FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 328:680-684 March 11, 1993 Number 10 Next

	Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Despite the widespread use of intravenous thrombolytic therapy and of immediate percutaneous transluminal coronary angioplasty for the treatment of acute myocardial infarction, randomized comparisons of the two approaches to reperfusion are lacking. We report the results of a prospective, randomized trial comparing immediate coronary angioplasty (without previous thrombolytic therapy) with intravenous streptokinase treatment.

Methods A total of 142 patients with acute myocardial infarction were randomly assigned to receive one of the two treatments. The left ventricular ejection fraction was measured by radionuclide scanning before hospital discharge. Quantitative coronary angiography was performed to assess the degree of residual stenosis in the infarct-related arteries.

Results A total of 72 patients were assigned to receive streptokinase and 70 patients to undergo immediate angioplasty. Angioplasty was technically successful in 64 of the 65 patients who underwent the procedure. Infarction recurred in nine patients assigned to receive streptokinase, but in none of those assigned to receive angioplasty (P = 0.003 ). Fourteen patients in the streptokinase group had unstable angina after their infarction, but only four in the angioplasty group (P = 0.02). The mean (±SD) left ventricular ejection fraction as measured before discharge was 45 ±12 percent in the streptokinase group and 51 ±11 percent in the angioplasty group (P = 0.004). The infarct-related artery was patent in 68 percent of the patients in the streptokinase group and 91 percent of those in the angioplasty group (P = 0.001). Quantitative coronary angiography revealed stenosis of 36 ±20 percent of the luminal diameter in the angioplasty group, as compared with 76 ±19 percent in the streptokinase group (P<0.001).

Conclusions Immediate angioplasty after acute myocardial infarction was associated with a higher rate of patency of the infarct-related artery, a less severe residual stenotic lesion, better left ventricular function, and less recurrent myocardial ischemia and infarction than was intravenous streptokinase. .

Source Information

From the Departments of Cardiology (F.Z., M.J.B., J.C.A.H., H.S.) and Nuclear Medicine (S.R.), Ziekenhuis de Weezenlanden, Zwolle; and the Laboratory for Clinical and Experimental Image Processing, Department of Diagnostic Radiology and Nuclear Medicine, University Hospital, Leiden (J.H.C.R.) -- both in the Netherlands.

Address reprint requests to Dr. Zijlstra at Z.H. de Weezenlanden, Department of Cardiology, Groot Wezenland 20, 8011 JW Zwolle, the Netherlands.

Full Text of this Article

This article has been cited by other articles:

• Goodman, S. G., Menon, V., Cannon, C. P., Steg, G., Ohman, E. M., Harrington, R. A. (2008). Acute ST-Segment Elevation Myocardial Infarction: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 708S-775S [Abstract] [Full Text]  
• Ellis, S. G., Tendera, M., de Belder, M. A., van Boven, A. J., Widimsky, P., Janssens, L., Andersen, H.R., Betriu, A., Savonitto, S., Adamus, J., Peruga, J. Z., Kosmider, M., Katz, O., Neunteufl, T., Jorgova, J., Dorobantu, M., Grinfeld, L., Armstrong, P., Brodie, B. R., Herrmann, H. C., Montalescot, G., Neumann, F.-J., Effron, M. B., Barnathan, E. S., Topol, E. J., the FINESSE Investigators, (2008). Facilitated PCI in Patients with ST-Elevation Myocardial Infarction. NEJM 358: 2205-2217 [Abstract] [Full Text]  
• Busk, M., Maeng, M., Rasmussen, K., Kelbaek, H., Thayssen, P., Abildgaard, U., Vigholt, E., Mortensen, L. S., Thuesen, L., Kristensen, S. D., Nielsen, T. T., Andersen, H. R., for the DANAMI-2 Investigators, (2008). The Danish multicentre randomized study of fibrinolytic therapy vs. primary angioplasty in acute myocardial infarction (the DANAMI-2 trial): outcome after 3 years follow-up. Eur Heart J 29: 1259-1266 [Abstract] [Full Text]  
