Our understanding of glaucoma has undergone dramatic changesin the past decade. The ferment has derived from new epidemiologicinformation, improved diagnostic methods, and developments insurgical and drug therapy. This review concentrates on primaryopen-angle glaucoma, the most prevalent form of the disorderin Western countries.
Definition
Primary open-angle glaucoma usually affects both eyes and combinesa particular abnormal appearance of the optic disk (optic-nervehead) with a slowly progressive loss of visual sensitivity (Figure 1).The characteristic appearance of the glaucomatous opticdisk is visible by ophthalmoscopy (Figure 2). The present standardfor determining visual . . . [Full Text of this Article]
Abnormality of the Optic Disk
Loss of Visual Field
Epidemiologic Features
Prevalence
Risk Factors
Pathophysiologic Features
The Role of Connective Tissues in the Optic Disk
The Role of Vascular Function in the Optic Disk
The Role of the Trabecular Meshwork
Diagnosis
Tonometry
Gonioscopy
Examination of the Optic Disk and Nerve-Fiber Layer
Visual-Field Testing
Treatment
The Target of Treatment
Medical Treatment
Laser Treatment
Surgery
Secondary Surgical Options
Adjunctive Therapy
Expectations of Therapy
Source Information
From the Glaucoma Service and the Dana Center for Preventive Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore.
Address reprint requests to Dr. Quigley at Wilmer 120, Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21205.
Joachim, S. C., Grus, F. H., Kraft, D., White-Farrar, K., Barnes, G., Barbeck, M., Ghanaati, S., Cao, S., Li, B., Wax, M. B.
(2009). Complex Antibody Profile Changes in an Experimental Autoimmune Glaucoma Animal Model. IOVS
50: 4734-4742
[Abstract][Full Text]
Ren, R., Wang, N., Li, B., Li, L., Gao, F., Xu, X., Jonas, J. B.
(2009). Lamina Cribrosa and Peripapillary Sclera Histomorphometry in Normal and Advanced Glaucomatous Chinese Eyes with Various Axial Length. IOVS
50: 2175-2184
[Abstract][Full Text]
Yu, A. L., Fuchshofer, R., Birke, M., Kampik, A., Bloemendal, H., Welge-Lussen, U.
(2008). Oxidative Stress and TGF-{beta}2 Increase Heat Shock Protein 27 Expression in Human Optic Nerve Head Astrocytes. IOVS
49: 5403-5411
[Abstract][Full Text]
Aga, M., Bradley, J. M., Keller, K. E., Kelley, M. J., Acott, T. S.
(2008). Specialized Podosome- or Invadopodia-like Structures (PILS) for Focal Trabecular Meshwork Extracellular Matrix Turnover. IOVS
49: 5353-5365
[Abstract][Full Text]
Wax, M. B., Tezel, G., Yang, J., Peng, G., Patil, R. V., Agarwal, N., Sappington, R. M., Calkins, D. J.
(2008). Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cell Neurons via Activated T-Cell-Derived Fas-Ligand. J. Neurosci.
28: 12085-12096
[Abstract][Full Text]
Shibuya, E., Meguro, A., Ota, M., Kashiwagi, K., Mabuchi, F., Iijima, H., Kawase, K., Yamamoto, T., Nakamura, M., Negi, A., Sagara, T., Nishida, T., Inatani, M., Tanihara, H., Aihara, M., Araie, M., Fukuchi, T., Abe, H., Higashide, T., Sugiyama, K., Kanamoto, T., Kiuchi, Y., Iwase, A., Ohno, S., Inoko, H., Mizuki, N.
(2008). Association of Toll-like Receptor 4 Gene Polymorphisms with Normal Tension Glaucoma. IOVS
49: 4453-4457
[Abstract][Full Text]
Weber, A. J., Harman, C. D., Viswanathan, S.
(2008). Effects of optic nerve injury, glaucoma, and neuroprotection on the survival, structure, and function of ganglion cells in the mammalian retina. J. Physiol.
586: 4393-4400
[Abstract][Full Text]
Weber, A. J., Harman, C. D.
(2008). BDNF Preserves the Dendritic Morphology of {alpha} and {beta} Ganglion Cells in the Cat Retina after Optic Nerve Injury. IOVS
49: 2456-2463
[Abstract][Full Text]
Fernandez-Durango, R., Fernandez-Martinez, A., Garcia-Feijoo, J., Castillo, A., de la Casa, J. M., Garcia-Bueno, B., Perez-Nievas, B. G., Fernandez-Cruz, A., Leza, J. C.
