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Previous Volume 328:114-120 January 14, 1993 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Serious birth defects, often genetically determined, complicate and threaten the lives of 3 percent of newborn infants¹. These disorders account for 20 percent of deaths during the newborn period and an even higher percentage of serious morbidity in infancy and childhood². The cost of neonatal intensive care is staggering. Higher still are the costs of rehabilitation programs for the severely handicapped. The family tragedy is immeasurable. With the growing recognition of the frequency and importance of congenital disorders and with current social trends toward smaller families and delays in childbearing, prenatal diagnosis has an important role in the . . . [Full Text of this Article]

Indications for Prenatal Diagnosis

General Risk Factors

Specific Risk Factors

Ethnic and Racial Risk Factors

Procedures

Amniocentesis

Chorionic-Villus Sampling

Early Amniocentesis

Percutaneous Umbilical Blood Sampling

Fetal Biopsy

Ultrasonography

Efficacy

The Future

Source Information

From the Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston.

Address reprint requests to Dr. D'Alton at the Department of Obstetrics and Gynecology, New England Medical Center, 750 Washington St., Box 324, Boston, MA 02111.

References

Related Letters:

Prenatal Diagnosis
Reynolds T.M., Penney M.D., Feudtner C., Minnick M. A., Fletcher J. C., Wertz D. C., D'Alton M. E., DeCherney A. H.
Extract | Full Text  
N Engl J Med 1993; 328:1710-1712, Jun 10, 1993. Correspondence

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