• Asseburg, C., Bravo Vergel, Y., Palmer, S., Fenwick, E., de Belder, M., Abrams, K. R, Sculpher, M. (2007). Assessing the effectiveness of primary angioplasty compared with thrombolysis and its relationship to time delay: a Bayesian evidence synthesis. Heart 93: 1244-1250 [Abstract] [Full Text]  
• Boden, W. E., Eagle, K., Granger, C. B. (2007). Reperfusion Strategies in Acute ST-Segment Elevation Myocardial Infarction: A Comprehensive Review of Contemporary Management Options. J Am Coll Cardiol 50: 917-929 [Abstract] [Full Text]  
• Lin, G. A., Dudley, R. A., Redberg, R. F. (2007). Cardiologists' Use of Percutaneous Coronary Interventions for Stable Coronary Artery Disease. Arch Intern Med 167: 1604-1609 [Abstract] [Full Text]  
• Timmer, J. R., Ottervanger, J. P., de Boer, M.-J., Boersma, E., Grines, C. L., Westerhout, C. M., Simes, R. J., Granger, C. B., Zijlstra, F., for the Primary Coronary Angioplasty vs Thrombolys, (2007). Primary Percutaneous Coronary Intervention Compared With Fibrinolysis for Myocardial Infarction in Diabetes Mellitus: Results From the Primary Coronary Angioplasty vs Thrombolysis-2 Trial. Arch Intern Med 167: 1353-1359 [Abstract] [Full Text]  
• Alexander, K. P., Newby, L. K., Armstrong, P. W., Cannon, C. P., Gibler, W. B., Rich, M. W., Van de Werf, F., White, H. D., Weaver, W. D., Naylor, M. D., Gore, J. M., Krumholz, H. M., Ohman, E. M. (2007). Acute Coronary Care in the Elderly, Part II: ST-Segment-Elevation Myocardial Infarction: A Scientific Statement for Healthcare Professionals From the American Heart Association Council on Clinical Cardiology: In Collaboration With the Society of Geriatric Cardiology. Circulation 115: 2570-2589 [Abstract] [Full Text]  
• Hollenbeak, C. S., Fitzgibbons, J. P., Rossi, M., Morris, D. L., Stillman, P. (2007). The Impact of Percutaneous Coronary Interventions on Outcomes for Acute Myocardial Infarction in Pennsylvania. American Journal of Medical Quality 22: 85-94 [Abstract]  
• van der Schaaf, R J, Timmer, J R, Ottervanger, J P, Hoorntje, J C A, de Boer, M-J, Suryapranata, H, Zijlstra, F, Dambrink, J-H E (2006). Long-term impact of multivessel disease on cause-specific mortality after ST elevation myocardial infarction treated with reperfusion therapy. Heart 92: 1760-1763 [Abstract] [Full Text]  
• Ting, H. H., Yang, E. H., Rihal, C. S. (2006). Narrative review: reperfusion strategies for ST-segment elevation myocardial infarction.. ANN INTERN MED 145: 610-617 [Abstract] [Full Text]  
• Stenestrand, U., Lindback, J., Wallentin, L., for the RIKS-HIA Registry, (2006). Long-term outcome of primary percutaneous coronary intervention vs prehospital and in-hospital thrombolysis for patients with ST-elevation myocardial infarction.. JAMA 296: 1749-1756 [Abstract] [Full Text]  
• Ozdemir, R., Sezgin, A. T., Barutcu, I., Topal, E., Gullu, H., Acikgoz, N. (2006). Comparison of Direct Stenting Versus Conventional Stent Implantation on Blood Flow in Patients With ST-Segment Elevation Myocardial Infarction. ANGIOLOGY 57: 453-458 [Abstract]  
• Henry, T. D., Atkins, J. M., Cunningham, M. S., Francis, G. S., Groh, W. J., Hong, R. A., Kern, K. B., Larson, D. M., Ohman, E. M., Ornato, J. P., Peberdy, M. A., Rosenberg, M. J., Weaver, W. D. (2006). ST-Segment Elevation Myocardial Infarction: Recommendations on Triage of Patients to Heart Attack Centers: Is it Time for a National Policy for the Treatment of ST-Segment Elevation Myocardial Infarction?. J Am Coll Cardiol 47: 1339-1345 [Abstract] [Full Text]  
• Boersma, E., The Primary Coronary Angioplasty vs. Thrombolysis, (2006). Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J 27: 779-788 [Abstract] [Full Text]  
• Henriques, J P S, Zijlstra, F, van 't Hof, A W J, de Boer, M-J, Dambrink, J-H E, Gosselink, A T M, Hoorntje, J C A, Ottervanger, J P, Suryapranata, H (2006). Primary percutaneous coronary intervention versus thrombolytic treatment: long term follow up according to infarct location. Heart 92: 75-79 [Abstract] [Full Text]  
• Huber, K., Caterina, R. D., Kristensen, S. D., Verheugt, F. W.A., Montalescot, G., Maestro, L. B., Werf, F. V. d., for the Task Force on Pre-hospital Reperfusion The, (2005). Pre-hospital reperfusion therapy: a strategy to improve therapeutic outcome in patients with ST-elevation myocardial infarction. Eur Heart J 26: 2063-2074 [Full Text]  
