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Previous Volume 328:1126-1127 April 15, 1993 Number 15 Next

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To the Editor: Adrenoleukodystrophy is a sex-linked disorder in which very-long-chain fatty acids accumulate in all body tissues¹. For this reason, a variety of diets have been formulated to lower the levels of these acids. One diet includes Lorenzo's Oil, a product that contains 20 percent erucic acid (22:1) and 80 percent oleic acid (18:1). During the past two years, 40 male and 6 female patients have received Lorenzo's Oil according to a protocol calculated to provide 20 percent of daily caloric intake. In 19 of these patients the platelet count has decreased significantly (Table 1).

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• Hufford, D. J. (2003). Evaluating Complementary and Alternative Medicine: The Limits of Science and of Scientists. J Law Med Ethics 31: 198-212  
• van Geel, B M, Assies, J, Haverkort, E B, Koelman, J H T M, Verbeeten, B Jr, Wanders, R J A, Barth, P G (1999). Progression of abnormalities in adrenomyeloneuropathy and neurologically asymptomatic X-linked adrenoleukodystrophy despite treatment with "Lorenzo's oil". J. Neurol. Neurosurg. Psychiatry 67: 290-299 [Abstract] [Full Text]  
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