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Correspondence
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Volume 328:1500-1501 May 20, 1993 Number 20
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State-by-State Pharmaceutical Formulations?

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To the Editor: In November 1992, Whitehall Laboratories replaced the inactive preservative ingredient phenylmercuric nitrate in some stocks of Preparation H suppositories, ointment, and cream. Reformulation was dictated not by new scientific evidence but by the need to conform to California's Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65)1. The new formulations will contain nonmercurial preservatives and will be available only in states receiving merchandise from the company's western regional distribution center.

This minimal reformulation is highly important, because nationally distributed medication is being modified to meet the regulatory requirements of a single state.

Phenylmercuric nitrate, . . . [Full Text of this Article]

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