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Previous Volume 328:1639-1641 June 3, 1993 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their comprehensive review of asthma, McFadden and Gilbert (Dec. 31 issue)¹ appropriately question published epidemiologic data suggesting that all asthma is related to atopy. There is increasing evidence of immunologic differences between allergic and intrinsic, or nonatopic, asthma. Apart from higher eosinophil counts in peripheral blood,² comparisons of persons with allergic and intrinsic asthma have found differences in the expression of activation markers on T-lymphocyte subgroups and in the profiles of cytokines in bronchoalveolar-lavage fluid³.

We question the authors' statements about the role of interleukin-2 in allergic asthma. None of the cited papers have in . . . [Full Text of this Article]

References

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• Gaspar Elsas, M. I. C., Joseph, D., Xavier Elsas, P., Boris Vargaftig, B. (1997). Rapid Increase in Bone-marrow Eosinophil Production and Responses to Eosinopoietic Interleukins Triggered by Intranasal Allergen Challenge. Am. J. Respir. Cell Mol. Bio. 17: 404-413 [Abstract] [Full Text]