text]
Scholz, D., Baicu, C. F., Tuxworth, W. J., Xu, L., Kasiganesan, H., Menick, D. R., Cooper, G. IV
(2008). Microtubule-dependent distribution of mRNA in adult cardiocytes. Am. J. Physiol. Heart Circ. Physiol.
294: H1135-H1144
[Abstract][Full Text]
Verburg, B. O., Jaddoe, V. W.V., Wladimiroff, J. W., Hofman, A., Witteman, J. C.M., Steegers, E. A.P.
(2008). Fetal Hemodynamic Adaptive Changes Related to Intrauterine Growth: The Generation R Study. Circulation
117: 649-659
[Abstract][Full Text]
Mayosi, B. M., Avery, P. J., Farrall, M., Keavney, B., Watkins, H.
(2008). Genome-wide linkage analysis of electrocardiographic and echocardiographic left ventricular hypertrophy in families with hypertension. Eur Heart J
29: 525-530
[Abstract][Full Text]
Mancia, G., Grassi, G.
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(2008). Apoptosis Signal-Regulating Kinase 1/p38 Signaling Pathway Negatively Regulates Physiological Hypertrophy. Circulation
117: 545-552
[Abstract][Full Text]
Diwan, A., Wansapura, J., Syed, F. M., Matkovich, S. J., Lorenz, J. N., Dorn, G. W. II
(2008). Nix-Mediated Apoptosis Links Myocardial Fibrosis, Cardiac Remodeling, and Hypertrophy Decompensation. Circulation
117: 396-404
[Abstract][Full Text]
BAYLES, R. G., DAWOOD, T., LAMBERT, E. A., SCHLAICH, M. P., LAMBERT, G. W.
(2008). Elevated Cardiac Risk in Patients With Major Depressive Disorder. Am. J. Psychiatry
165: 137-137
[Full Text]
Chen, L., Zhang, J., Gan, T. X., Chen-Izu, Y., Hasday, J. D., Karmazyn, M., Balke, C. W., Scharf, S. M.
(2008). Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia. J. Appl. Physiol.
104: 218-223
[Abstract][Full Text]
Desai, N. D., Christakis, G. T.
(2008). Bioprosthetic Aortic Valve Replacement: Stented Pericardial and Porcine Valves. Card Surg Adult
3: 857-894
[Full Text]
Strand, A., Kjeldsen, S.E., Gudmundsdottir, H., Os, I., Smith, G., Bjornerheim, R.
(2008). Tissue Doppler imaging describes diastolic function in men prone to develop hypertension over twenty years. Eur J Echocardiogr
9: 34-39
[Abstract][Full Text]
van den Brink, O. W., Delbridge, L. M D., Pedrazzini, T., Rosenfeldt, F. L, Pepe, S.
(2007). Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression. Journal of Renin-Angiotensin-Aldosterone System
8: 153-159
[Abstract]
Iyem, H., Sekuri, C., Tavli, M., Buket, S.
(2007). Left Ventricular Hypertrophy and Remodeling after Aortic Valve Replacement. Asian Cardiovasc. Thorac. Ann.
15: 459-462
[Abstract][Full Text]
Rodriguez-Calvo, R., Serrano, L., Barroso, E., Coll, T., Palomer, X., Camins, A., Sanchez, R. M., Alegret, M., Merlos, M., Pallas, M., Laguna, J. C., Vazquez-Carrera, M.
(2007). Peroxisome Proliferator-Activated Receptor {alpha} Down-Regulation Is Associated With Enhanced Ceramide Levels in Age-Associated Cardiac Hypertrophy. Journals of Gerontology Series A: Biological Sciences and Medical Sciences
62: 1326-1336
[Abstract][Full Text]
Ferdinandy, P., Schulz, R., Baxter, G. F.
(2007). Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning. Pharmacol. Rev.
59: 418-458
[Abstract][Full Text]
Shimokawa, J., Yokoshiki, H., Tsutsui, H.
(2007). Impaired activation of ATP-sensitive K+ channels in endocardial myocytes from left ventricular hypertrophy. Am. J. Physiol. Heart Circ. Physiol.
293: H3643-H3649
[Abstract][Full Text]
Frank, D., Kuhn, C., van Eickels, M., Gehring, D., Hanselmann, C., Lippl, S., Will, R., Katus, H. A., Frey, N.
(2007). Calsarcin-1 Protects Against Angiotensin-II Induced Cardiac Hypertrophy. Circulation
116: 2587-2596
[Abstract][Full Text]
Meurrens, K., Ruf, S., Ross, G., Schleef, R., von Holt, K., Schluter, K.-D.
(2007). Smoking accelerates the progression of hypertension-induced myocardial hypertrophy to heart failure in spontaneously hypertensive rats. Cardiovasc Res
76: 311-322
[Abstract][Full Text]
Okin, P. M., Devereux, R. B., Harris, K. E., Jern, S., Kjeldsen, S. E., Lindholm, L. H., Dahlof, B., for the LIFE Study Investigators,
(2007). In-Treatment Resolution or Absence of Electrocardiographic Left Ventricular Hypertrophy Is Associated With Decreased Incidence of New-Onset Diabetes Mellitus in Hypertensive Patients: The Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) Study. Hypertension
50: 984-990
[Abstract][Full Text]
Auchus, R. J., Drazner, M. H.
(2007). Will the Lessons From Primary Aldosteronism Change the Treatment of Hypertension and Left Ventricular Hypertrophy?. Hypertension
50: 837-839
[Full Text]
Schlaich, M. P., Lambert, G. W., Lambert, E. A., Esler, M. D.
(2007). Letter by Schlaich et al Regarding Article, "Relationship Between Central Sympathetic Drive and Magnetic Resonance Imaging-Determined Left Ventricular Mass in Essential Hypertension". Circulation
116: e416-e416
[Full Text]
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