One of the most frequent and serious problems confronting cliniciansis the management of a serious infection and the systemic responseto infection, a syndrome termed sepsis. When this syndrome resultsin hypotension and organ dysfunction, it is called septic shock.Septic shock is the most common cause of death in intensivecare units,1 and it is the 13th most common cause of death inthe United States2. The incidence of the two disorders continuesto rise: 400,000 cases of sepsis and 200,000 episodes of septicshock are estimated to occur annually, resulting in more than100,000 deaths1.
From the Section of Critical Care Medicine and the Section of Cardiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, where reprint requests should be addressed to Dr. Parrillo.
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Zaedi, S., Jesmin, S., Maeda, S., Shimojo, N., Yamaguchi, I., Goto, K., Miyauchi, T.
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(2006). MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. JEM
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Kumar, A., Kumar, A., Michael, P., Brabant, D., Parissenti, A. M., Ramana, C. V., Xu, X., Parrillo, J. E.
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280: 42619-42626
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(2005). Bedside Ultrasonography in the ICU: Part 1. Chest
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Brueckmann, M., Huhle, G., Lang, S., Haase, K. K., Bertsch, T., Weiss, C., Kaden, J. J., Putensen, C., Borggrefe, M., Hoffmann, U.
(2005). Prognostic Value of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients With Severe Sepsis. Circulation
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Williams, G. J., Breazeale, S. D., Raetz, C. R. H., Naismith, J. H.
(2005). Structure and Function of Both Domains of ArnA, a Dual Function Decarboxylase and a Formyltransferase, Involved in 4-Amino-4-deoxy-L-arabinose Biosynthesis. J. Biol. Chem.
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Molor-Erdene, P., Okajima, K., Isobe, H., Uchiba, M., Harada, N., Okabe, H.
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(2004). PI3K-Akt Pathway Suppresses Coagulation and Inflammation in Endotoxemic Mice. Arterioscler. Thromb. Vasc. Bio.
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