• Thiele, H., Engelmann, L., Elsner, K., Kappl, M. J., Storch, W.-H., Rahimi, K., Hartmann, A., Pfeiffer, D., Kneissl, G. D., Schneider, D., Moller, T., Heberling, H. J., Weise, I., Schuler, G., for the Leipzig Prehospital Fibrinolysis Group, (2005). Comparison of pre-hospital combination-fibrinolysis plus conventional care with pre-hospital combination-fibrinolysis plus facilitated percutaneous coronary intervention in acute myocardial infarction. Eur Heart J 26: 1956-1963 [Abstract] [Full Text]  
• Magid, D. J., Wang, Y., Herrin, J., McNamara, R. L., Bradley, E. H., Curtis, J. P., Pollack, C. V. Jr, French, W. J., Blaney, M. E., Krumholz, H. M. (2005). Relationship Between Time of Day, Day of Week, Timeliness of Reperfusion, and In-Hospital Mortality for Patients With Acute ST-Segment Elevation Myocardial Infarction. JAMA 294: 803-812 [Abstract] [Full Text]  
• (2005). Reperfusion in acute myocardial infarction. DTB 43: 49-53 [Abstract] [Full Text]  
• Ilkay, E., Karaca, I., Yavuzkir, M., Akbulut, M., Pekdemir, M. (2005). The Effect of Interventional Treatment in Acute Myocardial Infarction on ST Resolution: A Comparison of Coronary Angioplasty with Excimer Laser Angioplasty. ANGIOLOGY 56: 377-384 [Abstract]  
• Suryapranata, H, De Luca, G, van 't Hof, A W J, Ottervanger, J P, Hoorntje, J C A, Dambrink, J-H E, Gosselink, A T M, Zijlstra, F, de Boer, M-J (2005). Is routine stenting for acute myocardial infarction superior to balloon angioplasty? A randomised comparison in a large cohort of unselected patients. Heart 91: 641-645 [Abstract] [Full Text]  
• de Kam, P. J, Voors, A. A, Fici, F., van Veldhuisen, D. J, van Gilst, W. H (2004). Review: The revised role of ACE-inhibition after myocardial infarction in the thrombolytic/primary PCI era. Journal of Renin-Angiotensin-Aldosterone System 5: 161-168 [Abstract]  
• de Jaegere, P. P, Serruys, P. W, Simoons, M. L (2004). Should all patients with an acute myocardial infarction be referred for direct PTCA?. Heart 90: 1352-1357 [Full Text]  
• Menon, V., Harrington, R. A., Hochman, J. S., Cannon, C. P., Goodman, S. D., Wilcox, R. G., Schunemann, H. J., Ohman, E. M. (2004). Thrombolysis and Adjunctive Therapy in Acute Myocardial Infarction: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 549S-575S [Abstract] [Full Text]  
• Writing Committee Members, , Antman, E. M., Anbe, D. T., Armstrong, P. W., Bates, E. R., Green, L. A., Hand, M., Hochman, J. S., Krumholz, H. M., Kushner, F. G., Lamas, G. A., Mullany, C. J., Ornato, J. P., Pearle, D. L., Sloan, M. A., Smith, S. C. Jr, Task Force Members, , Antman, E. M., Smith, S. C. Jr, Alpert, J. S., Anderson, J. L., Faxon, D. P., Fuster, V., Gibbons, R. J., Gregoratos, G., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Jacobs, A. K., Ornato, J. P. (2004). ACC/AHA guidelines for the management of patients with ST-Elevation myocardial infarction--executive summary: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (writing committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction) . J Am Coll Cardiol 44: 671-719 [Full Text]  
• Antman, E. M., Anbe, D. T., Armstrong, P. W., Bates, E. R., Green, L. A., Hand, M., Hochman, J. S., Krumholz, H. M., Kushner, F. G., Lamas, G. A., Mullany, C. J., Ornato, J. P., Pearle, D. L., Sloan, M. A., Smith, S. C. Jr, Antman, E. M., Smith, S. C. Jr, Alpert, J. S., Anderson, J. L., Faxon, D. P., Fuster, V., Gibbons, R. J., Gregoratos, G., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Jacobs, A. K., Ornato, J. P. (2004). ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). Circulation 110: 588-636 [Full Text]  
• Kloner, R. A., Rezkalla, S. H. (2004). Cardiac protection during acute myocardial infarction: Where do we stand in 2004?. J Am Coll Cardiol 44: 276-286 [Abstract] [Full Text]  
• Wu, W.-C., Gordon, P. C. (2004). Invasive Management of Patients With ST Elevation Myocardial Infarction With > 12-h Delay in Presentation: The Question Remains Unanswered. Chest 126: 2-4 [Full Text]  
