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Previous Volume 328:1562-1563 May 27, 1993 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The maintenance of plasma osmolality within a remarkably narrow range is achieved by very sensitive mechanisms that regulate thirst and the release of the antidiuretic hormone arginine vasopressin from the posterior pituitary gland. Vasopressin reduces the renal excretion of water by increasing the permeability of the collecting-duct epithelium to water.

Vasopressin acts at the tissue level by binding to specific receptors that are coupled to G proteins. There are two well-characterized types of vasopressin receptors: V2 receptors, which are coupled to adenylate cyclase, and V1 receptors, which activate the hydrolysis of phosphatidylinositol, leading to the mobilization of intracellular calcium. The . . . [Full Text of this Article]

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