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Correspondence
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Volume 329:60-62 July 1, 1993 Number 1
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Early Detection of HIV in Neonates

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 by Miles, S. A.
To the Editor: Miles et al. (Feb. 4 issue)1 suggest that the immune-complex-dissociated HIV p24 antigen assay may be of value in the early diagnosis of pediatric human immunodeficiency virus (HIV) infection. We do not believe that the data they present adequately support this conclusion. The relative benefit of dissociation cannot be established, since the results of HIV p24 antigen detection in the untreated samples were not reported. A blocking assay was not performed to confirm the positive results that were observed not only in infected infants but also in 2 of 22 uninfected infants. The number of children studied . . . [Full Text of this Article]

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