(2008). Expression of Nitrotyrosine and Oxidative Consequences in the Trabecular Meshwork of Patients with Primary Open-Angle Glaucoma. IOVS
49: 2506-2511
[Abstract][Full Text]
He, Y., Leung, K. W., Zhang, Y.-H., Duan, S., Zhong, X.-F., Jiang, R.-Z., Peng, Z., Tombran-Tink, J., Ge, J.
(2008). Mitochondrial Complex I Defect Induces ROS Release and Degeneration in Trabecular Meshwork Cells of POAG Patients: Protection by Antioxidants. IOVS
49: 1447-1458
[Abstract][Full Text]
Kiekens, S., Veva De Groot, , Coeckelbergh, T., Tassignon, M.-J., van de Heyning, P., Wilfried De Backer, , Verbraecken, J.
(2008). Continuous Positive Airway Pressure Therapy Is Associated with an Increase in Intraocular Pressure in Obstructive Sleep Apnea. IOVS
49: 934-940
[Abstract][Full Text]
Saleh, M., Nagaraju, M., Porciatti, V.
(2007). Longitudinal Evaluation of Retinal Ganglion Cell Function and IOP in the DBA/2J Mouse Model of Glaucoma. IOVS
48: 4564-4572
[Abstract][Full Text]
Kelley, M. J., Rose, A. Y., Song, K., Chen, Y., Bradley, J. M., Rookhuizen, D., Acott, T. S.
(2007). Synergism of TNF and IL-1 in the Induction of Matrix Metalloproteinase-3 in Trabecular Meshwork. IOVS
48: 2634-2643
[Abstract][Full Text]
Harwerth, R. S., Vilupuru, A. S., Rangaswamy, N. V., Smith, E. L. III
(2007). The Relationship between Nerve Fiber Layer and Perimetry Measurements. IOVS
48: 763-773
[Abstract][Full Text]
Sharif, N. A., Kelly, C. R., McLaughlin, M.
(2006). Human Trabecular Meshwork Cells Express Functional Serotonin-2A (5HT2A) Receptors: Role in IOP Reduction.. IOVS
47: 4001-4010
[Abstract][Full Text]
De Marco, N., Buono, M., Troise, F., Diez-Roux, G.
(2006). Optineurin Increases Cell Survival and Translocates to the Nucleus in a Rab8-dependent Manner upon an Apoptotic Stimulus. J. Biol. Chem.
281: 16147-16156
[Abstract][Full Text]
Harwerth, R. S., Quigley, H. A.
(2006). Visual field defects and retinal ganglion cell losses in patients with glaucoma.. Arch Ophthalmol
124: 853-859
[Abstract][Full Text]
Hosseini, M., Rose, A. Y., Song, K., Bohan, C., Alexander, J. P., Kelley, M. J., Acott, T. S.
(2006). IL-1 and TNF Induction of Matrix Metalloproteinase-3 by c-Jun N-Terminal Kinase in Trabecular Meshwork.. IOVS
47: 1469-1476
[Abstract][Full Text]
Knox, F A, Barry, M, McGowan, B, O'Brien, C
(2006). The rising cost of glaucoma drugs in Ireland 1996-2003. Br J Ophthalmol
90: 162-165
[Abstract][Full Text]
Lamoureux, E. L., Lo, K., Ferraro, J. G., Constantinou, M., Keeffe, J. E., Muller, A., Taylor, H. R.
(2006). The Agreement between the Heidelberg Retina Tomograph and a Digital Nonmydriatic Retinal Camera in Assessing Area Cup-to-Disc Ratio. IOVS
47: 93-98
[Abstract][Full Text]
Zhang, M., Rao, P. V.
(2005). Blebbistatin, a Novel Inhibitor of Myosin II ATPase Activity, Increases Aqueous Humor Outflow Facility in Perfused Enucleated Porcine Eyes. IOVS
46: 4130-4138
[Abstract][Full Text]
Weber, A. J., Harman, C. D.
(2005). Structure-Function Relations of Parasol Cells in the Normal and Glaucomatous Primate Retina. IOVS
46: 3197-3207
[Abstract][Full Text]
Vittal, V., Rose, A., Gregory, K. E., Kelley, M. J., Acott, T. S.
(2005). Changes in Gene Expression by Trabecular Meshwork Cells in Response to Mechanical Stretching. IOVS
46: 2857-2868
[Abstract][Full Text]
Pang, I.-H., Johnson, E. C., Jia, L., Cepurna, W. O., Shepard, A. R., Hellberg, M. R., Clark, A. F., Morrison, J. C.