• Brodie, B. R. (2004). Primary percutaneous coronary intervention at hospitals without on-site cardiac surgery: Expanding the use of mechanical reperfusion for acute myocardial infarction. J Am Coll Cardiol 43: 1951-1953 [Full Text]  
• Timmer, J. R, Ottervanger, J. P., Thomas, K., Hoorntje, J. C.A, de Boer, M.-J., Suryapranata, H., Zijlstra, F., on behalf of the Zwolle myocardial infarction stud, (2004). Long-term, cause-specific mortality after myocardial infarction in diabetes. Eur Heart J 25: 926-931 [Abstract] [Full Text]  
• Montalescot, G, Andersen, H R, Antoniucci, D, Betriu, A, de Boer, M J, Grip, L, Neumann, F J, Rothman, M T (2004). Recommendations on percutaneous coronary intervention for the reperfusion of acute ST elevation myocardial infarction. Heart 90: e37-e37 [Abstract] [Full Text]  
• Antman, E. M., Van de Werf, F. (2004). Pharmacoinvasive Therapy: The Future of Treatment for ST-Elevation Myocardial Infarction. Circulation 109: 2480-2486 [Full Text]  
• Mehta, R. H., Harjai, K. J., Grines, L., Stone, G. W., Boura, J., Cox, D., O'Neill, W., Grines, C. L., Primary Angioplasty in Myocardial Infarction (PAMI, (2004). Sustained ventricular tachycardia or fibrillation in the cardiac catheterization laboratory among patients receiving primary percutaneous coronary intervention: Incidence, predictors, and outcomes. J Am Coll Cardiol 43: 1765-1772 [Abstract] [Full Text]  
• Buttner, H. J., Neumann, F.-J. (2004). Tirofiban for catheter intervention in acute myocardial infarction?. Eur Heart J 25: 807-809 [Full Text]  
• Elsman, P, van `t Hof, A.W.J, de Boer, M.J, Hoorntje, J.C.A, Suryapranata, H, Dambrink, J.H.E, Zijlstra, F, on behalf of the Zwolle Myocardial Infarction Stud, (2004). Role of collateral circulation in the acute phase of ST-segment-elevation myocardial infarction treated with primary coronary intervention. Eur Heart J 25: 854-858 [Abstract] [Full Text]  
• De Luca, G., Ernst, N., Zijlstra, F., van't Hof, A. W. J., Hoorntje, J. C. A., Dambrink, J.-H. E., Gosslink, A. T. M., de Boer, M.-J., Suryapranata, H. (2004). Preprocedural TIMI flow and mortality in patients with acute myocardial infarction treated by primary angioplasty. J Am Coll Cardiol 43: 1363-1367 [Abstract] [Full Text]  
• Le May, M. R., Davies, R. F., Labinaz, M., Sherrard, H., Marquis, J.-F., Laramee, L. A., O'Brien, E. R., Williams, W. L., Beanlands, R. S., Nichol, G., Higginson, L. A. (2003). Hospitalization Costs of Primary Stenting Versus Thrombolysis in Acute Myocardial Infarction: Cost Analysis of the Canadian STAT Study. Circulation 108: 2624-2630 [Abstract] [Full Text]  
• Mehta, R. H., Harjai, K. J., Cox, D., Stone, G. W., Brodie, B., Boura, J., O'Neill, W., Grines, C. L., Primary Angioplasty in Myocardial Infarction (PAMI, (2003). Clinical and angiographic correlates and outcomes of suboptimal coronary flow inpatients with acute myocardial infarction undergoing primary percutaneous coronary intervention. J Am Coll Cardiol 42: 1739-1746 [Abstract] [Full Text]  
• Morrison, D. A. (2003). Counterintuitive contributionsto the care of myocardialinfarction and theneed for randomized trials. J Am Coll Cardiol 42: 978-980 [Full Text]  
• van der Horst, I. C. C., Zijlstra, F., van't Hof, A. W. J., Doggen, C. J. M., de Boer, M.-J., Suryapranata, H., Hoorntje, J. C. A., Dambrink, J.-H. E., Gans, R. O. B., Bilo, H. J. G., Zwolle Infarct Study Group, (2003). Glucose-insulin-potassium infusion inpatients treated with primary angioplasty for acute myocardial infarction: The glucose-insulin-potassium study: a randomized trial. J Am Coll Cardiol 42: 784-791 [Abstract] [Full Text]  
• Andersen, H. R., Nielsen, T. T., Rasmussen, K., Thuesen, L., Kelbaek, H., Thayssen, P., Abildgaard, U., Pedersen, F., Madsen, J. K., Grande, P., Villadsen, A. B., Krusell, L. R., Haghfelt, T., Lomholt, P., Husted, S. E., Vigholt, E., Kjaergard, H. K., Mortensen, L. S., the DANAMI-2 Investigators, (2003). A Comparison of Coronary Angioplasty with Fibrinolytic Therapy in Acute Myocardial Infarction. NEJM 349: 733-742 [Abstract] [Full Text]  
• Eisenberg, M. J., Jamal, S. (2003). Glycoprotein IIb/IIIa inhibition in the setting of acute ST-segment elevation myocardial infarction. J Am Coll Cardiol 42: 1-6 [Abstract] [Full Text]  
