FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 328:1538-1541 May 27, 1993 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Hereditary nephrogenic diabetes insipidus is a rare, X-linked disorder manifested by an inability to concentrate the urine despite high plasma concentrations of arginine vasopressin or the administration of large doses of vasopressin or its analogues^1,2. Affected males have profound hyposmotic polyuria soon after birth, often leading to recurrent episodes of severe dehydration. Unless recognized and treated early, these episodes may lead to failure to thrive, growth retardation, repeated bouts of cerebral edema with resultant mental retardation, or death. Females who are carriers of the gene for the disease have symptoms that range from a defective urinary-concentrating ability demonstrable only . . . [Full Text of this Article]

Methods

Patients

DNA Preparation and Analysis

Results

Discussion

Source Information

From the Molecular Pathophysiology Branch, National Institute of Diabetes, Digestive and Kidney Diseases (J.J.M., A.M.S.), and the Laboratory of Cell Biology, National Institute of Mental Health (A.-M.O., M.J.B., S.J.L.), National Institutes of Health, Bethesda, Md., and the Children's Service, Massachusetts General Hospital, Boston (J.D.C.).

Address reprint requests to Dr. Merendino at the National Institutes of Health, Bldg. 10, Rm. 8C-101, Bethesda, MD 20892.

References

This article has been cited by other articles:

• Morris, A. J., Malbon, C. C. (1999). Physiological Regulation of G Protein-Linked Signaling. Physiol. Rev. 79: 1373-1430 [Abstract] [Full Text]  
• Stavrou, S. S., Zhu, Y.-S., Cai, L.-Q., Katz, M. D., Herrera, C., DeFillo-Ricart, M., Imperato-McGinley, J. (1998). A Novel Mutation of the Human Luteinizing Hormone Receptor in 46XY and 46XX Sisters. J. Clin. Endocrinol. Metab. 83: 2091-2098 [Abstract] [Full Text]  
• Gagliardi, P. C., Bernasconi, S., Repaske, D. R. (1997). Autosomal Dominant Neurohypophyseal Diabetes Insipidus Associated with a Missense Mutation Encoding Gly23->Val in Neurophysin II. J. Clin. Endocrinol. Metab. 82: 3643-3646 [Abstract] [Full Text]  
• Latronico, A. C., Anasti, J., Arnhold, I. J.P., Rapaport, R., Mendonca, B. B., Bloise, W., Castro, M., Tsigos, C., Chrousos, G. P. (1996). Testicular and Ovarian Resistance to Luteinizing Hormone Caused by Inactivating Mutations of the Luteinizing Hormone-Receptor Gene. NEJM 334: 507-512 [Full Text]  
• Childs, B. (1995). Nephrogenic Diabetes Insipidus: A Personal Perspective. Arch Pediatr Adolesc Med 149: 181-186 [Abstract]  
• Lightman, S. L. (1993). Molecular Insights into Diabetes Insipidus. NEJM 328: 1562-1563 [Full Text]