Graft-versus-host disease (GVHD) has been well documented inseveral recipients of liver transplants1,2,3,4,5,6,7,8. In thissyndrome alloreactive cells from the donor attack the recipient'sskin, gastrointestinal tissue, and hematopoietic tissue. Severemyelosuppression commonly results, but there has been a degreeof recovery of hematopoiesis in some patients after immunosuppressivetherapy. The recovery of hematopoiesis resulted from the recoveryof the recipient's bone marrow in some cases,1,3 but it alsocould be due to the proliferation of hematopoietic precursorcells in the donor's liver, since the liver is a site of hematopoiesisin fetuses and, under certain circumstances, in adults. . . . [Full Text of this Article]
Case Report
Methods
HLA Typing and Analysis of Restriction-Fragment-Length Polymorphisms
Analysis of Hematopoietic Progenitor Cells by Flow Cytometry and Cell Culture
Sex-Chromosome Analysis with Fluorescence in Situ Hybridization
Results
HLA Typing and RFLP Analysis
Sex-Chromosome Analysis of Differentiated Cells
Analysis of Hematopoietic Progenitor Cells
Discussion
Source Information
From Bone Marrow Transplantation Research (R.H.C., J.W.F.) and Immunology (A.N., M.J.S.), Charles A. Sammons Cancer Center, and Transplantation Services (G.K.), Baylor University Medical Center, Dallas; the Department of Hematopathology, University of Chicago, Chicago (J.A., J.F.); and Becton Dickinson Immunocytometry Systems, San Jose, Calif. (L.W.M.M.T.).
Address reprint requests to Dr. Collins at Bone Marrow Transplantation Research, Baylor University Medical Center, Sammons Tower, Suite 410, 3409 Worth St., Dallas, TX 75246.
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