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Correspondence
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Volume 328:1713-1714 June 10, 1993 Number 23
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Chronic Idiopathic Diarrhea

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To the Editor: As Afzalpurkar et al. (Dec. 24 issue)1 note, many features of the chronic idiopathic diarrhea they describe also occur in Brainerd diarrhea, a chronic diarrheal syndrome described after outbreaks in Minnesota and Illinois2,3. The authors suggest that the absence of four features -- an identified point source, inflammation of colonic-biopsy specimens, fecal leukocytes, and intractable disease -- distinguish their patients from patients with Brainerd diarrhea. We believe, however, that their criteria are unreliable.

Point sources of Brainerd diarrhea are rarely identified, though cases of sporadic illness indistinguishable from Brainerd diarrhea have been reported in many states2,4. . . [Full Text of this Article]

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