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Previous Volume 328:1851-1852 June 24, 1993 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Schroeder et al. (Jan. 21 issue)¹ present preliminary evidence to suggest that the calcium-channel blocker diltiazem prevents the accelerated coronary artery disease observed in heart-transplant recipients. They attempt to explain their findings by citing previously published work on the antiatherogenic properties of calcium-channel blockers. However, coronary artery narrowing after heart transplantation is likely to be multifactorial in its genesis, with immune-mediated endothelial injury playing a prominent part². In addition, calcium-channel blockers may possess immunosuppressive activity, and diltiazem, nifedipine, and verapamil have been shown to reduce the number of rejection episodes and improve graft outcome in renal-transplant . . . [Full Text of this Article]

References

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• Suzuki, J.-i., Isobe, M., Morishita, R., Nishikawa, T., Amano, J., Kaneda, Y. (2000). Antisense Bcl-x oligonucleotide induces apoptosis and prevents arterial neointimal formation in murine cardiac allografts. Cardiovasc Res 45: 783-787 [Abstract] [Full Text]