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Correspondence
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Volume 328:357-358 February 4, 1993 Number 5
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Electrophysiologically Guided Antiarrhythmic Therapy versus Beta-Blocker Therapy in Patients with Ventricular Tachyarrhythmias

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To the Editor: In their study comparing the outcomes of electrophysiologically guided antiarrhythmic therapy with those of empirical beta-blocker therapy in patients presenting with sustained ventricular arrhythmias, Steinbeck et al. (Oct. 1 issue)1 fail to take into account two important confounding variables. First, their study enrolled patients with coronary artery disease, cardiomyopathy, and other structural heart disease, without attempting to discern differences in outcome among these various groups. It has been repeatedly demonstrated that patients with cardiomyopathy and ventricular arrhythmias differ markedly from patients with coronary artery disease in their underlying substrate,2 response to serial electrophysiologic testing,3 and outcome3. . . . [Full Text of this Article]

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