• Moliterno, D. J., Chan, A. W. (2003). Glycoprotein IIb/IIIa inhibition in early intent-to-stent treatment of acute coronary syndromes: EPISTENT, ADMIRAL, CADILLAC, and TARGET. J Am Coll Cardiol 41: 49S-54S [Abstract] [Full Text]  
• Beygui, F, Le Feuvre, C, Helft, G, Maunoury, C, Metzger, J P (2003). Myocardial viability, coronary flow reserve, and in-hospital predictors of late recovery of contractility following successful primary stenting for acute myocardial infarction. Heart 89: 179-183 [Abstract] [Full Text]  
• The Task Force on the Management of Acute Myocardi, , Van de Werf, F., Ardissino, D., Betriu, A., Cokkinos, D. V., Falk, E., Fox, K. A.A., Julian, D., Lengyel, M., Neumann, F.-J., Ruzyllo, W., Thygesen, C., Underwood, S. R., Vahanian, A., Verheugt, F. W.A., Wijns, W. (2003). Management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 24: 28-66 [Full Text]  
• Widimsky, P., Budesinsky, T., Vorac, D., Groch, L., Zelizko, M., Aschermann, M., Branny, M., St'asek, J., Formanek, P., on behalf of the 'PRAGUE' Study Group Investigator, (2003). Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction: Final results of the randomized national multicentre trial--PRAGUE-2. Eur Heart J 24: 94-104 [Abstract] [Full Text]  
• Canto, J. G., Zalenski, R. J., Ornato, J. P., Rogers, W. J., Kiefe, C. I., Magid, D., Shlipak, M. G., Frederick, P. D., Lambrew, C. G., Littrell, K. A., Barron, H. V., for the National Registry of Myocardial Infarction, (2002). Use of Emergency Medical Services in Acute Myocardial Infarction and Subsequent Quality of Care: Observations From the National Registry of Myocardial Infarction 2. Circulation 106: 3018-3023 [Abstract] [Full Text]  
• Yamamoto, K., Ito, H., Iwakura, K., Kawano, S., Ikushima, M., Masuyama, T., Ogihara, T., Fujii, K. (2002). Two different coronary blood flow velocity patterns in thrombolysis in myocardial infarction flow grade 2 in acute myocardial infarction: Insight into mechanisms of microvascular dysfunction. J Am Coll Cardiol 40: 1755-1760 [Abstract] [Full Text]  
• Bolognese, L., Neskovic, A. N., Parodi, G., Cerisano, G., Buonamici, P., Santoro, G. M., Antoniucci, D. (2002). Left Ventricular Remodeling After Primary Coronary Angioplasty: Patterns of Left Ventricular Dilation and Long-Term Prognostic Implications. Circulation 106: 2351-2357 [Abstract] [Full Text]  
• Ronner, E., van Domburg, R.T., van den Brand, M.J.B.M., de Feyter, P.J., Foley, D.P., van der Giessen, W.J., Serruys, P.W., Simoons, M.L. (2002). Platelet GP IIb/IIIa receptor blockers for failed thrombolysis in acute myocardial infarction, alone or as adjunct to other rescue therapies. A single centre retrospective analysis of 548 consecutive patients with acute myocardial infarction. Eur Heart J 23: 1529-1537 [Abstract] [Full Text]  
• Mehta, R. H., Criger, D. A., Granger, C. B., Pieper, K. K., Califf, R. M., Topol, E. J., Bates, E. R. (2002). Patient outcomes after fibrinolytic therapy for acute myocardial infarction at hospitals with and without coronary revascularization capability. J Am Coll Cardiol 40: 1034-1040 [Abstract] [Full Text]  
• Hsu, L F, Mak, K H, Lau, K W, Sim, L L, Chan, C, Koh, T H, Chuah, S C, Kam, R, Ding, Z P, Teo, W S, Lim, Y L (2002). Clinical outcomes of patients with diabetes mellitus and acute myocardial infarction treated with primary angioplasty or fibrinolysis. Heart 88: 260-265 [Abstract] [Full Text]  
• Widimsky, P. (2002). Reperfusion damage or no-reflow damage in primary coronary interventions in acute myocardial infarction?. Eur Heart J 23: 1076-1078 [Full Text]  
• Singh, M., Ting, H. H., Berger, P. B., Garratt, K. N., Holmes, D. R. Jr, Gersh, B. J. (2002). Rationale for on-site cardiac surgery for primary angioplasty: a time for reappraisal. J Am Coll Cardiol 39: 1881-1889 [Abstract] [Full Text]  
• Cannon, C. P., Baim, D. S. (2002). Expanding the reach of primary percutaneous coronary intervention for the treatment of acute myocardial infarction. J Am Coll Cardiol 39: 1720-1722 [Full Text]  
