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Previous Volume 328:284-285 January 28, 1993 Number 4 Next

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To the Editor: The study by Rowland et al. (Oct. 1 issue)¹ clearly demonstrated reduced fertility among female dental assistants exposed to high levels of unscavenged nitrous oxide. The authors also reported, but did not comment on, a higher rate of spontaneous abortion (50 percent) in 10 pregnant women exposed to high levels of unscavenged nitrous oxide, as compared with an 8 percent rate of fetal loss in 315 pregnant women with no exposure to nitrous oxide or exposure to a lower level. This difference is significant (P = 0.001 by Fisher's exact test) and suggests that nitrous oxide may . . . [Full Text of this Article]

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