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Editorial
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Volume 328:1192-1193 April 22, 1993 Number 16
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A Tale of Two Mutants

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The primary infection of a host with the human immunodeficiency virus (HIV) is characterized by fever, pharyngitis, myalgia, lymphadenopathy, maculopapular rash, oral ulcers, and less frequently, aseptic meningitis1. About three to six weeks after a sexual encounter with or exposure to blood from an HIV-infected person, an initial lymphocytopenia of both CD4 and CD8 cells occurs coincidentally with a profound viremia. Over a period of one week to three months, symptoms, viral antigenemia, and culturable virus decrease spontaneously to undetectable levels, sometimes precipitously, sometimes slowly, but concomitantly with the humoral response to viral antigens. After the lymphocytopenia, relative or . . . [Full Text of this Article]

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