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Previous Volume 328:1457-1460 May 20, 1993 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Endotoxin, a lipopolysaccharide component of the outer membrane of gram-negative bacteria, is involved in the pathogenesis of septic shock, but it is unclear whether endotoxin alone is capable of causing all the manifestations of the septic shock syndrome. In animals, endotoxin causes many of the clinical features¹ but produces a low-cardiac-output form of shock that is unlike the hyperdynamic cardiovascular profile of septic shock in humans^2,3. In humans, the administration of endotoxin (4 ng per kilogram of body weight) triggers the release of cytokines,⁴ activates the coagulation and fibrinolytic systems,^5,6 and causes a decrease in systemic vascular resistance and . . . [Full Text of this Article]

Case Report

Methods

Results

Discussion

Source Information

From the Division of Pulmonary and Critical Care Medicine (A.M.T.S., F.S.C.) and the Department of Medicine (H.C.K., D.R.L.), Georgetown University, Washington, D.C., and the Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Md. (A.F.S., R.L.D.).

Address reprint requests to Dr. Taveira da Silva at the Division of Pulmonary and Critical Care Medicine, Georgetown University Hospital, 3800 Reservoir Rd., NW, Washington, DC 20007.

References

Related Letters:

Self-Administration of Salmonella Endotoxin
Stern R., Hurley J. C., da Silva A. M. T., Suffredini A. F., Danner R. L.
Extract | Full Text  
N Engl J Med 1993; 329:1426-1427, Nov 4, 1993. Correspondence

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