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Previous Volume 328:861-868 March 25, 1993 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In 1959, not long after surfactant had been identified as critical to maintaining lung inflation at low transpulmonary pressures,^1,2 Avery and Mead³ reported that saline extracts from the lungs of preterm infants with respiratory distress syndrome lacked the low surface tension characteristic of pulmonary surfactant. After several unsuccessful attempts to treat infants with respiratory distress syndrome with aerosolized surfactant,^4,5 intratracheal administration of surfactant recovered from the air spaces of mature animal lungs was found to improve lung expansion and ventilation in preterm animals^6,7,8. The clinical potential of surfactant treatment for respiratory distress syndrome was demonstrated by Fujiwara et al.⁹ . . . [Full Text of this Article]

Natural Surfactant and the Surfactants in Clinical Use

Clinical Trials

Timing of Surfactant Treatment

Repetition of Treatment

Acute Effects of Surfactants on the Lung

Pharmacokinetics of Surfactant

Clinical Implications

Source Information

From the Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, Calif., and the UCLA School of Medicine, Los Angeles.

Address reprint requests to Dr. Jobe at the Department of Pediatrics, Harbor-UCLA Medical Center, 1000 W. Carson Street, RB-1, Torrance, CA 90509.

References

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