• de Boer, M.-J., Ottervanger, J.-P., van't Hof, A. W. J., Hoorntje, J. C. A., Suryapranata, H., Zijlstra, F., the Zwolle Myocardial Infarction Study Group, (2002). Reperfusion therapy in elderly patients with acute myocardial infarction: A randomized comparison of primary angioplasty and thrombolytic therapy. J Am Coll Cardiol 39: 1723-1728 [Abstract] [Full Text]  
• Braunwald, E. (2002). Reperfusion therapy for acute myocardial infarction: historical context and future promise. Eur Heart J Suppl 4: E10-E14 [Abstract]  
• Aversano, T., Aversano, L. T., Passamani, E., Knatterud, G. L., Terrin, M. L., Williams, D. O., Forman, S. A., for the Atlantic Cardiovascular Patient Outcomes R, (2002). Thrombolytic Therapy vs Primary Percutaneous Coronary Intervention for Myocardial Infarction in Patients Presenting to Hospitals Without On-site Cardiac Surgery: A Randomized Controlled Trial. JAMA 287: 1943-1951 [Abstract] [Full Text]  
• Zijlstra, F, Patel, A, Jones, M, Grines, C.L, Ellis, S, Garcia, E, Grinfeld, L, Gibbons, R.J, Ribeiro, E.E, Ribichini, F, Granger, C, Akhras, F, Weaver, W.D, Simes, R.J (2002). Clinical characteristics and outcome of patients with early (<2h), intermediate (2-4h) and late (>4h) presentation treated by primary coronary angioplasty or thrombolytic therapy for acute myocardial infarction. Eur Heart J 23: 550-557 [Abstract] [Full Text]  
• Moreno, R., Lopez-Sendon, J., Garcia, E., de Isla, L. P.e., de Sa, E. L.o., Ortega, A., Moreno, M., Rubio, R., Soriano, J., Abeytua, M., Garcia-Fernandez, M.-A. (2002). Primary angioplasty reduces the risk of left ventricular free wall rupture compared with thrombolysis in patients with acute myocardial infarction. J Am Coll Cardiol 39: 598-603 [Abstract] [Full Text]  
• Spacek, R., Widimsky, P., Straka, Z., Jiresova, E., Dvorak, J., Polasek, R., Karel, I., Jirmar, R., Lisa, L., Budesinsky, T., Malek, F., Stanka, P. (2002). V_alue of First Day Angiography/Angioplasty I_n Evolving N_on-ST Segment Elevation Myocardial Infarction: An O_pen Multicenter Randomized Trial. The VINO Study. Eur Heart J 23: 230-238 [Abstract] [Full Text]  
• Loubeyre, C., Morice, M.-C., Lefevre, T., Piechaud, J.-F., Louvard, Y., Dumas, P. (2002). A randomized comparison of direct stenting with conventional stent implantation in selected patients with acute myocardial infarction. J Am Coll Cardiol 39: 15-21 [Abstract] [Full Text]  
• Hasumura, Y., Aoki, N., Kawano, K., Homori, M., Maki, A., Hioki, Y., Ishikawa, K., Yoshino, H. (2001). Platelet-Dependent Thrombin Generation in Patients with Unstable Angina Pectoris. ANGIOLOGY 52: 811-818 [Abstract]  
• Hatada, K., Sugiura, T., Kamihata, H., Nakamura, S., Takahashi, N., Yuasa, F., Iwasaka, T. (2001). Clinical Significance of Coronary Flow to the Infarct Zone Before Successful Primary Percutaneous Transluminal Coronary Angioplasty in Acute Myocardial Infarction. Chest 120: 1959-1963 [Abstract] [Full Text]  
• HAMPTON, J. (2001). Immediate angioplasty for the National Health Service?. Heart 86: 241-242 [Full Text]  
• GITT, A K, SENGES, J (2001). The patient with acute myocardial infarction who does not receive reperfusion treatment. Heart 86: 243-245 [Full Text]  
• Kamp, O, Lepper, W, Vanoverschelde, J.-L, Aeschbacher, B.C, Rovai, D, Assayag, P, Voci, P, Kloster, Y, Distante, A, Visser, C.A (2001). Serial evaluation of perfusion defects in patients with a first acute myocardial infarction referred for primary PTCA using intravenous myocardial contrast echocardiography. Eur Heart J 22: 1485-1495 [Abstract]  
• Sheiban, I., Fragasso, G., Rosano, G. M. C., Dharmadhikari, A., Tzifos, V., Pagnotta, P., Chierchia, S. L., Trevi, G. (2001). Time course and determinants of left ventricular function recovery after primary angioplasty in patients with acute myocardial infarction. J Am Coll Cardiol 38: 464-471 [Abstract] [Full Text]  
• Akkerhuis, K. M., Deckers, J. W., Lincoff, A. M., Tcheng, J. E., Boersma, E., Anderson, K., Balog, C., Califf, R. M., Topol, E. J., Simoons, M. L. (2001). Risk of Stroke Associated With Abciximab Among Patients Undergoing Percutaneous Coronary Intervention. JAMA 286: 78-82 [Abstract] [Full Text]  
