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Images in Clinical Medicine
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Volume 328:1675 June 10, 1993 Number 23
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Zidovudine Myopathy

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Figure 1


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Figure 1. Zidovudine Myopathy.

A muscle-biopsy specimen from a 33-year-old man who had been treated with zidovudine for 24 months shows an accumulation of fine reddish granules in the sarcoplasm, corresponding to mitochondria in atrophic fibers (trichrome, x600). In addition to mitochondrial accumulation, the fibers show marked myofilamentous abnormalities that include myofibrillar loss and cytoplasmic-body formation (arrows).

 


Patrick Chariot, M.D.
Hopital Henri-Mondor
94000 Creteil, France


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