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Previous Volume 329:51-53 July 1, 1993 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although two centuries of anecdotal clinical evidence support the use of cardiac glycosides for the treatment of heart failure, controversy has surrounded their efficacy and appropriate indications. Early in this century, two of the founders of the clinical discipline of cardiology, Sir James Mackenzie in London and Henry Christian in Boston, had sharply differing views that have tended to persist in the United Kingdom and the United States, respectively. Mackenzie advocated the use of digitalis only in patients with supraventricular tachyarrhythmias, such as atrial fibrillation, whereas Christian believed that "digitalis . . . has a striking effect on those changes . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Adams, K. F. Jr, Patterson, J. H., Gattis, W. A., O'Connor, C. M., Lee, C. R., Schwartz, T. A., Gheorghiade, M. (2005). Relationship of Serum Digoxin Concentration to Mortality and Morbidity in Women in the Digitalis Investigation Group Trial: A Retrospective Analysis. J Am Coll Cardiol 46: 497-504 [Abstract] [Full Text]  
• Maixent, J.-M., Gerbi, A., Barbey, O., Lan, C., Jamme, I., Burnet, H., Nouvelot, A., Levy, S., Cozzone, P. J., Bernard, M. (1999). Dietary fish oil promotes positive inotropy of ouabain in the rat heart. Am. J. Physiol. Heart Circ. Physiol. 277: H2290-H2297 [Abstract] [Full Text]  
• van Veldhuisen, D.J., Charlesworth, A., Crijns, H.J.G.M., Lie, K.I., Hampton, J.R. (1999). Differences in drug treatment of chronic heart failure between European countries. Eur Heart J 20: 666-672 [Abstract]  
• Dargie, H J, McMurray, J J V (1994). Fortnightly Review: Diagnosis and management of heart failure. BMJ 308: 321-328 [Abstract] [Full Text]  
• Swedberg, K., Wedel, H., Neely, D., Schwartz, A., Feldman, A. M., Bristow, M. R., Parmley, W. W., Packer, M. (1994). Vesnarinone for Heart Failure. NEJM 330: 64-66 [Full Text]  
• (1993). ACE INHIBITORS DON'T ELIMINATE THE NEED FOR DIGOXIN. JWatch General 1993: 1-1 [Full Text]