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Correspondence
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Volume 328:1498-1499 May 20, 1993 Number 20
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High-Dose Erythropoietin for Unstable Hemoglobin Burke in a Patient Receiving Hemodialysis

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 by Rodgers, G. P.
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To the Editor: Rodgers et al. (Jan. 14 issue)1 report the use of erythropoietin to induce the fetal-hemoglobin response in patients with sickle cell disease (hemoglobin S: {beta}6 Glu-to-Val) under treatment with hydroxyurea. We report an increased level of fetal hemoglobin in a patient with hemoglobin Burke ({beta}107 Gly-to-Arg) undergoing hemodialysis who received a huge dose of erythropoietin alone.

A 66-year-old Japanese man receiving hemodialysis had severe anemia that necessitated multiple transfusions of up to 1600 ml of blood per month. Pretreatment hematologic data are shown in Table 1. An undetectable serum level of haptoglobin, an increased level . . . [Full Text of this Article]

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