• Smith, S. C. Jr, Dove, J. T., Jacobs, A. K., Ward Kennedy, J., Kereiakes, D., Kern, M. J., Kuntz, R. E., Popma, J. J., Schaff, H. V., Williams, D. O., Gibbons, R. J., Alpert, J. P., Eagle, K. A., Faxon, D. P., Fuster, V., Gardner, T. J., Gregoratos, G., Russell, R. O., Smith, S. C. Jr (2001). ACC/AHA guidelines for percutaneous coronary intervention (revision of the 1993 PTCA guidelines): A report of the American College of Cardiology/ American Heart Association Task Force on practice guidelines (Committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty) endorsed by the Society for Cardiac Angiography and Interventions. J Am Coll Cardiol 37: 2239-2239 [Full Text]  
• Zahn, R., Schiele, R., Schneider, S., Gitt, A. K., Wienbergen, H., Seidl, K., Voigtlander, T., Gottwik, M., Berg, G., Altmann, E., Rosahl, W., Senges, J., for the Maximal Individual Therapy in Acute Myocar, (2001). Primary angioplasty versus intravenous thrombolysis in acute myocardial infarction: can we define subgroups of patients benefiting most from primary angioplasty?: Results from the pooled data of the maximal individual therapy in acute myocardial infarction registry and the myocardial infarction registry. J Am Coll Cardiol 37: 1827-1835 [Abstract] [Full Text]  
• Every, N. R., Lehmann, K. G. (2001). The effectiveness of primary PTCA: does patient risk matter?. J Am Coll Cardiol 37: 1836-1838 [Full Text]  
• Ryden, L., Sjoquist, P.-O., Wang, Q.-D. (2001). Pharmacological tools for the limitation of myocardial reperfusion injury: Experimental evidence. Eur Heart J Suppl 3: C28-C35 [Abstract]  
• Widimsky, P. (2001). Pharmacological versus catheter-based reperfusion: What is present state of the art?. Eur Heart J Suppl 3: C47-C54 [Abstract]  
• Ottervanger, J.P, Van't Hof, A.W.J, Reiffers, S, Hoorntje, J.C.A, Suryapranata, H, de Boer, M.J, Zijlstra, F (2001). Long-term recovery of left ventricular function after primary angioplasty for acute myocardial infarction. Eur Heart J 22: 785-790 [Abstract]  
• Otasevic, P, Neskovic, A N, Popovic, Z, Vlahovic, A, Bojic, D, Bojic, M, Popovic, A D (2001). Short early filling deceleration time on day 1 after acute myocardial infarction is associated with short and long term left ventricular remodelling. Heart 85: 527-532 [Abstract] [Full Text]  
• Montalescot, G., Choussat, R., Collet, J.P. (2001). Glycoprotein IIb/IIIa receptors and primary stenting in acute myocardial infarction. Eur Heart J Suppl 3: A3-A7 [Abstract]  
• Herrmann, H.C., Li, R.H., Ohman, E.M. (2001). Facilitated percutaneous coronary intervention: results from the SPEED trial. Eur Heart J Suppl 3: A26-A34 [Abstract]  
• Yamasaki, Y., Miyoshi, K., Oda, N., Watanabe, M., Miyake, H., Chan, J., Wang, X., Sun, L., Tang, C., McMahon, G., Lipson, K. E. (2001). Weekly Dosing With the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor SU9518 Significantly Inhibits Arterial Stenosis. Circ. Res. 88: 630-636 [Abstract] [Full Text]  
• Le May, M. R., Labinaz, M., Davies, R. F., Marquis, J.-F., Laramee, L. A., O'Brien, E. R., Williams, W. L., Beanlands, R. S., Nichol, G., Higginson, L. A. (2001). Stenting versus thrombolysis in acute myocardial infarction trial (STAT). J Am Coll Cardiol 37: 985-991 [Abstract] [Full Text]  
• Kovac, J.D., Gershlick, A.H. (2001). How should we detect and manage failed thrombolysis?. Eur Heart J 22: 450-457  
• Magid, D. J., Calonge, B. N., Rumsfeld, J. S., Canto, J. G., Frederick, P. D., Every, N. R., Barron, H. V., for the National Registry of Myocardial Infarction, (2000). Relation Between Hospital Primary Angioplasty Volume and Mortality for Patients With Acute MI Treated With Primary Angioplasty vs Thrombolytic Therapy. JAMA 284: 3131-3138 [Abstract] [Full Text]  
• Zahn, R., Schiele, R., Schneider, S., Gitt, A. K., Wienbergen, H., Seidl, K., Bossaller, C., Buttner, H. J., Gottwik, M., Altmann, E., Rosahl, W., Senges, J., for the Maximal Individual Therapy in Acute Myocar, (2000). Decreasing hospital mortality between 1994 and 1998 in patients with acute myocardial infarction treated with primary angioplasty but not in patients treated with intravenous thrombolysis: Results from the pooled data of the maximal individual therapy in acute myocardial infarction (MITRA) registry and the myocardial infarction registry (MIR). J Am Coll Cardiol 36: 2064-2071 [Abstract] [Full Text]  
