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Previous Volume 328:1352-1354 May 6, 1993 Number 18 Next

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To the Editor: Further clarification of the methods and recognition of potential biases would assist in interpretation of the report of patients with central nervous system toxoplasmosis by Porter and Sande (Dec. 3 issue).¹ In their study, "a patient was considered to have toxoplasmosis if there was histologic proof of central nervous system infection at either biopsy or autopsy, in addition to the appearance of brain lesions on CT [computed tomography] or MRI [magnetic resonance imaging] consistent with a diagnosis of toxoplasmosis that improved after specific treatment." However, it appears that only 29 patients had histologic proof of infection. Therefore . . . [Full Text of this Article]

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