Hepatic fibrosis is a common response to chronic liver injuryfrom many causes, including alcohol, persistent viral and helminthicinfections, and hereditary metal overload. Emerging evidencesuggests that cellular mechanisms of hepatic fibrosis are sharedamong these different insults and, moreover, that the liver'sresponse is a paradigm for parenchymal wound healing in othertissues.
Advances in the isolation and characterization of liver cells,in conjunction with progress in matrix and cytokine biology,have led to important new insights about the cellular basisof hepatic fibrosis. In particular, the hepatic lipocyte (alsoknown as the stellate, fat-storing, perisinusoidal, or Ito . . . [Full Text of this Article]
The Nature of the Hepatic Scar
Cellular Sources of Extracellular Matrix in Hepatic Fibrosis: The Role of the Activated Lipocyte
Lipocytes: The Main Source of Extracellular Matrix in Liver Injury
Lipocyte Activation: The Critical Event in Early Hepatic Fibrosis
Initiation of Lipocyte Activation
Perpetuation of Lipocyte Activation
Therapies for Hepatic Fibrosis
Current Therapies
Future Therapies
Conclusions
Discussion
Source Information
From the Department of Medicine, University of California, San Francisco, and the Medical Service, San Francisco General Hospital, San Francisco.
Address reprint requests to Dr. Friedman at UCSF Liver Center Laboratory, San Francisco General Hospital, Bldg. 40, Rm. 4102, San Francisco, CA 94110.
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