• Sasao, H, Tsuchihashi, K, Hase, M, Nakata, T, Shimamoto, K, investigators, t. N.-9. (2000). Does primary stenting preserve cardiac function in myocardial infarction? A case-control study. Heart 84: 515-521 [Abstract] [Full Text]  
• Hannan, E. L., Racz, M. J., Arani, D. T., Ryan, T. J., Walford, G., McCallister, B. D. (2000). Short- and long-term mortality for patients undergoing primary angioplasty for acute myocardial infarction. J Am Coll Cardiol 36: 1194-1201 [Abstract] [Full Text]  
• Wong, S. C., Sanborn, T., Sleeper, L. A., Webb, J. G., Pilchik, R., Hart, D., Mejnartowicz, S., Antonelli, T. A., Lange, R., French, J. K., Bergman, G., LeJemtel, T., Hochman, J. S., for the SHOCK Investigators, (2000). Angiographic findings and clinical correlates in patients with cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry. J Am Coll Cardiol 36: 1077-1083 [Abstract] [Full Text]  
• Schomig, A., Kastrati, A., Dirschinger, J., Mehilli, J., Schricke, U., Pache, J., Martinoff, S., Neumann, F.-J., Schwaiger, M., The Stent versus Thrombolysis for Occluded Coronar, (2000). Coronary Stenting plus Platelet Glycoprotein IIb/IIIa Blockade Compared with Tissue Plasminogen Activator in Acute Myocardial Infarction. NEJM 343: 385-391 [Abstract] [Full Text]  
• Ophuis, A J O., Bar, F W, Vermeer, F, Janssen, W, Doevendans, P A, Haest, R J, Dassen, W R, Wellens, H J J (2000). Angiographic assessment of prospectively determined non-invasive reperfusion indices in acute myocardial infarction. Heart 84: 164-170 [Abstract] [Full Text]  
• Bar, F., Vainer, J., Stevenhagen, J., Neven, K., Aalbregt, R., Oude Ophuis, T., van Ommen, V., de Swart, H., de Muinck, E., Dassen, W., Wellens, H. (2000). Ten-year experience with early angioplasty in 759 patients with acute myocardial infarction. J Am Coll Cardiol 36: 51-58 [Abstract] [Full Text]  
• Wharton, T. P. Jr., Sinclair McNamara, N., Fedele, F. A., Jacobs, M. I., Gladstone, A. R., Funk, E. J. (2000). Reply. J Am Coll Cardiol 36: 301-303 [Full Text]  
• Cannon, C. P., Gibson, C. M., Lambrew, C. T., Shoultz, D. A., Levy, D., French, W. J., Gore, J. M., Weaver, W. D., Rogers, W. J., Tiefenbrunn, A. J. (2000). Relationship of Symptom-Onset-to-Balloon Time and Door-to-Balloon Time With Mortality in Patients Undergoing Angioplasty for Acute Myocardial Infarction. JAMA 283: 2941-2947 [Abstract] [Full Text]  
• Maillard, L., Hamon, M., Khalife, K., Steg, P. G., Beygui, F., Guermonprez, J.-L., Spaulding, C. M., Boulenc, J.-M., Lipiecki, J., Lafont, A., Brunel, P., Grollier, G., Koning, R., Coste, P., Favereau, X., Lancelin, B., Van Belle, E., Serruys, P., Monassier, J.-P., Raynaud, P., for the STENTIM-2 Investigators, (2000). A comparison of systematic stenting and conventional balloon angioplasty during primary percutaneous transluminal coronary angioplasty for acute myocardial infarction. J Am Coll Cardiol 35: 1729-1736 [Abstract] [Full Text]  
• Widimsky, P., Groch, L., Zelizko, M., Aschermann, M., Bednar, F., Suryapranata, H. (2000). Multicentre randomized trial comparing transport to primary angioplasty vs immediate thrombolysis vs combined strategy for patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory. The PRAGUE Study. Eur Heart J 21: 823-831 [Abstract]  
• Canto, J. G., Allison, J. J., Kiefe, C. I., Fincher, C., Farmer, R., Sekar, P., Person, S., Weissman, N. W. (2000). Relation of Race and Sex to the Use of Reperfusion Therapy in Medicare Beneficiaries with Acute Myocardial Infarction. NEJM 342: 1094-1100 [Abstract] [Full Text]  
• Whan Lee, C., Park, S.-W., Cho, G.-Y., Hong, M.-K., Kim, J.-J., Kang, D.-H., Song, J.-K., Lee, H.-J., Park, S.-J. (2000). Pressure-derived fractional collateral blood flow: a primary determinant of left ventricular recovery after reperfused acute myocardial infarction. J Am Coll Cardiol 35: 949-955 [Abstract] [Full Text]  
• Yano, M., Kojima, S., Sugi, T., Matsumoto, Y., Kuramochi, M., Yoshitomi, Y. (2000). Long-Term Follow-up of Primary Stenting with Coil Stent in Acute Myocardial Infarction. ANGIOLOGY 51: 107-114 [Abstract]