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Previous Volume 328:665-666 March 4, 1993 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The reports by Cheung et al.¹ and O'Connor et al.². (Oct. 22 issue) that the repeated administration of (±)-salmeterol¹ or (±)-terbutaline² results in diminished protection against bronchoconstrictor stimuli, despite sustained bronchodilator activity, are consistent with an earlier description of this phenomenon in patients exposed to (±)-albuterol³. In each instance this paradox has been interpreted as a manifestation of tolerance (i.e., adrenoceptor tachyphylaxis), disregarding the possibility that acute suppression of airway hyperreactivity by adrenoceptor activation⁴ may be nullified by the progressive induction of hyperreactivity during sustained exposure to these racemic mixtures⁵.

It has long been . . . [Full Text of this Article]

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