(2005). Evaluation of Inducible Nitric Oxide Synthase in Glaucomatous Optic Neuropathy and Pressure-Induced Optic Nerve Damage. IOVS
46: 1313-1321
[Abstract][Full Text]
Fleming, C., Whitlock, E. P., Beil, T., Smit, B., Harris, R. P.
(2005). Screening for Primary Open-Angle Glaucoma in the Primary Care Setting: An Update for the US Preventive Services Task Force. Ann Fam Med
3: 167-170
[Abstract][Full Text]
Chan, A Y K, Liu, D T L, Allanore, Y, Kahan, A, Brezin, A
(2005). Increased prevalence of ocular glaucomatous abnormalities in systemic sclerosis * Authors' reply. Ann Rheum Dis
64: 341-342
[Full Text]
Liton, P. B., Liu, X., Stamer, W. D., Challa, P., Epstein, D. L., Gonzalez, P.
(2005). Specific Targeting of Gene Expression to a Subset of Human Trabecular Meshwork Cells Using the Chitinase 3-Like 1 Promoter. IOVS
46: 183-190
[Abstract][Full Text]
Allanore, Y, Parc, C, Monnet, D, Brezin, A P, Kahan, A
(2004). Increased prevalence of ocular glaucomatous abnormalities in systemic sclerosis. Ann Rheum Dis
63: 1276-1278
[Abstract][Full Text]
Harwerth, R. S., Carter-Dawson, L., Smith, E. L. III, Barnes, G., Holt, W. F., Crawford, M. L. J.
(2004). Neural Losses Correlated with Visual Losses in Clinical Perimetry. IOVS
45: 3152-3160
[Abstract][Full Text]
Melki, R, Colomb, E, Lefort, N, Brezin, A P, Garchon, H-J
(2004). CYP1B1 mutations in French patients with early-onset primary open-angle glaucoma. J. Med. Genet.
41: 647-651
[Abstract][Full Text]
Swanson, W. H., Felius, J., Pan, F.
(2004). Perimetric Defects and Ganglion Cell Damage: Interpreting Linear Relations Using a Two-Stage Neural Model. IOVS
45: 466-472
[Abstract][Full Text]
Conley, S. M., Bruhn, R. L., Morgan, P. V., Stamer, W. D.
(2004). Selenium's Effects on MMP-2 and TIMP-1 Secretion by Human Trabecular Meshwork Cells. IOVS
45: 473-479
[Abstract][Full Text]
Bradley, J. M. B., Kelley, M. J., Rose, A., Acott, T. S.
(2003). Signaling Pathways Used in Trabecular Matrix Metalloproteinase Response to Mechanical Stretch. IOVS
44: 5174-5181
[Abstract][Full Text]
Kang, J. H., Pasquale, L. R., Rosner, B. A., Willett, W. C., Egan, K. M., Faberowski, N., Hankinson, S. E.
(2003). Prospective Study of Cigarette Smoking and the Risk of Primary Open-angle Glaucoma. Arch Ophthalmol
121: 1762-1768
[Abstract][Full Text]
Melki, R, Belmouden, A, Akhayat, O, Brezin, A, Garchon, H-J
(2003). The M98K variant of the OPTINEURIN (OPTN) gene modifies initial intraocular pressure in patients with primary open angle glaucoma. J. Med. Genet.
40: 842-844
[Full Text]
Kroese, M, Burton, H
(2003). Primary open angle glaucoma. The need for a consensus case definition. J. Epidemiol. Community Health
57: 752-754
[Abstract][Full Text]
Kang, J. H., Pasquale, L. R., Willett, W., Rosner, B., Egan, K. M., Faberowski, N., Hankinson, S. E.
(2003). Antioxidant Intake and Primary Open-Angle Glaucoma: A Prospective Study. Am J Epidemiol
158: 337-346
[Abstract][Full Text]
Mizuno, K., Koide, T., Saito, N., Fujii, M., Nagahara, M., Tomidokoro, A., Tamaki, Y., Araie, M.
(2002). Topical Nipradilol: Effects on Optic Nerve Head Circulation in Humans and Periocular Distribution in Monkeys. IOVS
43: 3243-3250
[Abstract][Full Text]
Levkovitch-Verbin, H., Quigley, H. A., Martin, K. R. G., Valenta, D., Baumrind, L. A., Pease, M. E.
(2002). Translimbal Laser Photocoagulation to the Trabecular Meshwork as a Model of Glaucoma in Rats. IOVS
43: 402-410
[Abstract][Full Text]
Sato, T., Roy, S.
