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A correction has been published: N Engl J Med 1993;328(24):1796.

Case Records of the Massachusetts General Hospital
Weekly Clinicopathological Exercises
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Volume 328:496-502 February 18, 1993 Number 7
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Case 7-1993— A Six-Year-Old Boy with Multiple Bone Lesions, Repeated Fractures, and Sexual Precocity
Joseph A. Majzoub, and Robert E. Scully

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Presentation of Case

A boy six years and two months old was admitted to the hospital because of sexual precocity, polyostotic fibrous dysplasia, and cafe-au-lait spots.

The boy was born after a 37-week, uncomplicated pregnancy to a 23-year-old primigravida; he was delivered by cesarean section because of failure to progress and a decrease in the heart rate noted on the fetal monitor; the birth weight was 2.66 kg. The infant was discharged home at four days with his mother. He reached his milestones at appropriate ages; he walked at 11 months and was toilet-trained at 2 1/2 years. At the ages of three, . . . [Full Text of this Article]

Differential Diagnosis

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Dr. Joseph A. Majzoub's Diagnosis

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