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Previous Volume 328:1355-1357 May 6, 1993 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: I was rather confused by the article by Smith et al. (Dec. 10 issue)¹ and the related editorial by Rowland². The authors suggest that high-titer antibodies to human motor-neuron voltage-gated calcium channels (VGCCs) present in patients with amyotrophic lateral sclerosis (ALS) cross-react with rabbit L-type VGCC epitopes. Skeletal-muscle L-type channels show only 15 to 45 percent homology with extracellular domains of neuronal L-type channels, and thus high titers are more likely to suggest a reaction to a primary muscle antigen³.

The assay used for L-type VGCCs is novel in that it relies on a sandwich . . . [Full Text of this Article]

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