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Original Article
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Volume 329:27-29 July 1, 1993 Number 1
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Lymphoma of Donor Origin Occurring in the Porta Hepatis of a Transplanted Liver
Ira J. Spiro, David W. Yandell, Chuan Li, Sanjay Saini, Judith Ferry, John Powelson, William N. Katkov, and A. Benedict Cosimi

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Non-Hodgkin's lymphoma after organ transplantation is a recognized complication of immunosuppressive therapy. A number of cases of post-transplantation lymphoma arising in allografted tissue have been described1. In addition, leukemia and lymphoma arising from donor cells after allogeneic bone marrow transplantation have been recognized2,3,4,5,6,7,8. Two cases of donor-related lymphoma in renal allografts have also been reported9,10.

We describe the development of a lymphoma in a hepatic allograft recipient 4.5 months after orthotopic liver transplantation. Using a rapid technique based on the polymerase chain reaction (PCR), which makes use of a DNA sequence polymorphism at the D4S174 locus on . . . [Full Text of this Article]

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From the Departments of Radiation Oncology (I.J.S.), Surgery (J.P., A.B.C.), Radiology (S.S.), Pathology (J.F.), and Medicine (W.N.K.), Massachusetts General Hospital; Harvard University School of Public Health (C.L., D.W.Y.); and Massachusetts Eye and Ear Infirmary (D.W.Y.) -- all in Boston.

Address reprint requests to Dr. Spiro at the Department of Radiation Oncology, Massachusetts General Hospital, Fruit St., Boston, MA 02114.

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