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Correspondence
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Volume 328:1710-1712 June 10, 1993 Number 23
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Prenatal Diagnosis

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 by D'Alton, M. E.
To the Editor: In their discussion of prenatal diagnosis and the role of the "triple test" in screening for Down's syndrome, D'Alton and DeCherney (Jan. 14 issue)1 stated that the triple test "can identify approximately 60 percent of cases of Down's syndrome, with a false positive rate of 6.6 percent," a rate that is reduced to 3.8 percent if ultrasonography is used to confirm gestational age. However, they failed to comment that lower detection rates (48 percent, with a false positive rate of 5.7 percent -- 4.1 percent after ultrasonography) have been shown in other prospective studies of triple screening,2 . . . [Full Text of this Article]

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