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Previous Volume 328:106-113 January 14, 1993 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The interleukin-1 family consists of three structurally related polypeptides. The first two are interleukin-1 and interleukin-1, each of which has a broad spectrum of both beneficial and harmful biologic actions, and the third is interleukin-1-receptor antagonist, which inhibits the activities of interleukin-1. Among the properties of the two forms of interleukin-1 ( and ) is the ability to induce fever, sleep, anorexia, and hypotension. Interleukin-1 stimulates the release of pituitary hormones, increases the synthesis of collagenases, resulting in the destruction of cartilage, and stimulates the production of prostaglandins, leading to a decrease in the pain threshold. Interleukin-1 has also . . . [Full Text of this Article]

Interleukin-1 and Interleukin-1

Structure, Synthesis, Processing, and Secretion

Role in Normal Physiology

Interleukin-1 as a Mediator of Disease

Inhibition of Interleukin-1 Production and Action

Inhibition of the Synthesis or Processing of Interleukin-1

Neutralization of Interleukin-1 Activity

Blockade of Interleukin-1 Receptors

Role of Interleukin-1 in Disease

Sepsis Syndrome

Rheumatoid Arthritis

Inflammatory Bowel Disease

Acute and Chronic Myelogenous Leukemia

Insulin-Dependent Diabetes Mellitus

Atherosclerosis

Other Diseases

Possible Imbalance between Interleukin-1 and Interleukin-1 Antagonists

Differential Regulation of Production of Interleukin-1 and Interleukin-1-Receptor Antagonist

Does Blocking the Action of Interleukin-1 Impair Host Defense Mechanisms?

Conclusions

Source Information

From the Departments of Medicine, Tufts University School of Medicine and New England Medical Center, Boston.

Address reprint requests to Dr. Dinarello at the Department of Medicine, New England Medical Center, 750 Washington St., Boston, MA 02111.

References

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