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Previous Volume 328:766-770 March 18, 1993 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Graft-versus-host disease (GVHD) is a well-known complication of allogeneic bone marrow transplantation and is increasingly being recognized after solid-organ transplantation and transfusion^1,2,3. Like GVHD occurring after bone marrow transplantation, transfusion-associated GVHD is characterized by fever, skin rash, diarrhea, and hepatitis. However, transfusion-associated GVHD typically occurs much sooner (median, 10 to 12 days after transfusion), is frequently associated with bone marrow aplasia, usually does not respond to immunosuppressive therapy, and is fatal in most cases^{4,5,6,7,8,9,10}. Since gamma irradiation of cellular blood components before transfusion can prevent the development of transfusion-associated GVHD, it is critical to identify susceptible hosts.

The . . . [Full Text of this Article]

Case Report

Results

Pathological Findings

HLA Typing

Discussion

Source Information

From the Divisions of Medical Oncology (R.A.S., F.G.H.), Immunogenetics (E.J.K.), and Tumor Immunology (K.C.A.), Dana-Farber Cancer Institute, Boston; the Division of Dermatology, New England Deaconess Hospital, Boston (J.S.D.); the Department of Medicine, Harvard Medical School, Boston (R.A.S., F.G.H., J.S.D., K.C.A.); and the American Red Cross Blood Services, Greater Upstate New York Region, Syracuse (N.L.D.). Presented in abstract form at the American Society of Hematology Annual Meeting, December 4-8, 1992, Anaheim, California.

Address reprint requests to Dr. Anderson at the Division of Tumor Immunology, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115.

References

Related Letters:

Graft-versus-Host Disease
Petz L. D., Anderson K. C., Shivdasani R. A.
Extract | Full Text  
N Engl J Med 1993; 329:664-665, Aug 26, 1993. Correspondence

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