(2002). Effect of High Glucose on Fibronectin Expression and Cell Proliferation in Trabecular Meshwork Cells. IOVS
43: 170-175
[Abstract][Full Text]
Bradley, J. M. B., Kelley, M. J., Zhu, X., Anderssohn, A. M., Alexander, J. P., Acott, T. S.
(2001). Effects of Mechanical Stretching on Trabecular Matrix Metalloproteinases. IOVS
42: 1505-1513
[Abstract][Full Text]
Mizuno, K., Koide, T., Yoshimura, M., Araie, M.
(2001). Neuroprotective Effect and Intraocular Penetration of Nipradilol, a {beta}-Blocker with Nitric Oxide Donative Action. IOVS
42: 688-694
[Abstract][Full Text]
Honjo, M., Tanihara, H., Inatani, M., Kido, N., Sawamura, T., Yue, B. Y. J. T., Narumiya, S., Honda, Y.
(2001). Effects of Rho-Associated Protein Kinase Inhibitor Y-27632 on Intraocular Pressure and Outflow Facility. IOVS
42: 137-144
[Abstract][Full Text]
Swindale, N. V., Stjepanovic, G., Chin, A., Mikelberg, F. S.
(2000). Automated Analysis of Normal and Glaucomatous Optic Nerve Head Topography Images. IOVS
41: 1730-1742
[Abstract][Full Text]
Wiggs, J. L., Allingham, R. R., Hossain, A., Kern, J., Auguste, J., DelBono, E. A., Broomer, B., Graham, F. L., Hauser, M., Pericak-Vance, M., Haines, J. L.
(2000). Genome-wide scan for adult onset primary open angle glaucoma. Hum Mol Genet
9: 1109-1117
[Abstract][Full Text]
Gonzalez, P., Epstein, D. L., Borrás, T.
(2000). Genes Upregulated in the Human Trabecular Meshwork in Response to Elevated Intraocular Pressure. IOVS
41: 352-361
[Abstract][Full Text]
Bradley, J. M. B., Anderssohn, A. M., Colvis, C. M., Parshley, D. E., Zhu, X., Ruddat, M. S., Samples, J. R., Acott, T. S.
(2000). Mediation of Laser Trabeculoplasty-Induced Matrix Metalloproteinase Expression by IL-1{beta} and TNF{alpha}. IOVS
41: 422-430
[Abstract][Full Text]
Harwerth, R. S., Carter-Dawson, L., Shen, F., Smith, E. L. III, Crawford, M. L. J.
(1999). Ganglion Cell Losses Underlying Visual Field Defects from Experimental Glaucoma. IOVS
40: 2242-2250
[Abstract][Full Text]
Sharif, N A, Xu, S X
(1999). Human retina contains polyamine sensitive [3H]-ifenprodil binding sites: implications for neuroprotection?. Br J Ophthalmol
83: 236-240
[Abstract][Full Text]
Angius, A., De Gioia, E., Loi, A., Fossarello, M., Sole, G., Orzalesi, N., Grignolo, F., Cao, A., Pirastu, M.
(1998). A Novel Mutation in the GLC1A Gene Causes Juvenile Open-angle Glaucoma in 4 Families From the Italian Region of Puglia. Arch Ophthalmol
116: 793-797
[Abstract][Full Text]
Quigley, H. A.
(1998). The Search for Glaucoma Genes -- Implications for Pathogenesis and Disease Detection. NEJM
338: 1062-1064
[Full Text]
BUCKLEY, C. H, HADOKE, P. W F, O'BRIEN, C. J
(1997). Use of isolated ocular arteries in vitro to define the pathology of vascular changes in glaucoma. Br J Ophthalmol
81: 599-607
[Full Text]
Garbe, E., Suissa, S., LeLorier, J.
(1997). Glucocorticoid Use and Risks of Ocular Hypertension and Glaucoma-Reply. JAMA
277: 1930-1930
[Abstract]
Bylund, D. B., Iversen, L. J., Matulka, W. J., Chacko, D. M.
(1997). . J. Pharmacol. Exp. Ther.
281: 1171-1177
[Abstract][Full Text]
(1997). The management of primary open angle glaucoma. DTB
35: 4-6
[Abstract][Full Text]
Rossetti, L., Orzalesi, N., Liberati, A., Scorpiglione, N.
(1994). Randomized Clinical Trials on Medical Treatment of Glaucoma: Are They Appropriate to Guide Clinical Practice?-Reply. Arch Ophthalmol
112: 727-728
[Abstract]
Rossetti, L., Orzalesi, N., Liberati, A., Quigley, H. A.
(1993). The Medical Treatment of Open-Angle Glaucoma. NEJM
329: 735-736
[Full Text]