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Previous Volume 328:1817-1819 June 24, 1993 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The spectrum of hematologic and immunologic abnormalities in human immunodeficiency virus type 1 (HIV-1) infection is broad^1,2. Although the incidence of B-cell-associated neoplasms is increased, relatively few cases of multiple myeloma have been described^3,4. There are, however, reports of patients in whom serum paraproteins present as single or oligoclonal bands^{5,6,7,8,9,10,11}. These paraproteins have previously been thought of as part of the exuberant polyclonal response to HIV-1^10,11.

In this report, we describe an HIV-1-positive patient with myeloma whose IgG- paraprotein specifically recognized the HIV-1 p24 gag antigen. It is possible that an HIV-1 antigen-driven response played an . . . [Full Text of this Article]

Case Report

Results

Discussion

Source Information

From the Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 6 Founders Bldg., 3400 Spruce St., Philadelphia, PA 19104-6082, where reprint requests should be addressed to Dr. Silberstein.

References

This article has been cited by other articles:

• Park, D.-S., Cho, J.-H., Lee, J.-H., Lee, K.-E. (2009). Clinical Course of Monoclonal and Oligoclonal Gammopathies in Patients Infected with Orientia tsutsugamushi. Am J Trop Med Hyg 81: 660-664 [Abstract] [Full Text]  
• Seeborg, F. O., Gay, H., Schmiege, L. M. III, Bernard, D., Shearer, W. T. (2005). Immunoglobulin G({kappa}) [IgG({kappa})] and IgG({lambda}) Paraproteinemia in a Child with AIDS and Response to Highly Active Antiretroviral Therapy. CVI 12: 1331-1333 [Abstract] [Full Text]  
• Cheung, M. C., Pantanowitz, L., Dezube, B. J. (2005). AIDS-Related Malignancies: Emerging Challenges in the Era of Highly Active Antiretroviral Therapy. The Oncologist 10: 412-426 [Abstract] [Full Text]  
• Miranda, E. G., Iravani, S., Doll, D. C. (2001). Unusual Presentations of Malignancy: Case 2. Breast Plasmacytoma in a Patient with Human Immunodeficiency Virus. JCO 19: 3290-3291 [Full Text]  
• Attaelmannan, M., Levinson, S. S. (2000). Understanding and Identifying Monoclonal Gammopathies. Clin. Chem. 46: 1230-1238 [Abstract] [Full Text]  
• Kaplon, M. K., Karnad, A. B. (1997). Multiple Myeloma in Young Patients. Arch Intern Med 157: 361-361 [Abstract]