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Previous Volume 328:1173-1182 April 22, 1993 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although retroviruses were among the earliest viruses discovered,^1,2 they were linked to human disease only in the early 1980s,^3,4,5 with the study of T-cell lines from patients with the lymphoproliferative disorder adult T-cell leukemia⁶. T cells from these patients were shown to release a retrovirus, later known as human T-cell lymphotropic virus type I (HTLV-I), the first member of a new class of human viruses⁷. This led to the investigation of a number of idiopathic disorders. In 1985, tropical spastic paraparesis, an endemic disease in the West Indies,⁸ was associated with immune reactivity to HTLV-I in serum⁹. . . . [Full Text of this Article]

Structure of HTLV-I

Epidemiology

Clinical Features of Adult T-Cell Leukemia

Clinical Features of HTLV-I Myelopathy

Other Diseases Associated with HTLV-I

HTLV-I Infection of T Cells

HTLV-I-Induced Cytokines

Humoral Immune Response to HTLV-I

Cellular Immune Response

Mechanisms of HTLV-I-Induced Diseases

HTLV-I Myelopathy

Adult T-Cell Leukemia

Treatment

Discussion

Source Information

From the Center for Neurologic Diseases, Division of Neurology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston.

Address reprint requests to Dr. Hafler at the Center for Neurologic Diseases, 221 Longwood Ave., Boston, MA 02115.

References

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